Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
TLR5	7100	ENTOLIMOD	CHEMBL2108683	agonist	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TLR5	rs5744174	AG	Tumor necrosis factor alpha	efficacy	yes	When comparing responders against non-responders. However, no association was seen when comparing the GG vs AA genotype or the AG+GG vs AA genotype. Additionally, no association was seen when comparing responders vs. partial responders for any genotype.	Genotype AG is associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Crohn Disease as compared to genotype AA.	28139755	1448604108
TLR5	rs5744174	AG + GG	ustekinumab	efficacy	yes	Good responders (those with a reduction of >=75% in PASI score after 3 months) were compared against non-responders (those with a reduction of <50% in PASI score after 3 months). Statistical results adjusted for age, gender, psoriatic arthritis and previous treatments and corrected for multiple testing using the false discovery rate. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes AG + GG is associated with increased response to ustekinumab in people with Psoriasis as compared to genotype AA.	28696418	1449155460