PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ITPR1	25	TRPC3	0	affinity chromatography technology	Yuan JP (2003)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
ITPR1	25	TRPC4	3	affinity chromatography technology, two hybrid	Yuan JP (2003), Mery L (2001)	2
TRPC3	0	TRPC6	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
ITPR3	9	TRPC7	4	pull down	Tang J (2001)	1
TRPC1	0	TRPC3	0	affinity chromatography technology, affinity chromatography technology	Struebing C (2003), Xu XZ (1997)	2
TRPC6	3	TRPC7	4	fluorescent resonance energy transfe	Hofmann T (2002)	1
SRC	2	TRPC6	3	affinity chromatography technology	Hisatsune C (2004)	1
TRPC4	3	TRPC1	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002), Hofmann T (2002)	3
TRPC5	5	TRPC4	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
ITPR3	9	TRPC3	0	pull down	Tang J (2001)	1
7221	0	TRPC6	3	affinity chromatography technology, affinity chromatography technology	Chu X (2004), Chu X (2004)	2
TRPC4	3	TRPC3	0	affinity chromatography technology	Struebing C (2003)	1
ITPR3	9	TRPC6	3	pull down	Tang J (2001)	1
TRPC1	0	ITPR3	9	affinity chromatography technology, pull down, affinity chromatography technology	Singh BB (2000), Tang J (2001), Sundivakkam PC (2009)	3
ITPR1	25	ITPR3	9	biochemical	Joseph SK (1995)	1
ITPR1	25	7221	0	affinity chromatography technology	Yuan JP (2003)	1
ITPR3	9	TRPC5	5	pull down	Tang J (2001)	1
ITPR3	9	TRPC4	3	pull down, two hybrid	Tang J (2001), Mery L (2001)	2
TRPC3	0	TRPC7	4	fluorescent resonance energy transfe	Hofmann T (2002)	1
TRPC6	3	RNF24	0	two hybrid, affinity chromatography technology	Lussier MP (2008), Lussier MP (2008)	2
TRPC1	0	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
ITPR1	25	TRPC1	0	affinity chromatography technology	Yuan JP (2003)	1
TRPC5	5	TRPC3	0	affinity chromatography technology	Struebing C (2003)	1
TRPC6	3	FYN	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hisatsune C (2004), Hisatsune C (2004), Hisatsune C (2004), Hisatsune C (2004)	4
TRPC4	3	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
TRPC5	5	TRPC1	0	affinity chromatography technology, fluorescent resonance energy transfe	Struebing C (2003), Hofmann T (2002)	2
ITPR3	9	7221	0	pull down	Tang J (2001)	1
ITPR1	25	TRPC6	3	affinity chromatography technology	Yuan JP (2003)	1
TRPC5	5	TRPC6	3	affinity chromatography technology	Struebing C (2003)	1
TRPC6	3	TRPC6	3	affinity chromatography technology, fluorescent resonance energy transfe	Hofmann T (2002), Hofmann T (2002)	2
ITPR1	25	TRPC5	5	affinity chromatography technology	Yuan JP (2003)	1