PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF2	1	TNFRSF9	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Jang IK (1998), Jang IK (1998), Jang IK (1998), Arch RH (1998), Arch RH (1998), Ma BY (2005), Martinez-Forero I (2013), Saoulli K (1998), Saoulli K (1998)	9
SDCBP	0	TRAF5	1	two hybrid	Rolland T (2014)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
TRAF5	1	NUMBL	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Tao T (2012), Tao T (2012), Wang J (2011)	3
ELAVL1	0	ZMYND11	10	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
TRAF5	1	CCDC184	1	two hybrid	Rolland T (2014)	1
TRAF5	1	ENOX2	1	two hybrid	Rolland T (2014)	1
CCDC40	6	TRAF5	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	SMURF1	4	genetic interference	Li S (2010)	1
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
COG5	4	COG7	2	pull down, pull down, biochemical, biochemical, biochemical, affinity chromatography technology	Loh E (2004), Loh E (2004), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
TRIM8	6	TRAF5	1	two hybrid	Woodsmith J (2012)	1
TRAF5	1	MAP3K14	1	affinity chromatography technology	Song HY (1997)	1
COMMD3	0	TRAF5	1	two hybrid	Wang J (2011)	1
TNFRSF13B	0	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
TICAM1	3	TRAF5	1	affinity chromatography technology	Jiang Z (2004)	1
NGFR	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ye X (1999), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Gentry JJ (2004), Geetha T (2012), Geetha T (2012)	7
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
RIPK2	0	TRAF5	1	affinity chromatography technology	McCarthy JV (1998)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
TRIM27	2	RIPK1	2	affinity chromatography technology	Zaman MM (2013)	1
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
TNFRSF13B	0	TRAF3	1	affinity chromatography technology	Xu LG (2002)	1
CD40	3	TRAF5	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Ishida TK (1996), Werneburg BG (2001), Peters AL (2010), Mizushima S (1998), Basaki Y (2002), He B (2010), Hostager BS (2010), Hostager BS (2010)	9
TICAM1	3	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
TRAF3IP2	0	UBC	7	enzymatic study	Liu C (2009)	1
TRIM27	2	TBK1	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TNFRSF4	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Arch RH (1998), Arch RH (1998), Ma BY (2005)	3
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
LTBR	0	SDCBP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	SRSF1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF2	1	ZMYND11	10	affinity chromatography technology	Ikeda O (2010)	1
TICAM1	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Piao W (2009), Sato S (2003), Sato S (2003), Hu YH (2015), Cai B (2017)	6
RIPK2	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hasegawa M (2008), Kim JY (2008), Yang Y (2007), Yang Y (2007), Windheim M (2007)	5
TRAF5	1	THAP1	1	two hybrid	Rolland T (2014)	1
TRAF3	1	TNFRSF4	1	affinity chromatography technology	Ma BY (2005)	1
TRAF6	0	NUMBL	1	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhou L (2010), Zhou L (2010), Tao T (2012), Wang J (2011), Swarnkar G (2017)	5
TRAIP	0	MAP3K7	2	affinity chromatography technology	Kong QZ (2016)	1
TRAF5	1	GORASP2	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	EIF2AK2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SEC13	0	TRAF5	1	two hybrid	Rolland T (2014)	1
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
SDCBP	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen F (2008), Chen F (2008)	2
TRAF5	1	TRAF3IP2	0	affinity chromatography technology, affinity chromatography technology	Sun D (2011), Sun D (2011)	2
NGFR	3	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Zhou X (2016), Zhou X (2016), Zhou X (2016)	3
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
TNFRSF11A	2	TRAF5	1	pull down, pull down, pull down, affinity chromatography technology	Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Wong BR (1998)	4
TRAF3	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
TNFRSF4	1	TRAF5	1	affinity chromatography technology, pull down, affinity chromatography technology	Kawamata S (1998), Kawamata S (1998), Ma BY (2005)	3
USP7	14	TRAF6	0	pull down, affinity chromatography technology, enzymatic study	Zapata JM (2001), Daubeuf S (2009), Bremm A (2010)	3
TRAF5	1	TNFRSF9	1	affinity chromatography technology	Ma BY (2005)	1
TRAIP	0	TBK1	1	affinity chromatography technology	Zhang M (2012)	1
ELAVL1	0	TRIM37	7	affinity chromatography technology	Abdelmohsen K (2009)	1
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
TNFRSF13B	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), Kanno Y (2010), He B (2010)	4
TNFRSF11A	2	TRAF6	0	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mizukami J (2002), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998), Lin J (2015), Yu J (2016)	9
MAVS	1	TRAF5	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Tang ED (2010), Minassian A (2015), Khan M (2016)	4
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TRIM27	2	SDCBP	0	two hybrid	Rolland T (2014)	1
TRAF5	1	RORC	4	affinity chromatography technology, affinity chromatography technology	Wang X (2015), Wang X (2015)	2
TRAF5	1	COG7	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
TRAF5	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999)	2
LTBR	0	TRAF3	1	affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	VanArsdale TL (1997), Wu MY (1999), Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Mosialos G (1995), Li C (2003), Li C (2003), Force WR (1997), Force WR (1997), Huttlin EL (2015), Huttlin EL (2017)	12
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
USP7	14	TRAF5	1	pull down	Zapata JM (2001)	1
UBC	7	SDCBP	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MDM2	2	TRAF5	1	two hybrid	Woodsmith J (2012)	1
TNFRSF17	0	TRAF6	0	affinity chromatography technology	He B (2010)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
SMURF1	4	TBK1	1	enzymatic study	Andrews PS (2010)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
LTBR	0	ZMYND11	10	two hybrid, affinity chromatography technology	Liu HP (2011), Liu HP (2011)	2
TRAF5	1	TBK1	1	affinity chromatography technology, pull down	Fang R (2017), Fang R (2017)	2
TRAF3	1	RIPK2	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Cai X (2013), Cai X (2013), Cai X (2013), Cai X (2013)	4
TRAF2	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
RIPK1	2	TRAF5	1	affinity chromatography technology	Tada K (2001)	1
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
MAP3K5	1	MAP3K7	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochida Y (2000), Mochida Y (2000), Mochida Y (2000), Kim SY (2012), Kim SY (2012)	5
TRAF6	0	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAF6	0	UBE2O	5	affinity chromatography technology, affinity chromatography technology	Zhang X (2013), Zhang X (2013)	2
TRAF2	1	NFATC2IP	2	affinity chromatography technology	Lieberson R (2001)	1
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
TRAF5	1	COG5	4	affinity chromatography technology	Li S (2011)	1
CD27	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998), Gravestein LA (1998), Huttlin EL (2015), Huttlin EL (2017)	5
ZMYND11	10	SRSF1	0	affinity chromatography technology	Guo R (2014)	1
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
TRAF5	1	ZFAND6	0	two hybrid	Rolland T (2014)	1
TRAF3IP2	0	MAP3K7	2	affinity chromatography technology	Qian Y (2007)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
CAPNS1	0	TRAF5	1	two hybrid	Wang J (2011)	1
ELAVL1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
TRAF2	1	ZFAND6	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Chang EJ (2011), Chang EJ (2011), Chang EJ (2011), Huttlin EL (2017)	5
LTBR	0	TRAF5	1	pull down, pull down, pull down	Marsters SA (1997), Li C (2003), Mizushima S (1998)	3
MAP3K14	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Ninomiya-Tsuji J (1999), Hofer-Warbinek R (2000)	2
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
TNFRSF13B	0	TRAF5	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
TRAF6	0	NFATC2IP	2	affinity chromatography technology	Lieberson R (2001)	1
ELAVL1	0	CD27	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF5	1	NFATC2IP	2	affinity chromatography technology	Lieberson R (2001)	1
TRAF5	1	UBC	7	enzymatic study	Middleton AJ (2017)	1
TRAF3	1	NFATC2IP	2	affinity chromatography technology	Lieberson R (2001)	1
TRAF5	1	SRSF1	0	affinity chromatography technology	Sun D (2011)	1
ZMYND11	10	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wan J (2006), Ikeda O (2010)	2
HSD17B10	1	TRAF6	0	two hybrid	Narayan SB (2012)	1
TRAF2	1	TNFRSF17	0	affinity chromatography technology	Hatzoglou A (2000)	1
TNFRSF9	1	TRAF3	1	pull down, affinity chromatography technology	Jang IK (1998), Ma BY (2005)	2
TNFRSF14	2	TRAF3	1	pull down	Marsters SA (1997)	1
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
NGFR	3	TRAF5	1	affinity chromatography technology	Ye X (1999)	1
USP7	14	TRIM8	6	two hybrid, two hybrid	Hayes SD (2012), Wang J (2011)	2
EIF2AK2	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF8	2	TRAF2	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Aizawa S (1997), Aizawa S (1997), Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Horie R (2002), Huttlin EL (2017)	7
HOMER1	1	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF3IP2	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
TNFRSF11A	2	TRAF2	1	pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Darnay BG (1998), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	7
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
TNFRSF11A	2	MAP3K7	2	affinity chromatography technology	Mizukami J (2002)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
TRAF3IP2	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Qu F (2012), Qu F (2012), Qu F (2012)	3
TNFRSF8	2	TRAF5	1	pull down, affinity chromatography technology, pull down	Aizawa S (1997), Aizawa S (1997), Mizushima S (1998)	3
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TRAF3	1	MAP3K5	1	affinity chromatography technology	Nishitoh H (1998)	1
TRAF3	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
CD27	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Yamamoto H (1998), Akiba H (1998)	2
TRAF3	1	ZMYND11	10	affinity chromatography technology, pull down	Ikeda O (2010), Ikeda O (2010)	2
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
CD40	3	TRAF3	1	pull down, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsukamoto N (1999), Hu HM (1994), Hu HM (1994), Hu HM (1994), Ni CZ (2000), Roy N (1997), Qiao G (2007), Mosialos G (1995), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Li C (2003), Boucher LM (1997), Graham JP (2009), Sato T (1995), Sato T (1995), Sato T (1995), Deregibus MC (2003), Hostager BS (1999), Basaki Y (2002), Cheng G (1995), Miliara S (2013), Elmetwali T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	27
TRAIP	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Besse A (2007), Zhang M (2012)	2
TRAF2	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
MAP3K7	2	EIF2AK2	1	affinity chromatography technology	Jiang Z (2003)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
HSD17B10	1	TRAF3IP2	0	two hybrid	Narayan SB (2012)	1
TRAF3	1	TNFRSF17	0	affinity chromatography technology	Hatzoglou A (2000)	1
UBE2O	5	TRIM27	2	two hybrid	Markson G (2009)	1
MAP3K7	2	TRIM8	6	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), Li Q (2011), Chen L (2017), Chen L (2017), Yan FJ (2016), Yan FJ (2016)	6
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
TRAF5	1	ZMYND11	10	affinity chromatography technology	Ikeda O (2010)	1
RAD23A	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Brignone C (2004), Brignone C (2004), Brignone C (2004)	3
TRAF3	1	SMURF1	4	genetic interference	Li S (2010)	1
RAD23A	1	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Fang DF (2013), Fang DF (2013), Rolland T (2014), Akhtar N (2016)	5
SERPINB9	0	TRAF5	1	two hybrid	Rolland T (2014)	1
TRAF5	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRIM37	7	TRAF3	1	pull down	Zapata JM (2001)	1
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
TRAF5	1	NMI	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDM2	2	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010)	3
HSD17B10	1	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
TNFRSF11A	2	TRAF3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF2	1	GORASP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RNF111	2	TRAF5	1	two hybrid	Woodsmith J (2012)	1
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
TRAF5	1	TRAF5	1	affinity chromatography technology, two hybrid, two hybrid	Pullen SS (1998), Woodsmith J (2012), Rolland T (2014)	3
NGFR	3	TRAF2	1	affinity chromatography technology, pull down	Ye X (1999), Ye X (1999)	2
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
EIF2AK2	1	TRAF5	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gil J (2004)	2
TRAF3	1	TBK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kayagaki N (2007), Mankouri J (2010), Mankouri J (2010), Tzieply N (2012), Wang Y (2012), Ng MH (2011), Charoenthongtrakul S (2013), van Zuylen WJ (2012), van Zuylen WJ (2012), Karim R (2013), Chen X (2014), Peng Y (2014), Wang S (2013), Zhou Y (2016), Cai B (2017), Fang R (2017), Fang R (2017)	17
MAVS	1	EIF2AK2	1	affinity chromatography technology	Arnaud N (2011)	1
TRAF3IP2	0	SRSF1	0	affinity chromatography technology, affinity chromatography technology	Herjan T (2013), Sun D (2011)	2
TNFRSF9	1	TNFRSF4	1	affinity chromatography technology, affinity chromatography technology	Ma BY (2005), Ma BY (2005)	2
NUMBL	1	RIPK1	2	two hybrid	Wang J (2011)	1
TNFRSF8	2	TRAF3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gedrich RW (1996), Gedrich RW (1996), Boucher LM (1997), Huttlin EL (2017)	4
TRAF5	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
TRAF5	1	SMURF1	4	genetic interference	Li S (2010)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
TRIM37	7	TRAF5	1	pull down	Zapata JM (2001)	1
TRIM37	7	TRAF6	0	pull down	Zapata JM (2001)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
DGKH	5	TRAF5	1	two hybrid	Wang J (2011)	1
SMURF1	4	RAD23A	1	enzymatic study	Andrews PS (2010)	1
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
TNFRSF17	0	TRAF5	1	affinity chromatography technology	He B (2010)	1
FBXO28	2	TRAF5	1	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF8	2	TRAIP	0	affinity chromatography technology	Lee SY (1997)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
CD40	3	TDP2	2	two hybrid, affinity chromatography technology	Pype S (2000), Pype S (2000)	2
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
CD27	1	TRAF5	1	affinity chromatography technology	Akiba H (1998)	1
TNFRSF8	2	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAF5	1	ELAVL1	0	affinity chromatography technology	Herjan T (2013)	1
TRAF5	1	UBE2O	5	affinity chromatography technology	Zhang X (2013)	1
EIF2AK2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology	Takizawa T (2002), Takizawa T (2002)	2
NGFR	3	TRAF3	1	affinity chromatography technology	Ye X (1999)	1
TRAF3IP2	0	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Herjan T (2013), Herjan T (2013)	2
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
SMURF1	4	SRSF1	0	affinity chromatography technology	Xie Y (2013)	1
USP7	14	TRAF3	1	pull down	Zapata JM (2001)	1
RAD23A	1	TRAF5	1	two hybrid	Rolland T (2014)	1
LZTS2	4	TRAF5	1	affinity chromatography technology	Huttlin EL (2015)	1
TRAIP	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007), Park ES (2015)	4
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
TRAF2	1	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology	Gil J (2004), Gao L (2015)	2
UBC	7	SRSF1	0	affinity chromatography technology	Matsumoto M (2005)	1
LTBR	0	TRIM37	7	pull down	Zapata JM (2001)	1
TRAF2	1	TDP2	2	affinity chromatography technology	Pype S (2000)	1
TRAIP	0	TRAF5	1	affinity chromatography technology	Besse A (2007)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
TRAF3IP2	0	CD40	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian Y (2002), Qian Y (2004), Boisson B (2013)	3
NGFR	3	TRIM37	7	pull down	Zapata JM (2001)	1
TRAF2	1	SRSF1	0	affinity chromatography technology	Sun D (2011)	1
HSD17B10	1	TRAF5	1	two hybrid	Narayan SB (2012)	1
TNFRSF14	2	TRAF2	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
MAP3K14	1	TRAF3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Sanjo H (2010), Sanjo H (2010), Song HY (1997), Hu WH (2004), Liao G (2004), Liao G (2004), Choudhary S (2013), Lee S (2014), Huttlin EL (2017)	10
TRAF3	1	RIPK1	2	affinity chromatography technology	Hsu H (1996)	1
UBC	7	UBE2O	5	affinity chromatography technology	Bish RA (2007)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
UBC	7	ZFAND6	0	pull down, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Fenner BJ (2009), Nathan JA (2013), Zhang X (2017)	4
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
TRAF2	1	FBXO28	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
TRAF2	1	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Nishitoh H (1998), Hoeflich KP (1999), Gan B (2006), Kolliputi N (2009), Fujino G (2007), Fujino G (2007), Wu Y (2006), Zhang H (2004), Hwang SG (2014), Yoon KW (2009), Yoon KW (2009)	11
SMURF1	4	MAVS	1	affinity chromatography technology	Wang Y (2012)	1
TNFRSF14	2	TRAF5	1	two hybrid, affinity chromatography technology, pull down	Hsu H (1997), Hsu H (1997), Marsters SA (1997)	3
HOMER1	1	TRAF5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2