PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPL	6	VIM	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Kazerounian S (2002), van den Heuvel AP (2002), van den Heuvel AP (2002), van den Heuvel AP (2002), Rolland T (2014)	5
VIM	0	VIM	0	two hybrid, x-ray crystallography, x-ray crystallography, two hybrid, two hybrid	Stelzl U (2005), Strelkov SV (2002), Strelkov SV (2001), Vinayagam A (2011), Goehler H (2004)	5
YWHAQ	0	VIM	0	affinity chromatography technology, pull down, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010)	3
YWHAZ	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Tzivion G (2000), Tzivion G (2000), Tzivion G (2000)	3
PLA2G2A	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Boilard E (2003), Boilard E (2003), Boilard E (2003)	3
GAN	4	NEFL	1	affinity chromatography technology	Johnson-Kerner BL (2015)	1
AKT1	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu QS (2011), Zhu QS (2011), Zhu QS (2011), Zhu QS (2011)	4
VIM	0	CRMP1	0	two hybrid, pull down, two hybrid	Vinayagam A (2011), Goehler H (2004), Goehler H (2004)	3
AKT1	1	PPL	6	two hybrid, pull down, affinity chromatography technology, two hybrid	Wang J (2008), van den Heuvel AP (2002), van den Heuvel AP (2002), van den Heuvel AP (2002)	4
GAN	4	VIM	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Huttlin EL (2017)	4
NEFL	1	VIM	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Goehler H (2004), Huttlin EL (2017), Boldt K (2016)	3
TSGA10	0	VIM	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roghanian A (2010), Roghanian A (2010), Roghanian A (2010)	3
PKN1	4	VIM	0	two hybrid, enzymatic study, two hybrid	Matsuzawa K (1997), Matsuzawa K (1997), Rolland T (2014)	3
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
PKN1	4	NEFL	1	two hybrid, pull down	Mukai H (1996), Mukai H (1996)	2
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
VIM	0	KAT7	3	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Goehler H (2004)	4