Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
WRN	7486	BLEOMYCIN (CHEMBL3039590)	CHEMBL3039590		NCI	15149862
WRN	7486	UREA	CHEMBL985		NCI	17312972
WRN	7486	CAMPTOTHECIN	CHEMBL65		NCI	17303082

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
WRN	rs2725335	A	fluorouracil	efficacy	no	1,002 patients with gastric cancer and complete genotyping data were included; 694 had chemotherapy treatment, and 308 did not. Median follow-up time was 63.43 months, with 465 deaths (46.4%) at the end. Patients were treated with fluoropyridines, platinum-based chemotherapy, or radiotherapy combinations. Please note: the authors do not distinguish between distinct treatment regimens- simply "chemotherapy".	Allele A is not associated with response to fluorouracil, Platinum compounds and radiotherapy in people with Stomach Neoplasms as compared to allele G.	28796378	1448926669
WRN	rs1346044	C	fluorouracil	efficacy	no	1,002 patients with gastric cancer and complete genotyping data were included; 694 had chemotherapy treatment, and 308 did not. Median follow-up time was 63.43 months, with 465 deaths (46.4%) at the end. Patients were treated with fluoropyridines, platinum-based chemotherapy, or radiotherapy combinations. Please note: the authors do not distinguish between distinct treatment regimens- simply "chemotherapy".	Allele C is not associated with response to fluorouracil, Platinum compounds and radiotherapy in people with Stomach Neoplasms as compared to allele T.	28796378	1448926660