PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	WDR48	2	affinity chromatography technology	Emdal KB (2015)	1
H2AFX	1	DHX9	3	affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Mischo HE (2005)	3
POLL	3	RPA1	0	affinity chromatography technology	Boldt K (2016)	1
CDC5L	2	PRKDC	12	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
MUS81	1	WEE1	2	affinity chromatography technology	Dominguez-Kelly R (2011)	1
BLM	2	CHAF1A	1	far western blotting, affinity chromatography technology, two hybrid	Jiao R (2004), Jiao R (2004), Jiao R (2004)	3
ATR	6	RPA2	0	enzymatic study, affinity chromatography technology	Olson E (2006), Marechal A (2014)	2
TP53	0	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Romanova LY (2004), Romanova LY (2004), Riva F (2001), Glanzer JG (2013)	4
DHX9	3	XRCC5	5	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2005), Zhang S (2004), Zhang S (2004), Zhang S (2004), Sand-Dejmek J (2011)	5
SIRT1	3	WRN	6	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Law IK (2009), Law IK (2009), Li K (2008), Li K (2008), Li K (2008), Li K (2008)	6
RPA1	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
PRKDC	12	CHEK2	2	enzymatic study	Chan DW (2000)	1
NTRK1	1	WRN	6	affinity chromatography technology	Emdal KB (2015)	1
SUMO2	0	ATRX	7	pull down	Ouyang J (2009)	1
WRN	6	PML	7	affinity chromatography technology	Liu J (2011)	1
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
WRN	6	POT1	2	genetic interference	Takahashi K (2010)	1
RPA3	2	RAD51	3	two hybrid	Du Y (2009)	1
POLR1C	2	WRN	6	affinity chromatography technology	Shiratori M (2002)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
ARL3	1	TP53	0	two hybrid, genetic interference	Stelzl U (2005), Xie L (2013)	2
ATR	6	WRN	6	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Otterlei M (2006), Patro BS (2011), Patro BS (2011)	4
RPA3	2	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
POLK	0	RPA1	0	affinity chromatography technology, imaging technique	Ogi T (2010), Ogi T (2010)	2
TP53	0	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Al Rashid ST (2005), Al Rashid ST (2005)	2
PCNA	0	SUMO1	0	pull down	Moldovan GL (2012)	1
XRCC6	3	TINF2	1	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	WRNIP1	3	affinity chromatography technology	Lleres D (2010)	1
PRKDC	12	WRN	6	unspecified method, affinity chromatography technology, enzymatic study	Kim ST (1999), Karmakar P (2002), Karmakar P (2002)	3
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
BLM	2	WRN	6	affinity chromatography technology, pull down	von Kobbe C (2002), von Kobbe C (2002)	2
CHEK1	2	XRCC5	5	affinity chromatography technology	Goudelock DM (2003)	1
WRN	6	WRN	6	pull down	Cooper MP (2000)	1
WDR48	2	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
PRKDC	12	RPA2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Shao RG (1999), Shao RG (1999), Shao RG (1999), Wu X (2006), Zernik-Kobak M (1997), Chan DW (2000), Marechal A (2014), Fried LM (1996)	8
BLM	2	TERF2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Opresko PL (2002), Bhattacharyya S (2009), Lillard-Wetherell K (2004), Lillard-Wetherell K (2004)	4
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
CHEK2	2	PML	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang S (2002), Yang S (2002), Yang S (2002)	3
WDR48	2	PCNA	0	pull down	Cohn MA (2007)	1
ATR	6	NBN	1	unspecified method, pull down, affinity chromatography technology	Kim ST (1999), Falck J (2005), Falck J (2005)	3
ATRX	7	RPA1	0	affinity chromatography technology	Leung JW (2013)	1
SUMO2	0	XRCC6	3	pull down	Ouyang J (2009)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
RAD51	3	PML	7	affinity chromatography technology	Boichuk S (2011)	1
ATM	9	TERF2	2	affinity chromatography technology, pull down	Karlseder J (2004), Karlseder J (2004)	2
PCNA	0	CHEK1	2	affinity chromatography technology	Scorah J (2008)	1
TUBA1A	13	BLM	2	genetic interference	Srivas R (2016)	1
BLM	2	ATRX	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Srivastava V (2009), Srivastava V (2009), Srivastava V (2009), Srivastava V (2009)	4
ATM	9	CHEK1	2	unspecified method, enzymatic study, genetic interference	Kim ST (1999), Sorensen CS (2003), Shen JP (2017)	3
VCP	6	SUMO1	0	affinity chromatography technology	Yu CC (2013)	1
CREBBP	29	MDC1	8	affinity chromatography technology, affinity chromatography technology, pull down	Townsend K (2009), Townsend K (2009), Townsend K (2009)	3
CDC5L	2	SUMO1	0	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	CHEK1	2	affinity chromatography technology	Lleres D (2010)	1
H2AFX	1	PML	7	affinity chromatography technology	Dittmann K (2011)	1
PCNA	0	DHX9	3	affinity chromatography technology	Takasaki Y (2001)	1
TINF2	1	PRKDC	12	affinity chromatography technology	Hein MY (2015)	1
TUBA1A	13	CHEK2	2	genetic interference	Srivas R (2016)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
RPA2	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shao RG (1999), Shao RG (1999), Marechal A (2014), Wan C (2015)	4
CHEK2	2	WEE1	2	genetic interference	Srivas R (2016)	1
TP53	0	BLM	2	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004), Wang XW (2001), Wang XW (2001), Wang XW (2001), Wang XW (2001), Garkavtsev IV (2001), Garkavtsev IV (2001), Yang Q (2002), Yang Q (2002), Wang J (2013)	12
WEE1	2	BLM	2	genetic interference	Srivas R (2016)	1
POLL	3	RPA3	2	affinity chromatography technology	Boldt K (2016)	1
WRN	6	CREBBP	29	affinity chromatography technology	Li K (2008)	1
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
MDC1	8	PRKDC	12	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Lou Z (2004), Lou Z (2004), Lou Z (2004), Lou Z (2004)	4
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
XRCC5	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Ohta S (2002), Balajee AS (2001)	3
TUBA1A	13	WRN	6	genetic interference	Srivas R (2016)	1
ARL3	1	WRN	6	affinity chromatography technology	Boldt K (2016)	1
WRN	6	CHAF1A	1	far western blotting, far western blotting, imaging technique, affinity chromatography technology, affinity chromatography technology	Jiao R (2007), Jiao R (2007), Jiao R (2007), Jiao R (2007), Jiao R (2007)	5
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
PRKDC	12	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, affinity chromatography technology	Shao RG (1999), Drouet J (2005), Gottlieb TM (1993), Shamanna RA (2011), Shamanna RA (2011), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Hein MY (2015)	9
POLK	0	WRN	6	pull down	Maddukuri L (2014)	1
BLM	2	RPA1	0	pull down, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brosh RM (2000), Opresko PL (2002), Moens PB (2002), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Wang J (2013), Marechal A (2014), Chaudhury I (2014), Elia AE (2015)	10
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
CHAF1A	1	PCNA	0	pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moggs JG (2000), Rolef Ben-Shahar T (2009), Gerard A (2006), Gerard A (2006), Gerard A (2006), Naryzhny SN (2005), Sarraf SA (2004), Hoek M (2011), Hoek M (2011), Takami Y (2007), Hein MY (2015)	11
MDC1	8	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, pull down, affinity chromatography technology, imaging technique	Xu X (2003), Goldberg M (2003), Goldberg M (2003), Lukas C (2004), Cha H (2010), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Lou Z (2004), Hari FJ (2010), Lu CS (2012), Wu L (2008), Wu L (2008), Wu L (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008), Chapman JR (2008)	18
XRCC6	3	TERF2	2	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song K (2000), Song K (2000), Song K (2000), Lee OH (2011), Hein MY (2015)	5
NTRK1	1	PRKDC	12	affinity chromatography technology	Emdal KB (2015)	1
CDKN2A	1	WRN	6	pull down, affinity chromatography technology, affinity chromatography technology	Woods YL (2004), Woods YL (2004), Woods YL (2004)	3
RPA2	0	RAD52	5	affinity chromatography technology	Jackson D (2002)	1
WRN	6	XRCC5	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar P (2002), Karmakar P (2002), Li B (2000), Cooper MP (2000), Cooper MP (2000), Cooper MP (2000), Orren DK (2001), Li B (2004), Li B (2004), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Partridge JJ (2003), Partridge JJ (2003), Hein MY (2015)	14
ATRX	7	WRN	6	far western blotting	Otterlei M (2006)	1
ATRX	7	TP53	0	affinity chromatography technology, unspecified method	Leung JW (2013), Li Z (2017)	2
RAD52	5	RPA3	2	affinity chromatography technology, affinity chromatography technology	Du Y (2009), Du Y (2009)	2
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
RPA1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
RPA3	2	XRCC6	3	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	XRCC6	3	affinity chromatography technology	Marechal A (2014)	1
MUS81	1	CREBBP	29	genetic interference	Vizeacoumar FJ (2013)	1
MDC1	8	ATM	9	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Xu X (2003), Kolas NK (2007), Stewart GS (2003), Stewart GS (2003), Rassoolzadeh H (2015)	5
ATRX	7	H2AFX	1	imaging technique	Choi EH (2017)	1
WRN	6	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Partridge JJ (2003), Partridge JJ (2003), Indig FE (2004)	3
MUS81	1	WRN	6	genetic interference	Vizeacoumar FJ (2013)	1
XRCC5	5	NBN	1	affinity chromatography technology	Falck J (2005)	1
RAD51	3	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, pull down, far western blotting	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006)	5
CREBBP	29	XRCC6	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Barlev NA (1998), Barlev NA (1998), Cohen HY (2004), Cohen HY (2004), Cohen HY (2004)	5
NTRK1	1	RPA1	0	affinity chromatography technology	Emdal KB (2015)	1
RAD51	3	SUMO1	0	two hybrid	Shen Z (1996)	1
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
RPA2	0	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO2	0	NBN	1	pull down	Ouyang J (2009)	1
RPA2	0	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
SKAP1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA3	2	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Boldt K (2016)	2
MDC1	8	XRCC5	5	pull down, affinity chromatography technology	Lou Z (2004), Lou Z (2004)	2
CHEK2	2	WRN	6	genetic interference	Srivas R (2016)	1
MDC1	8	H2AFX	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, imaging technique	Stewart GS (2003), Stewart GS (2003), Xu X (2003), Lukas C (2004), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Pan MR (2011), Pei H (2011), Campbell SJ (2010), Rassoolzadeh H (2015)	13
ATR	6	TP53	0	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, genetic interference	Fabbro M (2004), Kim ST (1999), Lin WC (2001), Wang X (2011), Lakin ND (1999), Rocha S (2005), Dodson GE (2006), Kim ST (1999), Xie L (2013)	9
ATRX	7	XRCC6	3	affinity chromatography technology	Leung JW (2013)	1
RPA3	2	PARP1	3	affinity chromatography technology	Marechal A (2014)	1
PCNA	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ohta S (2002), Ohta S (2002), Balajee AS (2001), Nicolae CM (2014)	4
RPA2	0	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	DHX9	3	affinity chromatography technology	Marechal A (2014)	1
CDC5L	2	FEN1	1	affinity chromatography technology	Lleres D (2010)	1
H2AFX	1	RAD51	3	imaging technique, imaging technique	Paull TT (2000), Choi EH (2017)	2
BLM	2	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
XRCC5	5	PRKDC	12	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology	Jin S (1997), Matheos D (2002), Gell D (1999), Drouet J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Olsen BB (2012), Olsen BB (2012), Sand-Dejmek J (2011), Sartorius CA (2000), Sartorius CA (2000), Drouet J (2006), Drouet J (2006), Sibanda BL (2010), Wan C (2015), Hein MY (2015)	17
TERF2	2	H2AFX	1	two hybrid	Lee OH (2011)	1
POLL	3	PCNA	0	pull down, pull down, pull down	Haracska L (2002), Maga G (2002), Shimazaki N (2002)	3
PML	7	ATRX	7	affinity chromatography technology, imaging technique	Delbarre E (2013), Delbarre E (2013)	2
SUMO2	0	PRKDC	12	pull down	Ouyang J (2009)	1
NTRK1	1	SUPT16H	4	affinity chromatography technology	Emdal KB (2015)	1
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
WRN	6	RAD52	5	pull down, pull down, far western blotting, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003)	8
RAD52	5	SUMO1	0	two hybrid	Shen Z (1996)	1
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
SIRT1	3	NBN	1	affinity chromatography technology, pull down, enzymatic study	Yuan Z (2007), Yuan Z (2007), Yuan Z (2007)	3
PARP1	3	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Pozo FM (2011), Sekimoto T (2010)	6
PRKDC	12	TP53	0	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Kim ST (1999), Goudelock DM (2003), Yavuzer U (1998), Maiti AK (2010), Shieh SY (1997), Chan DW (2000), Kim ST (1999), Sakaguchi K (1998), Borcherds W (2014)	9
WDR48	2	WRN	6	affinity chromatography technology	Sowa ME (2009)	1
SUMO2	0	WRN	6	two hybrid	Hecker CM (2006)	1
SIRT1	3	PARP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Rajamohan SB (2009), Rajamohan SB (2009), Rajamohan SB (2009), Rajamohan SB (2009)	4
SUMO2	0	BLM	2	two hybrid	Hecker CM (2006)	1
PTTG1	0	XRCC6	3	two hybrid, pull down	Romero F (2001), Romero F (2001)	2
NTRK1	1	PML	7	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	ATR	6	affinity chromatography technology, affinity chromatography technology	Zhang N (2009), Zhang N (2009)	2
MDC1	8	CDC5L	2	affinity chromatography technology	Woods NT (2012)	1
ATM	9	FEN1	1	genetic interference	Ward TA (2017)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
NBN	1	CHEK1	2	genetic interference	Pichierri P (2004)	1
NBN	1	PRKDC	12	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
RPA1	0	PARP1	3	affinity chromatography technology	Marechal A (2014)	1
POLB	0	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
XRCC6	3	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
WDR48	2	RAD51	3	pull down	Liang F (2016)	1
RPA2	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Huttlin EL (2015), Huttlin EL (2017)	3
PCNA	0	FEN1	1	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Hasan S (2001), Jonsson ZO (1998), Gary R (1997), Chen U (1996), Chen U (1996), Chen U (1996), Chen U (1996), Chen U (1996), Dianova II (2001), Dianova II (2001), Yu P (2001), Friedrich-Heineken E (2005), Wang SC (2006), Warbrick E (1997), Warbrick E (1997), Bruning JB (2004), Bruning JB (2004), Zhang Z (2012), Pichler G (2012), Takawa M (2012), Wu X (1996), Wu X (1996), Sakurai S (2005), Sharma S (2004), Han J (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	30
MUS81	1	TERF2	2	affinity chromatography technology, affinity chromatography technology	Zeng S (2009), Zeng S (2009)	2
PTTG1	0	WRN	6	genetic interference	Vizeacoumar FJ (2013)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
RAD52	5	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Chen G (1999), Chen G (1999), Otterlei M (2006), Otterlei M (2006), Du Y (2009)	5
SUMO2	0	CHAF1A	1	two hybrid, pull down	Uwada J (2010), Uwada J (2010)	2
POLL	3	RPA2	0	affinity chromatography technology	Boldt K (2016)	1
RPA3	2	NBN	1	affinity chromatography technology	Marechal A (2014)	1
PRKDC	12	CHEK1	2	unspecified method, pull down, genetic interference	Kim ST (1999), Goudelock DM (2003), Shen JP (2017)	3
RPA1	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
PCNA	0	RPA3	2	affinity chromatography technology	Takasaki Y (2001)	1
RPA1	0	CDC5L	2	affinity chromatography technology, pull down, affinity chromatography technology	Marechal A (2014), Marechal A (2014), Lleres D (2010)	3
BLM	2	FEN1	1	affinity chromatography technology, pull down, pull down	Sharma S (2004), Sharma S (2004), Sharma S (2005)	3
CDKN2A	1	TUBA1A	13	pull down	Souza-Rodrigues E (2007)	1
RPA2	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
RPA2	0	DHX9	3	affinity chromatography technology	Marechal A (2014)	1
CREBBP	29	PCNA	0	affinity chromatography technology, pull down, enzymatic study	Cazzalini O (2014), Cazzalini O (2014), Cazzalini O (2014)	3
NBN	1	H2AFX	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Kobayashi J (2002), Kobayashi J (2002), Park JH (2006), Cheng WH (2005), Lukas C (2004), Kobayashi J (2002), Kobayashi J (2002), Pan MR (2011), Kobayashi J (2012)	9
PCNA	0	PRKDC	12	affinity chromatography technology	Ohta S (2002)	1
NBN	1	BLM	2	biochemical	Wang Y (2000)	1
ATM	9	WRN	6	unspecified method	Kim ST (1999)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
FEN1	1	PARP1	3	genetic interference	Ward TA (2017)	1
ATRX	7	RAD51	3	pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, far western blotting, pull down, two hybrid, pull down	Tanaka K (2000), Tanaka K (2000), Sigurdsson S (2002), Mazina OM (2004), Srivastava V (2009), Srivastava V (2009), Srivastava V (2009), Golub EI (1997), Golub EI (1997), Golub EI (1997), Sanchez H (2013)	11
POLL	3	SUPT16H	4	affinity chromatography technology	Boldt K (2016)	1
MDC1	8	WRN	6	unspecified method	Rodriguez M (2003)	1
RPA1	0	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
TINF2	1	WRN	6	affinity chromatography technology	Hein MY (2015)	1
RPA3	2	PRKDC	12	affinity chromatography technology	Marechal A (2014)	1
VCP	6	WRNIP1	3	affinity chromatography technology	Yu CC (2013)	1
XRCC5	5	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Sand-Dejmek J (2011), Sand-Dejmek J (2011)	2
PCNA	0	RAD51	3	affinity chromatography technology, imaging technique	Chen X (2016), Sato K (2016)	2
PARP1	3	POLB	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Huttlin EL (2015), Huttlin EL (2017)	5
NTRK1	1	FEN1	1	affinity chromatography technology	Emdal KB (2015)	1
TUBA1A	13	WEE1	2	genetic interference	Srivas R (2016)	1
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
H2AFX	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Huttlin EL (2017)	5
H2AFX	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Yang X (2010), Yang X (2010), Huttlin EL (2017)	8
XRCC5	5	ATM	9	pull down	Falck J (2005)	1
BLM	2	PARP1	3	affinity chromatography technology	Wang J (2013)	1
ATRX	7	SUPT16H	4	affinity chromatography technology	Leung JW (2013)	1
WRN	6	H2AFX	1	affinity chromatography technology, pull down	Cheng WH (2005), Cheng WH (2005)	2
DHX9	3	XRCC6	3	affinity chromatography technology	Wang Q (2005)	1
RAD54B	3	WRN	6	far western blotting	Otterlei M (2006)	1
CDKN2A	1	PML	7	affinity chromatography technology, affinity chromatography technology, imaging technique	Ivanschitz L (2015), Ivanschitz L (2015), Ivanschitz L (2015)	3
DHX9	3	PRKDC	12	affinity chromatography technology, enzymatic study, biochemical	Mischo HE (2005), Mischo HE (2005), Mischo HE (2005)	3
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
RAD51	3	RPA1	0	pull down, two hybrid	Sugiyama T (2002), Du Y (2009)	2
SUMO2	0	XRCC5	5	pull down	Ouyang J (2009)	1
RPA3	2	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
NTRK1	1	XRCC5	5	affinity chromatography technology	Emdal KB (2015)	1
BLM	2	H2AFX	1	affinity chromatography technology, imaging technique	Sengupta S (2004), Sengupta S (2004)	2
TP53	0	PTTG1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bernal JA (2002), Bernal JA (2002), Bernal JA (2002), Kim HS (2009)	4
PCNA	0	POLK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Ogi T (2010), Ogi T (2010), Jones MJ (2011), Boehm EM (2016)	5
RPA2	0	WRN	6	affinity chromatography technology	Marechal A (2014)	1
PARP1	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Wu T (2013), Huttlin EL (2017)	11
CHEK1	2	WRN	6	genetic interference	Srivas R (2016)	1
TUBA1A	13	CHEK1	2	genetic interference	Srivas R (2016)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
RPA3	2	CDC5L	2	affinity chromatography technology, pull down	Marechal A (2014), Marechal A (2014)	2
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
NTRK1	1	POLR1C	2	affinity chromatography technology	Emdal KB (2015)	1
BLM	2	RPA3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Marechal A (2014)	3
MDC1	8	CHEK2	2	affinity chromatography technology, pull down	Lou Z (2003), Lou Z (2003)	2
CDC5L	2	PARP1	3	affinity chromatography technology	Lleres D (2010)	1
RPA3	2	ATR	6	affinity chromatography technology	Marechal A (2014)	1
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
PARP1	3	PRKDC	12	affinity chromatography technology	Ju BG (2006)	1
PCNA	0	RPA2	0	affinity chromatography technology	Takasaki Y (2001)	1
TERF2	2	WRN	6	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Opresko PL (2002), Opresko PL (2002), Opresko PL (2002), Opresko PL (2002), Opresko PL (2002), Li B (2008)	6
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
ATRX	7	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leung JW (2013), Leung JW (2013), Huh MS (2016)	3
WRN	6	FEN1	1	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, pull down	Sharma S (2004), Brosh RM (2001), Brosh RM (2001), Sharma S (2005), Sharma S (2005), Sharma S (2004), Sharma S (2004), Sharma S (2004)	8
PTTG1	0	RAD51	3	genetic interference	Horlbeck MA (2018)	1
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
MUS81	1	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
WRN	6	WRNIP1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Kawabe Yi (2001), Kawabe Yi (2001), Kawabe Yi (2001), Kawabe Yi (2001)	4
TERF2	2	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Giannone RJ (2010), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Hein MY (2015), Huttlin EL (2017)	7
CHEK1	2	WEE1	2	genetic interference, genetic interference	Srivas R (2016), Srivas R (2016)	2
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
POT1	2	CREBBP	29	affinity chromatography technology	Giannone RJ (2010)	1
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
XRCC5	5	ATR	6	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
NTRK1	1	PARP1	3	affinity chromatography technology	Emdal KB (2015)	1
CHAF1A	1	PRKDC	12	affinity chromatography technology	Hoek M (2011)	1
WRN	6	DHX9	3	pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang S (2007), Friedemann J (2005), Friedemann J (2005), Friedemann J (2005)	4
PCNA	0	WRNIP1	3	pull down	Kanu N (2016)	1
WRN	6	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng WH (2005), Kobayashi J (2010), Kobayashi J (2010)	3
CDC5L	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
POT1	2	PRKDC	12	affinity chromatography technology	Hein MY (2015)	1
PML	7	SIRT1	3	affinity chromatography technology, pull down	Langley E (2002), Langley E (2002)	2
RPA2	0	VCP	6	affinity chromatography technology	Inano S (2017)	1
PRKDC	12	H2AFX	1	enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Park EJ (2003), Mischo HE (2005), Heo K (2008), Heo K (2008), Li A (2010), Kim K (2012)	6
WRN	6	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Zhang N (2005), Zhang N (2005)	2
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
CDKN2A	1	ATR	6	affinity chromatography technology	Rocha S (2005)	1
PCNA	0	POLB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Naryzhny SN (2004), Zhang Z (2014), Zhang Z (2014), Zhang Z (2014)	4
TINF2	1	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, far western blotting, imaging technique, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2013), Her YR (2013), Hein MY (2015), Huttlin EL (2017)	15
KIAA0930	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHAF1A	1	RPA1	0	affinity chromatography technology	Zhu Q (2009)	1
VCP	6	TERF2	2	affinity chromatography technology	Yu CC (2013)	1
CHAF1A	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hoek M (2011), Hoek M (2011), Hoek M (2011), Hoek M (2011)	4
NTRK1	1	WRNIP1	3	affinity chromatography technology	Emdal KB (2015)	1
TERF2	2	NBN	1	affinity chromatography technology, affinity chromatography technology, biochemical	Zhu XD (2000), Zhu XD (2000), Havugimana PC (2012)	3
VCP	6	SUPT16H	4	affinity chromatography technology	Yu CC (2013)	1
RPA1	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
TP53	0	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
CHAF1A	1	XRCC6	3	affinity chromatography technology, pull down, pull down	Hoek M (2011), Hoek M (2011), Hoek M (2011)	3
ATM	9	RPA2	0	enzymatic study	Chan DW (2000)	1
WEE1	2	WRN	6	genetic interference	Srivas R (2016)	1
SUMO2	0	SUPT16H	4	pull down	Ouyang J (2009)	1
CHEK2	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Magni M (2014), Magni M (2014)	2
NTRK1	1	XRCC6	3	affinity chromatography technology	Emdal KB (2015)	1
CHEK1	2	PARP1	3	genetic interference	Shen JP (2017)	1
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
WRN	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar P (2002), Karmakar P (2002), Li B (2000), Cooper MP (2000), Cooper MP (2000), Cooper MP (2000), Li B (2004), Li B (2004), Hein MY (2015), Huttlin EL (2017)	10
PRKDC	12	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Gong Z (2011), Marechal A (2014)	3
POLK	0	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
ATM	9	H2AFX	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsai WB (2008), Tsai WB (2008), Dittmann K (2011), Pan MR (2011), Kim K (2012), Rezaeian AH (2017)	6
SUMO1	0	BLM	2	two hybrid	Hecker CM (2006)	1
POLL	3	WRN	6	affinity chromatography technology	Boldt K (2016)	1
SUMO1	0	WRN	6	two hybrid	Hecker CM (2006)	1
ATR	6	H2AFX	1	imaging technique, enzymatic study	Ray A (2009), Kim K (2012)	2
ATM	9	NBN	1	unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Cariveau MJ (2007), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Wu J (2012), Wei F (2015)	12
SUMO2	0	MUS81	1	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
RPA1	0	RAD52	5	pull down	Sugiyama T (2002)	1
CHEK1	2	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Goudelock DM (2003), Goudelock DM (2003)	2
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
CHEK2	2	BLM	2	genetic interference	Srivas R (2016)	1
WRN	6	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Li B (2004), Li B (2004), Li B (2004)	3
WRN	6	TP53	0	affinity chromatography technology, pull down, pull down	Yang Q (2002), Yang Q (2002), Brosh RM (2001)	3
MDC1	8	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down	Zhang J (2005), Zhang J (2005), Zhang J (2005)	3
SUMO1	0	CHAF1A	1	pull down	Uwada J (2010)	1
SUMO1	0	RAD54B	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
VCP	6	SUMO2	0	affinity chromatography technology	Yu CC (2013)	1
RPA3	2	DHX9	3	affinity chromatography technology	Marechal A (2014)	1
CDC5L	2	DHX9	3	biochemical	Wan C (2015)	1
CREBBP	29	RPA2	0	affinity chromatography technology	Matsuoka S (2007)	1
NTRK1	1	TUBA1A	13	affinity chromatography technology	Emdal KB (2015)	1
RAD51	3	TUBA1A	13	biochemical	Skvarova Kramarzova K (2017)	1
PTTG1	0	CREBBP	29	genetic interference	Vizeacoumar FJ (2013)	1
RAD54B	3	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanaka K (2000), Tanaka K (2000), Tanaka K (2000), Wesoly J (2006)	4
ATM	9	RPA1	0	enzymatic study	Chan DW (2000)	1
ATRX	7	PRKDC	12	affinity chromatography technology	Leung JW (2013)	1
MUS81	1	CHEK2	2	affinity chromatography technology, pull down	Chen XB (2001), Chen XB (2001)	2
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
RAD52	5	TUBA1A	13	affinity chromatography technology	Du Y (2009)	1
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
RAD51	3	TP53	0	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Stuerzbecher HW (1996), Stuerzbecher HW (1996), Buchhop S (1997), Nakai-Murakami C (2007), Yang Q (2004), Rasti M (2015), Rasti M (2015)	10
RPA3	2	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
ATM	9	PARP1	3	pull down	Haince JF (2007)	1
XRCC6	3	POT1	2	affinity chromatography technology	Hein MY (2015)	1
POLB	0	WRN	6	far western blotting	Jiao R (2007)	1
SUPT16H	4	WRN	6	affinity chromatography technology	Boldt K (2016)	1
ATR	6	CHEK2	2	enzymatic study, enzymatic study, genetic interference	Olson E (2006), Matsuoka S (2000), Srivas R (2016)	3
RAD51	3	ATM	9	affinity chromatography technology, affinity chromatography technology	Chen G (1999), Chen G (1999)	2
CDC5L	2	NBN	1	affinity chromatography technology	Lleres D (2010)	1
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
ATM	9	BLM	2	biochemical, pull down, affinity chromatography technology	Wang Y (2000), Beamish H (2002), Beamish H (2002)	3
RAD51	3	BLM	2	affinity chromatography technology, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Wu L (2001), Wu L (2001), Wu L (2001), Yang Q (2004), Srivastava V (2009), Ayguen O (2008), Vizeacoumar FJ (2013)	7
BLM	2	RPA2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Marechal A (2014)	3
CHEK1	2	RAD51	3	affinity chromatography technology, affinity chromatography technology	Sorensen CS (2005), Sorensen CS (2005)	2
TERF2	2	XRCC5	5	affinity chromatography technology, affinity chromatography technology	OConnor MS (2004), Giannone RJ (2010)	2
RPA2	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
CDKN2A	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3
BLM	2	ATR	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Davies SL (2004), Davies SL (2004), Davies SL (2004)	3
SUPT16H	4	RPA3	2	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	DHX9	3	affinity chromatography technology	Emdal KB (2015)	1
ATRX	7	XRCC5	5	affinity chromatography technology	Leung JW (2013)	1