PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	ARIH1	3	affinity chromatography technology	Ertych N (2016)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
UBE2E2	1	MID1	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014), Yu H (2011)	5
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
ARRDC3	0	NEDD4L	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
CHFR	5	HDAC2	1	affinity chromatography technology, pull down	Oh YM (2009), Oh YM (2009)	2
TRIM32	2	UBE2E2	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
RNF185	1	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	DTX3L	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SRPK2	1	UBE2E2	1	enzymatic study	Varjosalo M (2013)	1
CUL3	17	USP15	4	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	TRIM45	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	DDA1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E2	1	DTX3L	1	two hybrid	Markson G (2009)	1
BRCA1	7	HDAC2	1	pull down, affinity chromatography technology, genetic interference	Yarden RI (1999), Chang S (2011), Shen JP (2017)	3
ARIH1	3	CUL3	17	affinity chromatography technology	Kelsall IR (2013)	1
TRIM50	1	UBE2E2	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
DET1	2	MDM2	2	affinity chromatography technology	Pick E (2007)	1
ELAVL1	0	MID1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC2	1	RUNX1T1	1	affinity chromatography technology	Amann JM (2001)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
ARIH2	4	TRIM27	2	two hybrid	Woodsmith J (2012)	1
STUB1	4	UBE2E2	1	pull down, pull down	Xu Z (2008), Soss SE (2011)	2
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2E2	1	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
BARD1	4	SRPK2	1	affinity chromatography technology	Woods NT (2012)	1
UBA1	1	UBE2E2	1	enzymatic study, pull down	Tokgoez Z (2012), Jin J (2007)	2
UBE2E2	1	RING1	2	two hybrid	Markson G (2009)	1
UBE2E2	1	RNF11	0	two hybrid	Markson G (2009)	1
UBE2E2	1	CHFR	5	two hybrid	Markson G (2009)	1
UBE2E2	1	TRIM2	1	two hybrid	Markson G (2009)	1
ELAVL1	0	TRIM37	7	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E2	1	PCGF2	3	two hybrid	van Wijk SJ (2009)	1
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
NFE2L2	1	HDAC2	1	affinity chromatography technology	Lee DY (2012)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
SIAH1	2	RLIM	1	affinity chromatography technology	Kraemer OH (2008)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
UNG	1	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	RNF4	1	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	PTBP2	1	affinity chromatography technology, two hybrid, two hybrid	Abdelmohsen K (2009), Hegele A (2012), Hegele A (2012)	3
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
UBE2E2	1	HDAC2	1	affinity chromatography technology	Kraemer OH (2008)	1
ARIH1	3	UBE2E2	1	pull down	Moynihan TP (1999)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E2	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ito K (2001), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Ito K (2001)	5
UBE2E2	1	APP	1	pull down	Olah J (2011)	1
UBE2E2	1	UBOX5	4	two hybrid	Markson G (2009)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
HNRNPL	3	USP15	4	affinity chromatography technology	Fei T (2017)	1
RBX1	2	UBE2E2	1	pull down	Shibata E (2011)	1
DET1	2	UBE2E2	1	affinity chromatography technology	Huttlin EL (2017)	1
SRPK1	2	UBE2E2	1	enzymatic study	Varjosalo M (2013)	1
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
DTL	0	UBE2E2	1	affinity chromatography technology	Shibata E (2011)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
RING1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	SRPK1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL3	17	TRIM28	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SRPK2	1	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
MDM2	2	RNF10	0	two hybrid	Woodsmith J (2012)	1
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
UBE2E2	1	ARRDC3	0	two hybrid	Rolland T (2014)	1
UBE2E2	1	MKRN3	2	two hybrid	Markson G (2009)	1
MARCH3	0	APP	1	pull down	Olah J (2011)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
DTL	0	MDM2	2	affinity chromatography technology	Banks D (2006)	1
UBE2E2	1	RNF2	1	two hybrid	Markson G (2009)	1
ELAVL1	0	DAZAP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MDM2	2	UBE2E2	1	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
SPEN	22	UBE2E2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Li J (2006), Li J (2006), Li J (2006), Li J (2006)	4
MDM2	2	XIAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Gu L (2009), Huang X (2013), Huang X (2013), Huang X (2013), Liu T (2015)	5
PDLIM2	0	UBE2E2	1	pull down	Tanaka T (2005)	1
UBE2E2	1	RNF114	0	two hybrid	Markson G (2009)	1
TRIM28	1	UBE2E2	1	pull down	Doyle JM (2010)	1
RNF11	0	APP	1	pull down	Olah J (2011)	1
OTUB1	0	UBE2E2	1	affinity chromatography technology, affinity chromatography technology	Scholz CC (2016), Huttlin EL (2017)	2
HNRNPL	3	BARD1	4	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	PTBP2	1	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2E2	1	MARCH3	0	two hybrid	Markson G (2009)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
UBE2E2	1	TRIM23	3	two hybrid	Markson G (2009)	1
TRIM23	3	SIAH1	2	two hybrid	Rolland T (2014)	1
HNRNPL	3	XIAP	0	affinity chromatography technology	Fei T (2017)	1
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
RNF11	0	NEDD4L	3	two hybrid	Colland F (2004)	1
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
SPEN	22	RUNX1T1	1	unspecified method, affinity chromatography technology, biochemical, two hybrid	Salat D (2008), Salat D (2008), Salat D (2008), Salat D (2008)	4
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
MDM2	2	RNF8	2	two hybrid	Woodsmith J (2012)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
PTBP2	1	UBE2E2	1	biochemical	Havugimana PC (2012)	1
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
NEDD4L	3	UBE2E2	1	pull down	Todaro DR (2017)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E2	1	ARIH2	4	two hybrid	Markson G (2009)	1
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
UBE2E2	1	FAM9B	0	two hybrid	Rolland T (2014)	1
PCGF2	3	RING1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elderkin S (2007), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Yu H (2011), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
MID2	1	UBE2E2	1	two hybrid, two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014)	3
HNRNPL	3	MID2	1	affinity chromatography technology	Fei T (2017)	1
UBE2E2	1	RNF166	0	two hybrid	Markson G (2009)	1
RLIM	1	MDM2	2	affinity chromatography technology, pull down, pull down, enzymatic study	Gao K (2016), Gao K (2016), Gao K (2016), Gao K (2016)	4
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2E2	1	NFE2L2	1	pull down	Plafker KS (2010)	1
UBE2E2	1	RNF10	0	two hybrid	Markson G (2009)	1
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
ELAVL1	0	TRIM38	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E2	1	RNF125	0	two hybrid	Markson G (2009)	1
ELAVL1	0	TRIM2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E2	1	SIAH1	2	pull down, affinity chromatography technology, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008), Lee JT (2008)	3
PRKN	1	ARIH1	3	affinity chromatography technology	Parelkar SS (2012)	1
UBE2E2	1	DDA1	1	affinity chromatography technology	Pick E (2007)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
SRPK2	1	SPEN	22	enzymatic study	Lipp JJ (2015)	1
UBE2E2	1	RLIM	1	two hybrid, affinity chromatography technology	Markson G (2009), Kraemer OH (2008)	2
UBE2E2	1	RNF111	2	two hybrid	Markson G (2009)	1
UBE2E2	1	UNG	1	biochemical	Havugimana PC (2012)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E2	1	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2E2	1	RNF185	1	two hybrid	Markson G (2009)	1
MDM2	2	ARIH2	4	affinity chromatography technology, affinity chromatography technology	Bae S (2012), Bae S (2012)	2
UBE2E2	1	CUL3	17	pull down	Plafker KS (2009)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
UBE2E2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ramsey CP (2010), Shimura H (2000), Im E (2015), Kazlauskaite A (2014)	4
UBE2E2	1	DZIP3	6	two hybrid, two hybrid	Markson G (2009), Yu H (2011)	2
HNRNPL	3	ARIH1	3	affinity chromatography technology	Fei T (2017)	1
UBE2E2	1	PRAM1	4	pull down, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	RC3H2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM37	7	UBE2E2	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
RNF2	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
CUL3	17	SRPK1	2	affinity chromatography technology	Bennett EJ (2010)	1
TRIM45	1	UBE2E2	1	two hybrid	Napolitano LM (2011)	1
BRCA1	7	NFE2L2	1	affinity chromatography technology, affinity chromatography technology	Gorrini C (2013), Gorrini C (2013)	2
UBE2E2	1	TRIM31	0	two hybrid	Napolitano LM (2011)	1
DDA1	1	DTL	0	affinity chromatography technology	Olma MH (2009)	1
UBE2E2	1	RNF25	1	two hybrid, affinity chromatography technology	Markson G (2009), Huttlin EL (2017)	2
SRPK2	1	APP	1	pull down	Olah J (2011)	1
TRIM27	2	RBX1	2	two hybrid	Woodsmith J (2012)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
MUL1	1	UBE2E2	1	two hybrid	Ambivero CT (2014)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2E2	1	RNF14	2	two hybrid, two hybrid, pull down, two hybrid	Ito K (2001), Markson G (2009), Ito K (2001), Ambivero CT (2014)	4
BARD1	4	FAM9B	0	two hybrid	Rolland T (2014)	1
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
UBE2E2	1	RUNX1T1	1	pull down, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
SRPK2	1	RNF4	1	enzymatic study	Varjosalo M (2013)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
RUNX1T1	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	UBE2E2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	PCGF2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
RC3H2	5	UBE2E2	1	pull down	Zhang Q (2015)	1
UBE2E2	1	UBE2E2	1	enzymatic study	David Y (2010)	1
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
TRIM27	2	PRAM1	4	affinity chromatography technology, two hybrid, two hybrid	Cao T (1998), Cao T (1998), Rolland T (2014)	3
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
MDM2	2	USP15	4	pull down	Liu WT (2016)	1
DAZAP2	1	NEDD4L	3	two hybrid	Rolland T (2014)	1
TRIM39	0	APP	1	pull down	Olah J (2011)	1
UBE2E2	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
UBE2E2	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
DET1	2	RNF14	2	affinity chromatography technology	Pick E (2007)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
DET1	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pick E (2007), Pick E (2007), Pick E (2007), Olma MH (2009), Pick E (2007), Huttlin EL (2017)	6
UBE2E2	1	DTX3	4	two hybrid	Markson G (2009)	1
RNF4	1	NFE2L2	1	affinity chromatography technology	Malloy MT (2013)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
HNRNPL	3	UBE2E2	1	affinity chromatography technology	Fei T (2017)	1
UBE2E2	1	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2E2	1	XIAP	0	two hybrid	Markson G (2009)	1
HDAC2	1	RLIM	1	affinity chromatography technology	Brandl A (2012)	1
TRIM31	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
RUNX1T1	1	MID2	1	two hybrid	Rolland T (2014)	1
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
DDA1	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
HNRNPL	3	NEDD4L	3	affinity chromatography technology	Fei T (2017)	1
BARD1	4	UBE2E2	1	pull down	David Y (2011)	1
CUL3	17	TRIM32	2	affinity chromatography technology	Wimuttisuk W (2014)	1
UBE2E2	1	USP15	4	affinity chromatography technology	Huttlin EL (2017)	1
PCGF2	3	RNF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elderkin S (2007), Elderkin S (2007), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Gao Z (2012), Endoh M (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Taherbhoy AM (2015), Taherbhoy AM (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	15
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
DET1	2	RBX1	2	affinity chromatography technology	Wertz IE (2004)	1
RNF103	1	UBE2E2	1	two hybrid, two hybrid	Scheper J (2009), Ambivero CT (2014)	2
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
IPO11	0	UBE2E2	1	pull down	Plafker SM (2004)	1
NFE2L2	1	TRIM28	1	biochemical, imaging technique	Gjyshi O (2015), Gjyshi O (2015)	2
TRIM38	3	UBE2E2	1	two hybrid	Napolitano LM (2011)	1
BARD1	4	SRPK1	2	affinity chromatography technology	Woods NT (2012)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1
UBE2E2	1	TRIM27	2	two hybrid	Napolitano LM (2011)	1
BRCA1	7	UBE2E2	1	two hybrid, x-ray crystallography, pull down, two hybrid, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011)	5