PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
USP1	4	CALML5	0	affinity chromatography technology	Sowa ME (2009)	1
FZR1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2A	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lyakhovich A (2003), Lyakhovich A (2003), Chen S (2012), Chen S (2012), Read ML (2014), An H (2017)	6
USP1	4	DSG1	1	affinity chromatography technology	Sowa ME (2009)	1
SOCS6	0	USP1	4	affinity chromatography technology	Huttlin EL (2015)	1
USP1	4	USP4	3	affinity chromatography technology	Sowa ME (2009)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
PHLPP2	5	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cukras S (2016), St-Denis N (2016)	3
FZR1	1	UBE2K	0	pull down	Jin L (2008)	1
WDR48	2	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	PCNA	0	pull down	Cohn MA (2007)	1
UNC45A	1	WDR5	2	biochemical	Havugimana PC (2012)	1
CERK	4	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
USP1	4	CALML3	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	LYZ	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	DSC1	2	affinity chromatography technology	Sowa ME (2009)	1
SYNCRIP	6	USP1	4	affinity chromatography technology	Hein MY (2015)	1
TOR1AIP1	2	USP1	4	affinity chromatography technology	Hein MY (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
USP1	4	USP1	4	affinity chromatography technology	Lee KY (2010)	1
UBE2A	0	USP1	4	biochemical	Havugimana PC (2012)	1
WDR48	2	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Lee KY (2010), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Villamil MA (2012), Garcia-Santisteban I (2012), Garcia-Santisteban I (2012), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Cohn MA (2007), Lehoux M (2014), Lehoux M (2014), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016)	25
USP1	4	JUP	7	affinity chromatography technology	Sowa ME (2009)	1
RAD51AP1	1	JUP	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ID2	0	USP1	4	affinity chromatography technology, affinity chromatography technology	Williams SA (2011), Williams SA (2011)	2
USP1	4	VPS36	3	biochemical	Havugimana PC (2012)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
USP1	4	PHF7	5	two hybrid	Hayes SD (2012)	1
WDR5	2	CSE1L	1	biochemical	Havugimana PC (2012)	1
FZR1	1	USP1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Cataldo F (2013), Cotto-Rios XM (2011), Cotto-Rios XM (2011), Cotto-Rios XM (2011)	4
UBE2A	0	SYNCRIP	6	affinity chromatography technology	An H (2017)	1
USP1	4	VPS26A	0	biochemical	Havugimana PC (2012)	1
PKP1	2	DSC1	2	two hybrid	Cheng X (2004)	1
BAG6	2	USP1	4	affinity chromatography technology	Hein MY (2015)	1
KPNA1	5	FANCD2	3	biochemical	Wan C (2015)	1
SGTB	2	USP1	4	affinity chromatography technology	Hein MY (2015)	1
USP1	4	DTX3	4	two hybrid	Hayes SD (2012)	1
FANCD2	3	FZR1	1	affinity chromatography technology, affinity chromatography technology	Lai F (2012), Lai F (2012)	2
USP1	4	FANCD2	3	affinity chromatography technology, enzymatic study, biochemical	Nijman SM (2005), Cohn MA (2007), Nijman SM (2005)	3
USP43	1	USP1	4	affinity chromatography technology	Hein MY (2015)	1
USP1	4	TRIM46	3	two hybrid	Hayes SD (2012)	1
ANAPC1	1	USP1	4	affinity chromatography technology	Cotto-Rios XM (2011)	1
SORT1	1	SYNCRIP	6	affinity chromatography technology	Hein MY (2015)	1
CERK	4	USP1	4	affinity chromatography technology	Hein MY (2015)	1
UNC45A	1	CSE1L	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SGTB	2	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
CAPNS1	0	USP1	4	affinity chromatography technology, affinity chromatography technology	Cataldo F (2013), Cataldo F (2013)	2
USP1	4	TRAF6	0	two hybrid	Hayes SD (2012)	1
USP1	4	PCNA	0	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Huang TT (2006), Hibbert RG (2012), Juhasz S (2012), Cotto-Rios XM (2011)	4
FZR1	1	ANAPC1	1	pull down, unspecified method, affinity chromatography technology	Vodermaier HC (2003), Vodermaier HC (2003), Huttlin EL (2017)	3
ATAD5	5	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Yang K (2011), Liang F (2016)	3
WDR48	2	UBC	7	x-ray crystallography	Yin J (2015)	1
RSRP1	0	USP1	4	affinity chromatography technology	Hein MY (2015)	1
USP1	4	MYH9	19	affinity chromatography technology	Sowa ME (2009)	1
VPS26A	0	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
MYH9	19	JUP	7	affinity chromatography technology	Hein MY (2015)	1
USP1	4	CSE1L	1	biochemical	Havugimana PC (2012)	1
RAD51AP1	1	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Huttlin EL (2017)	4
USP4	3	PCNA	0	enzymatic study	Clerici M (2014)	1
SORT1	1	USP1	4	affinity chromatography technology	Hein MY (2015)	1
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
JUP	7	DSC1	2	two hybrid	Cheng X (2004)	1
AKT1	1	HSPB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Wu R (2007), Rane MJ (2003), Rane MJ (2003), Rane MJ (2003)	9
USP1	4	ATAD5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Lee KY (2010), Rahman S (2011)	3
USP1	4	304	0	affinity chromatography technology	Sowa ME (2009)	1
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
PHLPP1	4	PHLPP2	5	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), St-Denis N (2016)	2
DSG1	1	DSC1	2	pull down	Smith EA (1998)	1
KATNA1	0	USP1	4	affinity chromatography technology	Hein MY (2015)	1
WDR5	2	TRAF6	0	affinity chromatography technology	Wang YY (2010)	1
USP1	4	STAT2	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	DTX3	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBC	7	SYNCRIP	6	affinity chromatography technology	Matsumoto M (2005)	1
TP53	0	LYZ	0	affinity chromatography technology	Horikawa I (2014)	1
USP1	4	UBC	7	enzymatic study, pull down	Faesen AC (2011), Cohn MA (2009)	2
CSE1L	1	KPNA1	5	pull down	Koehler M (1999)	1
USP1	4	TAGLN2	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	UNC45A	1	biochemical	Havugimana PC (2012)	1
UBC	7	HSPB1	2	affinity chromatography technology	Matsumoto M (2005)	1
DSG1	1	PKP1	2	pull down	Smith EA (1998)	1
WDR48	2	RAD51AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016), Liang F (2016), Liang F (2016)	9
USP1	4	KPNA1	5	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hein MY (2015)	2
MYH9	19	UNC45A	1	affinity chromatography technology	Hein MY (2015)	1
TRAF6	0	USP4	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Xiao N (2011), Xiao N (2011), Xiao N (2011), Xiao N (2011), Zhou F (2012), Zhou F (2012)	6
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
AKT1	1	FANCD2	3	affinity chromatography technology	Zhang X (2016)	1
USP1	4	ALDH16A1	4	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	FLG	17	affinity chromatography technology	Sowa ME (2009)	1
VPS26A	0	VPS36	3	biochemical	Havugimana PC (2012)	1
AKT1	1	USP4	3	pull down, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
AKT1	1	USP1	4	affinity chromatography technology	Zhang X (2016)	1
FZR1	1	TP53	0	enzymatic study	Gmachl M (2000)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
USP1	4	HSPB1	2	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	WDR5	2	pull down, pull down	Dou Y (2005), Tang Z (2013)	2
PHLPP1	4	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mistafa O (2010), Gao T (2005), Gao T (2005), Zhang X (2016)	4
UBE2A	0	PCNA	0	enzymatic study	Unk I (2006)	1
USP1	4	PKP1	2	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	ANAPC1	1	pull down	Nathan JA (2013)	1
USP1	4	WDR5	2	biochemical	Havugimana PC (2012)	1
USP1	4	UBE2K	0	enzymatic study	Das DS (2017)	1
USP1	4	LRRC15	2	affinity chromatography technology	Huttlin EL (2017)	1
LGALS7	0	USP4	3	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	ATAD5	5	pull down, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Lee KY (2010), Hein MY (2015)	3
MYH9	19	CALML3	0	affinity chromatography technology	Hein MY (2015)	1
TP53	0	USP1	4	genetic interference	Xie L (2013)	1
DSG1	1	JUP	7	pull down	Smith EA (1998)	1
WDR48	2	PHLPP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), Cukras S (2016), St-Denis N (2016), St-Denis N (2016), Gangula NR (2013), Gangula NR (2013), Gangula NR (2013), Gangula NR (2013)	10
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
HSPB1	2	STAT2	2	affinity chromatography technology	Gibert B (2012)	1
UBE2A	0	CSE1L	1	biochemical	Havugimana PC (2012)	1
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
PHLPP1	4	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Zhiqiang Z (2012), Zhiqiang Z (2012), Zhiqiang Z (2012), Cukras S (2016), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Gangula NR (2013)	10
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBC	7	WDR5	2	affinity chromatography technology	Matsumoto M (2005)	1
USP1	4	KRT17	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	LGALS7	0	affinity chromatography technology	Sowa ME (2009)	1
BAG6	2	FANCD2	3	affinity chromatography technology	Hein MY (2015)	1
USP1	4	KRT4	0	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	PHLPP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), Cukras S (2016), St-Denis N (2016), Yadav L (2017)	6
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
VPS36	3	UBC	7	x-ray crystallography, pull down, pull down	Alam SL (2006), Alam SL (2006), Langelier C (2006)	3
TP53	0	MYH9	19	affinity chromatography technology	Horikawa I (2014)	1