Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
TRPV1 7442 GRC-6211 CHEMBL3545107 antagonist, blocker ChemblInteractions, TTD
TRPV1 7442 CHEMBL164813 CHEMBL164813 activator GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL254778 CHEMBL254778 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 AMG-517 CHEMBL229430 antagonist, blocker, channel blocker GuideToPharmacologyInteractions, ChemblInteractions, TTD
TRPV1 7442 PAC-14028 CHEMBL3707398 antagonist ChemblInteractions
TRPV1 7442 LINOLENIC ACID CHEMBL8739 DrugBank 17139284, 17016423
TRPV1 7442 ICOSAPENT CHEMBL460026 inducer DrugBank 17038422
TRPV1 7442 CAPSAICIN CHEMBL294199 agonist, activator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank, TTD 21852280, 21158551
TRPV1 7442 PROPOFOL CHEMBL526 NCI 12760991
TRPV1 7442 CHEMBL441472 CHEMBL441472 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL195789 CHEMBL195789 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL104028 CHEMBL104028 blocker, channel blocker GuideToPharmacologyInteractions, TTD
TRPV1 7442 AZD1386 CHEMBL3545039 antagonist, inhibitor, blocker GuideToPharmacologyInteractions, ChemblInteractions, TTD
TRPV1 7442 PHE377 CHEMBL3545148 antagonist ChemblInteractions
TRPV1 7442 DWP05195 CHEMBL3545229 antagonist ChemblInteractions
TRPV1 7442 SAF312 CHEMBL3544953 inhibitor ChemblInteractions
TRPV1 7442 ZUCAPSAICIN CHEMBL313971 TdgClinicalTrial
TRPV1 7442 ACETAMINOPHEN CHEMBL112 ChemblInteractions
TRPV1 7442 RESINIFERATOXIN CHEMBL448382 activator TdgClinicalTrial, GuideToPharmacologyInteractions, TTD
TRPV1 7442 CAMPHOR CHEMBL504760 activator GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL2386188 CHEMBL2386188 activator GuideToPharmacologyInteractions
TRPV1 7442 CAPSAZEPINE CHEMBL391997 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 RUTHENIUM RED CHEMBL2068405 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 IODORESINIFERATOXIN CHEMBL595069 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 ALLICIN CHEMBL359965 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 ABT-102 CHEMBL398338 antagonist, blocker ChemblInteractions, TTD
TRPV1 7442 NGD-8243 CHEMBL3545227 antagonist, blocker TdgClinicalTrial, ChemblInteractions, TTD
TRPV1 7442 XEN-D0501 CHEMBL3707293 antagonist ChemblInteractions
TRPV1 7442 MAVATREP CHEMBL2364618 antagonist ChemblInteractions
TRPV1 7442 WORTMANNIN CHEMBL428496 NCI 17074976
TRPV1 7442 ANANDAMIDE CHEMBL15848 activator GuideToPharmacologyInteractions
TRPV1 7442 OLVANIL CHEMBL76903 activator GuideToPharmacologyInteractions
TRPV1 7442 PIPERINE CHEMBL43185 activator GuideToPharmacologyInteractions
TRPV1 7442 GADOBENATE DIMEGLUMINE CHEMBL1200571 activator GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL120735 CHEMBL120735 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 SB-705498 CHEMBL207433 antagonist, blocker, channel blocker GuideToPharmacologyInteractions, ChemblInteractions, TTD
TRPV1 7442 CHEMBL169233 CHEMBL169233 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 CHEMBL122413 CHEMBL122413 channel blocker GuideToPharmacologyInteractions
TRPV1 7442 JTS-653 CHEMBL3545228 antagonist ChemblInteractions
TRPV1 7442 SYL-1001 CHEMBL3707356 antagonist ChemblInteractions
TRPV1 7442 MR-1817 CHEMBL3707397 antagonist ChemblInteractions
TRPV1 7442 STAUROSPORINE CHEMBL388978 NCI 18463260
TRPV1 7442 ASPARTAME CHEMBL171679 inducer DrugBank 17567713
TRPV1 7442 INDOMETHACIN CHEMBL6 NCI 15831443
TRPV1 7442 LEVODOPA CHEMBL1009 NCI 16806299
TRPV1 7442 RESERPINE CHEMBL772 NCI 16806299
TRPV1 7442 STREPTOZOTOCIN CHEMBL1651906 NCI 18089839

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TRPV1 rs222747 C botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Allele C is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele G. 31014225 1451104980
TRPV1 rs224534 AA + AG acetaminophen efficacy yes Volunteers who had a higher pain threshold with acetaminophen treatment compared to placebo were designated as responders. Genotypes AA + AG is associated with increased response to acetaminophen in healthy individuals as compared to genotype GG. 30908574 1450374073
TRPV1 rs222749 A botulinum toxin type a efficacy yes The A allele was found at a significantly higher frequency in non-responders than in responders. Note that this variant was not present at Hardy-Weinberg equilibrium in the study cohort (p=0.00006). Allele A is associated with decreased response to botulinum toxin type a in women with Migraine NOS as compared to allele G. 31014225 1451104645
TRPV1 rs222741 G botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Please note that alleles have been complemented to the positive strand. Allele G is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele A. 31014225 1451105001