Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
STAT3 6774 ACITRETIN CHEMBL1131 inhibitor TTD
STAT3 6774 ATIPRIMOD CHEMBL103735 inhibitor TTD
STAT3 6774 BARDOXOLONE METHYL CHEMBL1762621 inhibitor TTD

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
STAT3 rs4796793 GG interferons efficacy yes IFN-alpha. Careful- GC SNP. Based on dbSNP population frequencies in Asians(and orientation of dbSNP exemplar sequence and FastA sequence compared to + Golden Path strand), I reversed the designations used in the article, but I'm not completely sure this is correct. Also, the p I've entered is not adjusted for multiple testing, and if adjusted: 0.0039 * 423(for tested SNPs) = 1.6. [stat_test: pearson's chi square] Genotype GG is associated with increased response to interferons in people with Carcinoma, Renal Cell as compared to genotypes CC + CG. 17602083 769169630