PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TGFBR2	0	ACVR1	4	two hybrid	Kawabata M (1995)	1
PDCD1	4	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
TPCN2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
USP15	4	BMPR1B	3	affinity chromatography technology	Herhaus L (2014)	1
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
BMPR1A	5	FKBP1A	0	two hybrid	Kurozumi K (1998)	1
USP15	4	BMPR1A	5	affinity chromatography technology, imaging technique, enzymatic study	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
ARRDC3	0	NEDD4L	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
LITAF	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
ACVR1	4	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
BMPR1B	3	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
BMPR1A	5	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
GDF5	0	BMPR2	1	pull down	Erlacher L (1998)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
BMPR1A	5	FKBP1B	0	two hybrid	Nishanian TG (2004)	1
CD83	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	BMP6	2	affinity chromatography technology	Ebisawa T (1999)	1
PEG10	2	BMPR1B	3	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
FAM171B	3	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1B	3	OTUB1	0	enzymatic study	Herhaus L (2015)	1
MRAP2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	BMP2	2	x-ray crystallography, pull down, pull down, pull down	Nickel J (2001), Kirsch T (2000), Kirsch T (2000), Gilboa L (2000)	4
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
C16orf58	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	TSPAN17	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SLC20A1	2	affinity chromatography technology	Choudhury NR (2017)	1
BMPR1B	3	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Itoh F (2001), Hata A (1998)	2
FKBP1A	0	ACVR1	4	affinity chromatography technology	Chaikuad A (2012)	1
TRIM25	5	TNFRSF10A	0	affinity chromatography technology	Choudhury NR (2017)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
BMPR1A	5	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	LITAF	0	affinity chromatography technology	Choudhury NR (2017)	1
MRAP2	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1B	3	SMURF1	4	affinity chromatography technology	Murakami G (2003)	1
ACVR1	4	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Pardali E (2000), Macias-Silva M (1998)	2
ADGRG5	1	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	BMP6	2	affinity chromatography technology	Choudhury NR (2017)	1
IL17RB	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
MAS1	2	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	BMPR1A	5	affinity chromatography technology	Choudhury NR (2017)	1
PDGFRB	8	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	SF3B4	2	two hybrid, affinity chromatography technology	Nishanian TG (2004), Nishanian TG (2004)	2
SMAD7	1	TGFBR2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavsak P (2000), Nakao A (1997), Hsu HY (2014)	3
TRIM25	5	TGFBR2	0	affinity chromatography technology	Choudhury NR (2017)	1
BMPR2	1	BMP4	0	affinity chromatography technology, pull down	Rosenzweig BL (1995), Rudarakanchana N (2002)	2
IFNGR1	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
RGMB	1	BMP4	0	pull down	Samad TA (2005)	1
TSC22D1	1	OTUB1	0	two hybrid	Vinayagam A (2011)	1
MANSC1	4	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	BMPR1A	5	pull down	Persaud A (2009)	1
LITAF	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Li W (2015), Huttlin EL (2017)	2
RGMB	1	BMP2	2	pull down	Samad TA (2005)	1
BMPR1A	5	CAV1	0	affinity chromatography technology	Nohe A (2005)	1
NEDD4L	3	BMPR1A	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
BMPR2	1	BMPR1B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
SMAD6	9	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BMPR1B	3	affinity chromatography technology, imaging technique	Gilboa L (2000), Gilboa L (2000)	2
LITAF	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shirk AJ (2005), Li W (2015), Huttlin EL (2017)	3
TGFBR2	0	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP15	4	ACVR1	4	affinity chromatography technology	Herhaus L (2014)	1
GINM1	1	BMPR1A	5	affinity chromatography technology	Huttlin EL (2015)	1
TMEM52B	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	BMPR1A	5	genetic interference	Toyoshima M (2012)	1
C16orf58	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
HAVCR2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	BMPR1A	5	affinity chromatography technology, fluorescent resonance energy transfe	Gilboa L (2000), Lavery K (2008)	2
ACVR1	4	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
SMAD7	1	TSC22D1	1	affinity chromatography technology, affinity chromatography technology	Yan X (2011), Yan X (2011)	2
PEG10	2	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
HSP90AA1	7	BMPR1A	5	affinity chromatography technology	Taipale M (2012)	1
IL4R	1	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
FST	0	BMPR1A	5	x-ray crystallography	Thompson TB (2005)	1
BMP7	3	SMAD1	0	genetic interference	Guo X (2001)	1
SNX11	3	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GDF6	1	BMPR2	1	pull down	Erlacher L (1998)	1
NEDD4	2	PDGFRB	8	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
BMP7	3	BMPR2	1	affinity chromatography technology, affinity chromatography technology	Liu F (1995), Rosenzweig BL (1995)	2
BMP7	3	BMPR1A	5	pull down	ten Dijke P (1994)	1
C16orf58	0	IFNGR1	0	affinity chromatography technology	Huttlin EL (2017)	1
CLDND1	3	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACVR1	4	BMPR1A	5	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Lavery K (2008), Lavery K (2008), Huttlin EL (2015), Huttlin EL (2017)	4
SMAD6	9	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
PTGER3	2	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
CAV1	0	PDGFRB	8	affinity chromatography technology, biochemical, pull down	Yamamoto M (1999), Yamamoto M (1999), Yamamoto M (1999)	3
SMAD6	9	BMPR1A	5	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1B	3	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
IL4R	1	NEDD4L	3	affinity chromatography technology	Warren KJ (2016)	1
TNFRSF10A	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
CD83	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
TGFBR2	0	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
SMAD7	1	NEDD4L	3	affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Al-Salihi MA (2012), Aragon E (2012), Aragon E (2012), Aragon E (2012)	4
GDF6	1	BMPR1A	5	pull down	Erlacher L (1998)	1
BMP4	0	BMPR1B	3	pull down	ten Dijke P (1994)	1
RUNX2	2	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang YW (2000), Zhang YW (2000), Hanai J (1999), Jun JH (2010), Wang Q (2007)	5
C14orf37	0	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1
LRRIQ1	5	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR1A	5	IGSF1	3	affinity chromatography technology	Chapman SC (2001)	1
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
ADGRG5	1	IFNGR1	0	affinity chromatography technology	Huttlin EL (2017)	1
TSPAN17	1	BMPR1A	5	affinity chromatography technology	Huttlin EL (2015)	1
HEPACAM2	3	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
SMAD1	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Inui M (2011), Eichhorn PJ (2012)	2
ACVR1	4	TSC22D1	1	affinity chromatography technology	Yan X (2011)	1
TRIM25	5	SF3B4	2	affinity chromatography technology	Choudhury NR (2017)	1
TMEM52B	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM52B	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC3	0	NEDD4	2	affinity chromatography technology, imaging technique, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Nabhan JF (2010), Qi S (2014), Qi S (2014), Qi S (2014), Huttlin EL (2017)	6
SMAD6	9	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Herhaus L (2014), Herhaus L (2014), Herhaus L (2014)	3
BMPR2	1	ACVR1	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Liu F (1995), Liu F (1995), Liu F (1995), Liu F (1995), Kawabata M (1995), Huttlin EL (2017)	6
SMAD7	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Kamiya Y (2010)	2
SMURF1	4	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Ebisawa T (2001), Johansson E (2016)	2
RUNX2	2	BMPR1A	5	affinity chromatography technology	Jeon EJ (2006)	1
BMP7	3	BMPR1B	3	pull down	ten Dijke P (1994)	1
BMPR1A	5	OTUB1	0	enzymatic study	Herhaus L (2015)	1
SMAD6	9	NEDD4	2	affinity chromatography technology	Kuratomi G (2005)	1
RGMB	1	ACVR1	4	affinity chromatography technology	Samad TA (2005)	1
ACVR1	4	GDF5	0	affinity chromatography technology	Nishitoh H (1996)	1
RUNX2	2	SMURF1	4	imaging technique	Wang Q (2007)	1
C14orf37	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
BMP2	2	BMPR2	1	affinity chromatography technology, pull down, pull down	Liu F (1995), Kirsch T (2000), Gilboa L (2000)	3
MRAP2	0	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
BMPR2	1	BMPR1A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Liu F (1995), Liu F (1995), Gilboa L (2000), Gilboa L (2000)	4
LRRIQ1	5	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	C14orf37	0	affinity chromatography technology	Choudhury NR (2017)	1
GDF5	0	BMPR1A	5	pull down	Erlacher L (1998)	1
SMAD7	1	BMPR2	1	affinity chromatography technology	Kamiya Y (2010)	1
FKBP1A	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Yamaguchi T (2006), Yamaguchi T (2006)	2
ACVR1	4	OTUB1	0	enzymatic study	Herhaus L (2015)	1
SMAD6	9	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Kamiya Y (2010), Zhang X (2013)	2
RGMB	1	BMPR1B	3	affinity chromatography technology	Samad TA (2005)	1
TRIM25	5	TPCN2	0	affinity chromatography technology	Choudhury NR (2017)	1
SMAD7	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuratomi G (2005), Kuratomi G (2005), Al-Salihi MA (2012)	3
RGMB	1	BMPR1A	5	affinity chromatography technology	Samad TA (2005)	1
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
BMP7	3	ACVR1	4	pull down	ten Dijke P (1994)	1
FKBP1A	0	SF3B4	2	two hybrid	Rolland T (2014)	1
SMAD1	0	NEDD4	2	affinity chromatography technology, two hybrid	Kim BG (2011), Colland F (2004)	2
BMPR1A	5	SMAD1	0	enzymatic study	Kretzschmar M (1997)	1
BMPR1A	5	ZMYND11	10	two hybrid, affinity chromatography technology	Kurozumi K (1998), Kurozumi K (1998)	2
SMAD6	9	NEDD4L	3	affinity chromatography technology	Herhaus L (2014)	1
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
TLR2	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
ACVR1	4	BAMBI	3	pull down	Yan X (2009)	1
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
SMAD7	1	BAMBI	3	affinity chromatography technology, affinity chromatography technology	Yan X (2009), Yan X (2009)	2
BMPR1B	3	BAMBI	3	pull down	Yan X (2009)	1
SMAD6	9	BAMBI	3	affinity chromatography technology	Yan X (2009)	1
FSHR	2	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
SMAD7	1	ACVR1	4	affinity chromatography technology	Kamiya Y (2010)	1
BMPR1A	5	BAMBI	3	pull down	Yan X (2009)	1
HAVCR2	0	CLDND1	3	affinity chromatography technology	Huttlin EL (2017)	1
BMP4	0	BMPR1A	5	pull down	ten Dijke P (1994)	1
BMP2	2	BMPR1B	3	pull down	Gilboa L (2000)	1
SLC20A1	2	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
ARRDC3	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
GDF6	1	BMPR1B	3	pull down	Erlacher L (1998)	1
HSP90AA1	7	PDGFRB	8	affinity chromatography technology	Taipale M (2012)	1
BMPR2	1	CAV1	0	affinity chromatography technology	Nohe A (2005)	1
GDF5	0	BMPR1B	3	pull down	Erlacher L (1998)	1
FST	0	BMPR2	1	x-ray crystallography	Thompson TB (2005)	1
IL1R1	0	BMPR1A	5	affinity chromatography technology	Huttlin EL (2017)	1
BMPR2	1	BMP6	2	affinity chromatography technology	Ebisawa T (1999)	1
TNFRSF10A	0	ACVR1	4	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF10A	0	IL4R	1	affinity chromatography technology	Huttlin EL (2017)	1
PEG10	2	ACVR1	4	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
HSP90AA1	7	TGFBR2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012)	5
SMAD7	1	MYC	2	affinity chromatography technology, affinity chromatography technology	Kim TA (2013), Kim TA (2013)	2
PEG10	2	TGFBR2	0	affinity chromatography technology, affinity chromatography technology	Lux A (2005), Lux A (2005)	2
LRRIQ1	5	BMPR2	1	affinity chromatography technology	Huttlin EL (2017)	1