Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
TCF7L2	6934	REPAGLINIDE	CHEMBL1272		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TCF7L2	rs12255372	TT	sulfonamides, urea derivatives	efficacy	yes		Genotype TT is associated with decreased response to sulfonamides, urea derivatives in people with Diabetes Mellitus, Type 2 as compared to genotype GG.	17519421	699639389
TCF7L2	rs290487	TT	repaglinide	efficacy	yes		Genotype TT is associated with increased response to repaglinide in people with Diabetes Mellitus, Type 2 as compared to genotypes CC + CT.	20054294	655385762
TCF7L2	rs7903146	TT	sulfonamides, urea derivatives	efficacy	yes		Genotype TT is associated with decreased response to sulfonamides, urea derivatives in people with Diabetes Mellitus, Type 2 as compared to genotype CC.	17519421	827826067
TCF7L2	rs7903146	T	metformin	efficacy	yes	as measured by decreases in fasting glucose compared to pre-treatment in people with risk factors for type 2 diabetes.	Allele T is associated with increased response to metformin as compared to allele C.	29326107	1451105843
TCF7L2	rs7903146	T	glipizide	efficacy	yes	as measured by shorter time and a steeper slope to trough glucose levels in people with risk factors for type 2 diabetes.	Allele T is associated with increased response to glipizide as compared to allele C.	29326107	1451105880