PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSMA3	1	CFTR	5	biochemical, affinity chromatography technology	Oberdorf J (2006), Pankow S (2015)	2
VKORC1	1	TF	2	two hybrid	Schaafhausen A (2011)	1
TF	2	IGF2	1	pull down, pull down	Storch S (2001), Storch S (2001)	2
GLRA2	4	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	TF	2	affinity chromatography technology	Agrawal P (2010)	1
IGFBP3	1	FN1	17	pull down, two hybrid, pull down, affinity chromatography technology	Martin JA (2002), Gui Y (2001), Gui Y (2001), Gui Y (2001)	4
CA8	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMA3	1	CALR	1	affinity chromatography technology	Fedorova OA (2011)	1
MAPK6	1	C3	7	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	TF	2	two hybrid	Wang J (2008)	1
CFTR	5	CALR	1	affinity chromatography technology	Pankow S (2015)	1
FN1	17	TFRC	1	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	TF	2	affinity chromatography technology	Moussavi-Harami SF (2013)	1
GDPD1	0	C3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CALR	1	TF	2	pull down	Wada I (1997)	1
CFTR	5	TF	2	affinity chromatography technology	Pankow S (2015)	1
GRB2	2	SH2D4A	0	two hybrid	Bandyopadhyay S (2010)	1
IGF2	1	IGFBP3	1	pull down, pull down, pull down, pull down	Storch S (2001), Buckway CK (2001), Twigg SM (1998), Firth SM (1998)	4
ESR1	0	UTP3	0	affinity chromatography technology	Tarallo R (2011)	1
MYC	2	FN1	17	affinity chromatography technology	Agrawal P (2010)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
DDX31	1	C3	7	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	C3	7	affinity chromatography technology	Pankow S (2015)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
ESR1	0	TFRC	1	affinity chromatography technology	Tarallo R (2011)	1
MATN3	2	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EDIL3	1	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAMC3	9	TF	2	two hybrid	Wang J (2011)	1
ESR1	0	TF	2	affinity chromatography technology	Tarallo R (2011)	1
DDX19B	2	RAB5A	0	affinity chromatography technology	Huttlin EL (2015)	1
FN1	17	C3	7	affinity chromatography technology	Moussavi-Harami SF (2013)	1
IGF1	0	IGFBP3	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Liu B (2003), Ueki I (2000), Buckway CK (2001), Buckway CK (2001), Cohen P (1992), Twigg SM (1998), Firth SM (1998)	7
SNX27	5	TF	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK6	1	CALR	1	two hybrid	Vinayagam A (2011)	1
SNX27	5	3503	0	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	RAB5A	0	affinity chromatography technology, affinity chromatography technology	Bomberger JM (2009), Pankow S (2015)	2
TF	2	IGF1	0	pull down	Storch S (2001)	1
CFTR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosser MF (2008), Wang X (2006), Pankow S (2015)	3
ALDH2	2	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMA3	1	TF	2	affinity chromatography technology	Fedorova OA (2011)	1
FNBP1	0	TF	2	imaging technique	Kamioka Y (2004)	1
MIS12	0	TF	2	affinity chromatography technology	Hutchins JR (2010)	1
CA8	0	C3	7	affinity chromatography technology	Huttlin EL (2017)	1
TUBB3	3	TF	2	two hybrid	Stelzl U (2005)	1
CANX	4	TF	2	pull down	Wada I (1997)	1
GDPD1	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK6	1	TF	2	affinity chromatography technology	Huttlin EL (2017)	1
CALR	1	CANX	4	affinity chromatography technology	Oliver JD (1999)	1
SYT17	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
RAB5A	0	TF	2	biochemical	Li Q (2006)	1
3503	0	TF	2	affinity chromatography technology	Boldt K (2016)	1
SMAD3	1	TF	2	two hybrid	Wang J (2011)	1
STPG2	5	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDX19B	2	C3	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TYRP1	5	TF	2	biochemical	Li Q (2006)	1
SNX27	5	C3	7	affinity chromatography technology	Huttlin EL (2017)	1
SH2D4A	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TYRP1	5	RAB5A	0	biochemical	Li Q (2006)	1
CCDC82	2	TF	2	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	PSMA3	1	affinity chromatography technology	Koch HB (2007)	1
DDX19B	2	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TF	2	TIMELESS	8	two hybrid	Wang J (2011)	1
IGFBP3	1	TF	2	affinity chromatography technology, pull down	Weinzimer SA (2001), Weinzimer SA (2001)	2
CFTR	5	SNX27	5	affinity chromatography technology	Pankow S (2015)	1
ALDH2	2	3503	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	TUBB3	3	affinity chromatography technology	Pankow S (2015)	1
UTP3	0	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C3	7	TF	2	affinity chromatography technology	Boldt K (2016)	1
TFR2	3	TF	2	pull down	West AP (2000)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
DDX31	1	TF	2	affinity chromatography technology	Huttlin EL (2017)	1
SLC38A6	2	TF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFRC	1	TF	2	pull down	West AP (2000)	1