PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBL	7	PTPN11	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanaka Y (2008), Tanaka Y (2008), Hoff H (2007), Chernock RD (2001), Chernock RD (2001)	5
TIE1	6	TEK	2	affinity chromatography technology	Marron MB (2000)	1
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
TEK	2	PTK2	2	imaging technique	Moon HE (2015)	1
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
CBL	7	TEK	2	affinity chromatography technology	Wehrle C (2009)	1
TEK	2	STYX	1	two hybrid	Yao Z (2017)	1
TEK	2	APP	1	pull down	Olah J (2011)	1
TEK	2	ANGPT1	0	pull down, affinity chromatography technology, pull down, pull down, pull down	Fiedler U (2003), Fiedler U (2003), Davis S (1996), Sato A (1998), Maisonpierre PC (1997)	5
MAPK3	4	ILKAP	2	biochemical	Wan C (2015)	1
PTK2	2	PTPN11	20	affinity chromatography technology, affinity chromatography technology	Manes S (1999), Takahashi A (2011)	2
IKBKG	0	TEK	2	pull down	Fenner BJ (2010)	1
TEK	2	AKT1	1	imaging technique	Moon HE (2015)	1
TEK	2	DUSP18	0	two hybrid	Yao Z (2017)	1
TIE1	6	ANGPT4	1	pull down	Valenzuela DM (1999)	1
TEK	2	PTPN11	20	two hybrid	Yao Z (2017)	1
MAPK3	4	TEK	2	affinity chromatography technology	Varjosalo M (2013)	1
TEK	2	ANGPT4	1	pull down	Valenzuela DM (1999)	1
PTK2	2	APP	1	pull down	Olah J (2011)	1
TNIP2	1	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, two hybrid	Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Liu WK (2004), Wang J (2011)	6
TEK	2	TEK	2	enzymatic study	Smith BD (2015)	1
CBL	7	PTK2	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Schmidt MH (2003), Sekine Y (2007)	3
DOK2	2	TEK	2	affinity chromatography technology, affinity chromatography technology	Jones N (1998), Master Z (2001)	2
AKT1	1	APP	1	pull down	Olah J (2011)	1
TEK	2	PTPRR	3	two hybrid	Yao Z (2017)	1
TNIP2	1	APP	1	pull down	Olah J (2011)	1
TEK	2	TNIP2	1	two hybrid, affinity chromatography technology	Hughes DP (2003), Hughes DP (2003)	2
TEK	2	ANGPT2	4	pull down, affinity chromatography technology, pull down, pull down, pull down	Fiedler U (2003), Fiedler U (2003), Sato A (1998), Maisonpierre PC (1997), Lee HS (2014)	5
TEK	2	ILKAP	2	two hybrid	Yao Z (2017)	1