PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM21	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
CASP8AP2	3	FADD	1	affinity chromatography technology	Imai Y (1999)	1
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
UBE2H	3	TRIM5	4	two hybrid	Markson G (2009)	1
UBC	7	AGO3	4	affinity chromatography technology	Matsumoto M (2005)	1
TRIM21	0	TRIM5	4	pull down	Li X (2006)	1
CFTR	5	SKP1	0	affinity chromatography technology	Pankow S (2015)	1
DPPA4	0	TRIM21	0	affinity chromatography technology	Oliviero G (2015)	1
USP19	1	TRIM21	0	affinity chromatography technology	Sowa ME (2009)	1
AGO3	4	TRIM21	0	affinity chromatography technology	Weinmann L (2009)	1
HLA-DRB1	1	VCP	6	affinity chromatography technology	Takahata M (2008)	1
IRF3	4	IRF7	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Au WC (2001), Au WC (2001), Higgs R (2008), Higgs R (2008)	4
NOS2	6	YWHAZ	1	affinity chromatography technology	Foster MW (2013)	1
USP2	0	MNAT1	0	two hybrid	Hayes SD (2012)	1
TRIM27	2	DAXX	5	affinity chromatography technology	Chen A (2006)	1
TRIM21	0	USP4	3	two hybrid, enzymatic study, enzymatic study, two hybrid	Di Donato F (2001), Wada K (2006), Wada K (2006), Hayes SD (2012)	4
AGO4	5	TRIM21	0	affinity chromatography technology	Weinmann L (2009)	1
CFTR	5	USP19	1	affinity chromatography technology	Hassink GC (2009)	1
CYLD	2	PRMT5	3	affinity chromatography technology	Elliott PR (2016)	1
SQSTM1	0	PAWR	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chang S (2002), Chang S (2002), Chang S (2002), Chang S (2002)	4
UBE2D1	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Kreft SG (2003)	2
HDAC1	4	USP19	1	affinity chromatography technology, affinity chromatography technology	Wu M (2017), Wu M (2017)	2
FBXO6	0	GMPS	1	affinity chromatography technology	Liu B (2012)	1
MYC	2	CUL1	7	affinity chromatography technology	von der Lehr N (2003)	1
CDK2	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Youn CK (2005), Porter LA (2003), Law BK (2002), Connor MK (2003), Naderi S (2005), Varshochi R (2005), Hsu SP (2008), McAndrew CW (2007), Peiretti A (2003), Peiretti A (2003), Haddad MM (1999), Xu X (1999), Xu X (1999), Radu M (2008), Mori S (1999), Schulman BA (1998), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Sheaff RJ (1997), Vlach J (1996), Vlach J (1996), Vlach J (1997), Liu S (2009), Rosner M (2004), Ciarallo S (2002), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Chu I (2007), Chu I (2007), Levkau B (1998), Levkau B (1998), Lacy ER (2005), Zhao J (1998), Seo DW (2006), Kossatz U (2006), Grimmler M (2007), Grimmler M (2007), Varjosalo M (2013), Varjosalo M (2013), Montagnoli A (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Lovisa S (2016), Qiu H (2016), Carrasco-Garcia E (2011), Huttlin EL (2017), Hu B (2017)	52
USP4	3	USP19	1	affinity chromatography technology	Zhang L (2012)	1
PAN2	3	SQSTM1	0	affinity chromatography technology	Bett JS (2013)	1
NPM1	0	SQSTM1	0	affinity chromatography technology	Chen R (2013)	1
USP2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
VCP	6	YWHAG	5	affinity chromatography technology	Yu CC (2013)	1
CRBN	2	TRIM21	0	affinity chromatography technology	Nguyen TV (2016)	1
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
CFTR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye S (2010), Ye S (2010), Bomberger JM (2012), Arora K (2016)	4
APC	5	TRIM21	0	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Novellasdemunt L (2017)	2
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
AGO3	4	PRMT5	3	affinity chromatography technology	Weinmann L (2009)	1
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
ZNF598	6	TRIM21	0	affinity chromatography technology	Garzia A (2017)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
CYLD	2	USP15	4	affinity chromatography technology	Elliott PR (2016)	1
MNAT1	0	TRIM21	0	two hybrid	Woodsmith J (2012)	1
UBE2L3	1	TRIM39	0	two hybrid	Markson G (2009)	1
CDK2	0	YWHAZ	1	affinity chromatography technology	Neganova I (2011)	1
MAP1LC3C	0	UBC	7	imaging technique	Liu X (2017)	1
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
HDAC1	4	MAP1LC3B	1	genetic interference	Xie HJ (2012)	1
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
ROR1	2	TRIM21	0	affinity chromatography technology	Bicocca VT (2012)	1
BAG6	2	TRIM21	0	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
IRF3	4	IRF5	0	pull down	Barnes BJ (2001)	1
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
VCP	6	CDKN1B	1	affinity chromatography technology	Yu CC (2013)	1
GABARAPL1	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
IKBKB	1	CUL1	7	affinity chromatography technology	Orel L (2010)	1
CFTR	5	YWHAG	5	affinity chromatography technology	Pankow S (2015)	1
HDAC1	4	CASP8AP2	3	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	CDC34	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu K (2010), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014)	5
UBE2L3	1	RBCK1	0	two hybrid, pull down, pull down	Markson G (2009), Tatematsu K (2008), Kirisako T (2006)	3
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
SKP2	2	USP19	1	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
G3BP1	4	PRMT5	3	affinity chromatography technology	Jain S (2016)	1
TRIM21	0	28396	0	two hybrid	Rolland T (2014)	1
ULK1	8	G3BP1	4	affinity chromatography technology	Behrends C (2010)	1
USP2	0	TRIM27	2	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
SKP2	2	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang W (2003), Sitry D (2002), Fujita N (2002), Ji P (2006), Zancai P (2005), Ji P (2004), Iovine B (2011), Calvisi DF (2009), Spruck C (2001), Bashir T (2010), Bashir T (2010), Li P (2004), Boutonnet C (2010), Rosner M (2004), Rosner M (2004), Carrano AC (1999), Carrano AC (1999), Carrano AC (1999), Wu J (2012), Strohmaier H (2001), Rodier G (2008), Rodier G (2008), Ooi LC (2013), Yumimoto K (2013), Ooi LC (2013), Cen B (2010), Enchev RI (2012), Yumimoto K (2012), Shi P (2011), Lovisa S (2016), Cen B (2009), Chan CH (2013), Ma X (2017)	33
GABARAPL1	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
DPPA4	0	CRBN	2	affinity chromatography technology	Oliviero G (2015)	1
UBE2H	3	TRIM27	2	two hybrid	Markson G (2009)	1
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
TRIM21	0	UBE2H	3	pull down	Wada K (2006)	1
GAN	4	PRMT5	3	affinity chromatography technology	Johnson-Kerner BL (2015)	1
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
UBE2I	0	CDKN1B	1	enzymatic study	Lovisa S (2016)	1
CFTR	5	CALR	1	affinity chromatography technology	Pankow S (2015)	1
YWHAZ	1	CDKN1B	1	pull down	Sekimoto T (2004)	1
ULK1	8	BECN1	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bodemann BO (2011), Chauhan S (2015), Chauhan S (2016)	3
TRIM21	0	GRAP	0	two hybrid	Rolland T (2014)	1
NCOA3	3	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Wu RC (2002), Jung SY (2005)	2
TRIM5	4	SQSTM1	0	affinity chromatography technology	OConnor C (2010)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
NANOG	0	TRIM21	0	affinity chromatography technology	Oliviero G (2015)	1
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
TRIM21	0	CALR	1	pull down, two hybrid	Cheng ST (1996), Cheng ST (1996)	2
FBXO6	0	TRIM21	0	affinity chromatography technology	Liu B (2012)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
CDC5L	2	YWHAZ	1	two hybrid	Camargo LM (2007)	1
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
TRIM21	0	HLA-DRB1	1	two hybrid, affinity chromatography technology	Takahata M (2008), Takahata M (2008)	2
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
UBE2D1	0	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
HIST1H3E	0	TRIM21	0	affinity chromatography technology	Campos EI (2015)	1
TRIM21	0	NIF3L1	0	two hybrid	Rual JF (2005)	1
IRF3	4	USP19	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	YWHAG	5	affinity chromatography technology	Neganova I (2011)	1
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
TRIM21	0	IRF5	0	affinity chromatography technology, pull down	Lazzari E (2014), Lazzari E (2014)	2
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
HIST1H3E	0	PRMT5	3	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
UBE2I	0	NMI	3	two hybrid	Yu H (2011)	1
CDK2	0	TRIM21	0	affinity chromatography technology	Neganova I (2011)	1
TRIM21	0	RBCK1	0	two hybrid	Woodsmith J (2012)	1
YWHAZ	1	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FCGR2A	0	CBL	7	biochemical	Marois L (2009)	1
CDK2	0	UBE2H	3	enzymatic study	Lv Z (2017)	1
NF2	1	HDAC1	4	affinity chromatography technology	Zhou L (2015)	1
CBL	7	TRIM8	6	two hybrid	Woodsmith J (2012)	1
AGO4	5	AGO3	4	affinity chromatography technology, affinity chromatography technology	Weinmann L (2009), Li S (2014)	2
IRF3	4	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang K (2009), Yang K (2009), Yang K (2009), Yang K (2009), Stacey KB (2012), Higgs R (2008), Higgs R (2008)	7
GABARAP	0	TRIM21	0	pull down	Kimura T (2015)	1
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
PAN2	3	PAWR	2	affinity chromatography technology	Bett JS (2013)	1
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
CYLD	2	NF2	1	affinity chromatography technology	Elliott PR (2016)	1
UBE2I	0	RNF111	2	two hybrid, two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010), Rolland T (2014)	3
CYLD	2	PFKFB2	4	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	G3BP1	4	affinity chromatography technology	Elliott PR (2016)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
TRIM21	0	DAXX	5	affinity chromatography technology, two hybrid	Tanaka M (2010), Tanaka M (2010)	2
IRF8	4	CBL	7	affinity chromatography technology	Xiong H (2005)	1
IFI35	1	NMI	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen J (2000), Chen J (2000), Huttlin EL (2015), Das A (2015), Das A (2015), Huttlin EL (2017)	6
HDAC1	4	DZIP3	6	affinity chromatography technology	Zhou W (2008)	1
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
ULK1	8	GABARAPL2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method	Okazaki N (2000), Okazaki N (2000), Behrends C (2010), Alemu EA (2012), Alemu EA (2012)	5
USP2	0	TRIM5	4	two hybrid	Hayes SD (2012)	1
MYC	2	NMI	3	affinity chromatography technology, pull down, two hybrid	Li H (2002), Li H (2002), Bannasch D (1999)	3
TRIM21	0	CDKN1B	1	affinity chromatography technology	Sabile A (2006)	1
PFKFB2	4	TRIM21	0	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	TRIM21	0	affinity chromatography technology	Lleres D (2010)	1
MAP1LC3B	1	GABARAPL2	0	pull down	Maruyama Y (2014)	1
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
HDAC1	4	TRIM21	0	affinity chromatography technology	Terhune SS (2010)	1
TRIM21	0	FCGR2A	0	affinity chromatography technology, affinity chromatography technology	Rhodes DA (2007), Rhodes DA (2007)	2
CRBN	2	VCP	6	affinity chromatography technology	Nguyen TV (2016)	1
G3BP1	4	CDC5L	2	affinity chromatography technology	Jain S (2016)	1
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
IQCB1	3	3500	0	affinity chromatography technology	Sang L (2011)	1
NF2	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IRF7	2	TRIM21	0	affinity chromatography technology	Higgs R (2010)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
FBXW11	2	TRIM21	0	pull down, affinity chromatography technology	Sabile A (2006), Sabile A (2006)	2
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
ZNF598	6	VCP	6	affinity chromatography technology	Garzia A (2017)	1
TROVE2	4	TRIM21	0	biochemical	Fabini G (2000)	1
YWHAG	5	CDC5L	2	affinity chromatography technology	Jin J (2004)	1
UBC	7	G3BP1	4	affinity chromatography technology	Matsumoto M (2005)	1
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
TRIM21	0	UBE2I	0	two hybrid	Rolland T (2014)	1
G3BP1	4	TRIM21	0	affinity chromatography technology	Jain S (2016)	1
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM21	0	CDC34	3	pull down	Wada K (2006)	1
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
FADD	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down	Young JA (2011), Young JA (2011), Young JA (2011)	3
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
NOS2	6	TRIM21	0	affinity chromatography technology	Foster MW (2013)	1
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
SQSTM1	0	CUL1	7	affinity chromatography technology	Tanji K (2012)	1
PAWR	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nguyen JQ (2017), Nguyen JQ (2017), Nguyen JQ (2017)	3
HDAC6	0	CFTR	5	affinity chromatography technology, affinity chromatography technology	Kawaguchi Y (2003), Ouyang H (2012)	2
IQCB1	3	SKP1	0	affinity chromatography technology	Sang L (2011)	1
RC3H1	6	UBE2D2	0	pull down	Zhang Q (2015)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
ZNF598	6	UBE2L3	1	affinity chromatography technology	Garzia A (2017)	1
NOS2	6	NPM1	0	affinity chromatography technology	Foster MW (2013)	1
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
HDAC6	0	TRIM21	0	affinity chromatography technology	Watson GW (2016)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
HDAC1	4	IRF5	0	affinity chromatography technology, pull down	Feng D (2010), Feng D (2010)	2
VCP	6	CALR	1	biochemical	Wan C (2015)	1
UBE2L3	1	NCOA1	6	affinity chromatography technology	Verma S (2004)	1
CUL1	7	YWHAZ	1	affinity chromatography technology	Bennett EJ (2010)	1
MAP1LC3C	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3B	1	TRIM21	0	pull down	Kimura T (2015)	1
ERG	1	NPM1	0	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
HDAC1	4	DAXX	5	far western blotting, pull down, affinity chromatography technology	Li H (2000), Li H (2000), Li H (2000)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
SKP2	2	CDC34	3	pull down, enzymatic study, pull down	Cen B (2010), Umanskaya K (2007), Ji P (2006)	3
FBXO6	0	YWHAG	5	affinity chromatography technology	Liu B (2012)	1
UBE2D2	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
CRBN	2	UBE2D1	0	pull down	Petzold G (2016)	1
UBE2H	3	HDAC6	0	enzymatic study	Hoeller D (2007)	1
NPM1	0	G3BP1	4	affinity chromatography technology	Hein MY (2015)	1
TRIM21	0	ULK1	8	affinity chromatography technology	Kimura T (2015)	1
IRF8	4	USP4	3	affinity chromatography technology, affinity chromatography technology	Lin R (2017), Lin R (2017)	2
HIST1H3E	0	PFKFB2	4	affinity chromatography technology	Campos EI (2015)	1
HDAC6	0	PAWR	2	affinity chromatography technology	Watson GW (2016)	1
ZNF598	6	PRMT5	3	affinity chromatography technology	Garzia A (2017)	1
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
MAP1LC3A	0	TRIM21	0	pull down	Kimura T (2015)	1
PAN2	3	TRIM21	0	affinity chromatography technology	Bett JS (2013)	1
CYLD	2	CDC5L	2	affinity chromatography technology	Elliott PR (2016)	1
HIST1H3E	0	NPM1	0	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
SQSTM1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
SQSTM1	0	ULK1	8	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ro SH (2014), Ro SH (2014), Lim J (2015), Lim J (2015)	4
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
USP2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CFTR	5	SQSTM1	0	imaging technique, affinity chromatography technology, biochemical	Luciani A (2010), Villella VR (2013), Villella VR (2013)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
ULK1	8	IRF3	4	affinity chromatography technology	Kimura T (2015)	1
MYC	2	UBE2L3	1	affinity chromatography technology	Shimura H (2001)	1
IFI35	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Das A (2015), Das A (2015)	2
CDK2	0	NPM1	0	enzymatic study	Tokuyama Y (2001)	1
IRF3	4	CBL	7	affinity chromatography technology, affinity chromatography technology	Zhao X (2016), Zhao X (2016)	2
SQSTM1	0	YWHAZ	1	pull down	Pridgeon JW (2004)	1
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
MAP1LC3C	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
TRIM21	0	UBE2C	1	pull down	Wada K (2006)	1
NMI	3	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Das A (2015), Das A (2015)	2
CDK2	0	UBE2I	0	affinity chromatography technology	Neganova I (2011)	1
CFTR	5	YWHAZ	1	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	TRIM5	4	affinity chromatography technology	Pankow S (2015)	1
HDAC6	0	NPM1	0	affinity chromatography technology	Watson GW (2016)	1
FADD	1	IRF7	2	affinity chromatography technology	Young JA (2011)	1
FBXO6	0	NPM1	0	affinity chromatography technology	Liu B (2012)	1
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
ZNF598	6	USP2	0	affinity chromatography technology	Morita M (2012)	1
GABARAPL2	0	YWHAZ	1	two hybrid	Vinayagam A (2011)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
ZNF598	6	BAG6	2	affinity chromatography technology	Garzia A (2017)	1
CDK2	0	MNAT1	0	affinity chromatography technology	Varjosalo M (2013)	1
CYLD	2	VCP	6	affinity chromatography technology	Elliott PR (2016)	1
FCGR2A	0	UBE2D2	0	affinity chromatography technology	Huttlin EL (2015)	1
SKP2	2	UBE2L3	1	affinity chromatography technology	Ma X (2017)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
HAUS2	2	HDAC1	4	affinity chromatography technology	Fogeron ML (2013)	1
RC3H1	6	NPM1	0	affinity chromatography technology	Murakawa Y (2015)	1
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
CDC5L	2	UBE2D1	0	affinity chromatography technology	Lleres D (2010)	1
USP15	4	TRIM5	4	two hybrid	Hayes SD (2012)	1
PAN2	3	NPM1	0	affinity chromatography technology	Bett JS (2013)	1
USP15	4	TRIM21	0	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
MAP1LC3B	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
VCP	6	TXN2	0	biochemical	Havugimana PC (2012)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
GMPS	1	TRIM21	0	affinity chromatography technology, affinity chromatography technology	Reddy BA (2014), Reddy BA (2014)	2
ZNF598	6	3500	0	affinity chromatography technology	Garzia A (2017)	1
SQSTM1	0	IRF8	4	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
MAP1LC3C	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
NPM1	0	USP15	4	affinity chromatography technology	Chen R (2013)	1
VCP	6	IQCB1	3	affinity chromatography technology	Yu CC (2013)	1
NANOG	0	CRBN	2	affinity chromatography technology	Oliviero G (2015)	1
CDK2	0	CALR	1	affinity chromatography technology	Neganova I (2011)	1
TRIM21	0	TRIM21	0	two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down, two hybrid, enzymatic study, two hybrid	Reymond A (2001), Wada K (2006), Takahata M (2008), Mallery DL (2010), Li X (2007), Ottosson L (2006), Wada K (2006), Rolland T (2014)	8
TRIM21	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
UBE2I	0	CFTR	5	enzymatic study, enzymatic study	Ahner A (2013), Gong X (2016)	2
PRMT5	3	TRIM21	0	affinity chromatography technology	Zhang HT (2016)	1
GABARAPL2	0	TRIM21	0	pull down	Kimura T (2015)	1
HDAC6	0	YWHAZ	1	enzymatic study	Mortenson JB (2015)	1
FBXO6	0	YWHAZ	1	affinity chromatography technology	Liu B (2012)	1
TRIM27	2	IKBKB	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
IQCB1	3	TRIM21	0	affinity chromatography technology	Sang L (2011)	1
TRIM21	0	CASP8AP2	3	two hybrid	Tanaka M (2010)	1
PAN2	3	RBCK1	0	two hybrid	Hayes SD (2012)	1
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
ERG	1	TRIM21	0	affinity chromatography technology	Brenner JC (2011)	1
DCP2	0	TRIM21	0	affinity chromatography technology, pull down, affinity chromatography technology	Yamochi T (2008), Yamochi T (2008), Yamochi T (2008)	3
USP2	0	MYC	2	enzymatic study	Gonzalez-Prieto R (2015)	1
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
CYLD	2	3500	0	affinity chromatography technology	Elliott PR (2016)	1
SKP1	0	UBE2D1	0	pull down, pull down	Kamura T (2000), Lin DI (2006)	2
UBE2H	3	DZIP3	6	two hybrid	Markson G (2009)	1
MAP1LC3A	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
UBE2D1	0	TRIM5	4	two hybrid	Markson G (2009)	1
CUL1	7	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
IRF8	4	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kong HJ (2007), Kong HJ (2007), Kong HJ (2007), Kong HJ (2007)	4
TRIM21	0	TXN2	0	two hybrid	Rolland T (2014)	1
FBXO6	0	PRMT5	3	affinity chromatography technology	Liu B (2012)	1
FADD	1	DAXX	5	affinity chromatography technology	Meinecke I (2007)	1
ULK1	8	GABARAP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Ewing RM (2007), Okazaki N (2000), Okazaki N (2000), Alemu EA (2012), Alemu EA (2012), Dunlop EA (2014)	6
MAP1LC3C	0	TRIM21	0	pull down	Kimura T (2015)	1
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
CDK2	0	CDC5L	2	enzymatic study	Boudrez A (2000)	1
TRIM21	0	DZIP3	6	two hybrid	Woodsmith J (2012)	1
MYC	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Koch HB (2007), von der Lehr N (2003), Wang J (2011)	3
TRIM21	0	CD52	0	affinity chromatography technology	Rhodes DA (2007)	1
TRIM21	0	ZFPM1	8	affinity chromatography technology	Rhodes DA (2007)	1
TRIM27	2	NIF3L1	0	two hybrid	Yu H (2011)	1
CDKN1B	1	MYC	2	affinity chromatography technology, protein complementation assay	Bahram F (2016), Bahram F (2016)	2
TRIM21	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
VCP	6	PRMT5	3	biochemical	Kristensen AR (2012)	1
BAG6	2	USP15	4	affinity chromatography technology	Hein MY (2015)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
IRF7	2	NMI	3	affinity chromatography technology, affinity chromatography technology	Wang J (2013), Wang J (2013)	2
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
NPM1	0	YWHAZ	1	affinity chromatography technology	Chen R (2013)	1
CDC34	3	CDKN1B	1	enzymatic study, unspecified method	Ryu KS (2008), Duda DM (2012)	2
TRIM21	0	UBE2L3	1	pull down	Wada K (2006)	1
CDC5L	2	GMPS	1	affinity chromatography technology	Lleres D (2010)	1
GABARAPL1	0	TRIM21	0	pull down	Kimura T (2015)	1
GAN	4	NPM1	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
MAP1LC3B	1	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
ZNF598	6	UBE2D2	0	affinity chromatography technology	Garzia A (2017)	1
NPM1	0	TRIM21	0	affinity chromatography technology	Chen R (2013)	1
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
CDKN1B	1	SKP1	0	unspecified method, unspecified method	Carrano AC (1999), Ooi LC (2013)	2
USP2	0	TRIM21	0	two hybrid	Hayes SD (2012)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
YWHAG	5	TRIM21	0	affinity chromatography technology	Jin J (2004)	1
CBL	7	YWHAZ	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Robertson H (1997), Subramanian RR (2001), Wang H (1998)	3
DCP2	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2014), Huttlin EL (2015), Huttlin EL (2017)	3
UBC	7	APC	5	affinity chromatography technology	Matsumoto M (2005)	1
CUL1	7	IRF3	4	affinity chromatography technology	Bibeau-Poirier A (2006)	1
NOS2	6	SKP1	0	affinity chromatography technology	Foster MW (2013)	1
DCAF4L2	3	TRIM21	0	affinity chromatography technology	Wang H (2016)	1
CYLD	2	YWHAZ	1	affinity chromatography technology	Elliott PR (2016)	1
YWHAZ	1	TRIM21	0	affinity chromatography technology	Jin J (2004)	1
PAN2	3	PRMT5	3	affinity chromatography technology	Bett JS (2013)	1
G3BP1	4	PAWR	2	affinity chromatography technology	Jain S (2016)	1
CYLD	2	NPM1	0	affinity chromatography technology	Elliott PR (2016)	1
BECN1	2	DZIP3	6	affinity chromatography technology	Behrends C (2010)	1
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
3500	0	TRIM21	0	x-ray crystallography, pull down, two hybrid	James LC (2007), James LC (2007), Rolland T (2014)	3
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
GAN	4	TRIM21	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
AGO4	5	PRMT5	3	affinity chromatography technology	Weinmann L (2009)	1
HDAC6	0	TRIM27	2	affinity chromatography technology	Joshi P (2013)	1
HAUS2	2	TRIM21	0	affinity chromatography technology	Fogeron ML (2013)	1
MAP1LC3A	0	GABARAPL1	0	imaging technique	Tanida I (2006)	1
FAIM2	2	TRIM21	0	pull down, affinity chromatography technology	Mueller J (2015), Mueller J (2015)	2
TRIM21	0	IKBKB	1	affinity chromatography technology, enzymatic study	Wada K (2009), Wada K (2009)	2
NCOA1	6	VCP	6	affinity chromatography technology	Jung SY (2005)	1
MAP1LC3B	1	UBE2L3	1	two hybrid, affinity chromatography technology	Gandini MA (2014), Gandini MA (2014)	2
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
BAG6	2	TRIM27	2	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
BECN1	2	NF2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HDAC6	0	IQCB1	3	affinity chromatography technology	Joshi P (2013)	1
FBXO6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Tian X (2015), Hauri S (2016)	9
NCOA1	6	TRIM21	0	affinity chromatography technology	Wu RC (2002)	1
UBE2I	0	DZIP3	6	two hybrid	Markson G (2009)	1
MNAT1	0	TRIM5	4	two hybrid	Woodsmith J (2012)	1
G3BP1	4	VCP	6	affinity chromatography technology	Jain S (2016)	1
VCP	6	MAP1LC3A	0	imaging technique	Wang Y (2011)	1
MNAT1	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
HIST1H3E	0	HDAC1	4	affinity chromatography technology	Campos EI (2015)	1
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
NF2	1	TRIM21	0	affinity chromatography technology	Zhou L (2015)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
DCAF4L2	3	PRMT5	3	affinity chromatography technology	Wang H (2016)	1
UBE2D1	0	HDAC6	0	enzymatic study	Hoeller D (2007)	1
UBE2D2	0	CDKN1B	1	enzymatic study	Ryu KS (2008)	1
TRIM21	0	SKP1	0	affinity chromatography technology, biochemical	Sabile A (2006), Sabile A (2006)	2
CFTR	5	PAWR	2	affinity chromatography technology	Pankow S (2015)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
CFTR	5	APC	5	affinity chromatography technology	Wang X (2006)	1
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
NCOA3	3	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Jung SY (2005)	7
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
SKP1	0	YWHAG	5	biochemical	Wan C (2015)	1
RC3H1	6	TRIM21	0	affinity chromatography technology	Murakawa Y (2015)	1
TRIM21	0	BECN1	2	affinity chromatography technology	Kimura T (2015)	1
CBL	7	UBE2D1	0	pull down, pull down, pull down	Umebayashi K (2008), Sehat B (2008), Tsukahara F (2010)	3
NPM1	0	HDAC1	4	affinity chromatography technology	Liu H (2007)	1
CBL	7	TRIM21	0	affinity chromatography technology	Brehme M (2009)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
UBC	7	PFKFB2	4	affinity chromatography technology	Matsumoto M (2005)	1
NOS2	6	YWHAG	5	affinity chromatography technology	Foster MW (2013)	1
SQSTM1	0	TRIM21	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim JY (2009), Kim JY (2009), Kimura T (2015), Milan E (2015), Pan JA (2016), Pan JA (2016)	6
USP4	3	IKBKB	1	affinity chromatography technology	Fan YH (2011)	1
VCP	6	TRIM21	0	affinity chromatography technology	Yu CC (2013)	1
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
ERG	1	CDC5L	2	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
NOS2	6	VCP	6	affinity chromatography technology	Foster MW (2013)	1
PRMT5	3	HDAC1	4	genetic interference	Wong AS (2016)	1
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
FBXW11	2	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
UBE2D2	0	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Yamauchi K (2008), Xu L (2003)	3
RC3H1	6	UBE2L3	1	pull down	Zhang Q (2015)	1
HDAC6	0	G3BP1	4	affinity chromatography technology, pull down	Kwon S (2007), Kwon S (2007)	2
CYLD	2	TRIM21	0	affinity chromatography technology	Elliott PR (2016)	1
CFTR	5	TRIM21	0	affinity chromatography technology	Pankow S (2015)	1
CUL1	7	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lleres D (2010)	2
CBL	7	UBE2L3	1	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Yokouchi M (1999), Zheng N (2000), Wong ES (2002), Wong ES (2002), Oved S (2006), Dominguez C (2004)	6
NPM1	0	VCP	6	affinity chromatography technology	Chen R (2013)	1
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1
CDKN1B	1	CUL1	7	unspecified method, pull down	Carrano AC (1999), Enchev RI (2012)	2