PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOMER2	0	RYR1	18	pull down, affinity chromatography technology	Feng W (2002), Feng W (2002)	2
HOMER3	0	HOMER2	0	affinity chromatography technology	Huttlin EL (2017)	1
CALM1	0	TRDN	0	pull down	Shen X (2005)	1
RYR1	18	CALM1	0	far western blotting, fluorescent resonance energy transfe	Yamaguchi N (2001), Boschek CB (2008)	2
HOMER3	0	HOMER1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
HOMER1	1	RYR1	18	pull down, pull down, affinity chromatography technology	Hwang SY (2003), Feng W (2002), Feng W (2002)	3
RYR1	18	ANK1	8	pull down	Bourguignon LY (1995)	1
RYR1	18	TRDN	0	pull down, pull down, pull down, unspecified method, far western blotting	Lee JM (2004), Caswell AH (1999), Guo W (1995), Groh S (1999), Groh S (1999)	5
RYR1	18	FKBP1A	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Avila G (2003), Bultynck G (2001), Bultynck G (2001), Gaburjakova M (2001)	4
S100A1	1	RYR1	18	pull down	Treves S (1997)	1
HOMER3	0	RYR1	18	affinity chromatography technology, pull down	Feng W (2002), Feng W (2002)	2
CALM1	0	RYR2	26	pull down, affinity chromatography technology	Nyegaard M (2012), Vassilakopoulou V (2015)	2
HOMER1	1	HOMER2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RYR1	18	RYR2	26	affinity chromatography technology	Xiao B (2002)	1
HOMER1	1	RYR2	26	pull down	Westhoff JH (2003)	1