PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
RBCK1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Donley C (2013), Donley C (2013)	6
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
406881	0	ZC3HAV1	4	affinity chromatography technology	Choudhury NR (2014)	1
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
RNF31	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2014), Zhu J (2014)	2
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
TRIM25	5	DDX5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017)	3
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
UBE2D3	1	DDX58	3	enzymatic study	Arimoto K (2008)	1
ERG	1	DDX5	2	affinity chromatography technology	Brenner JC (2011)	1
TRIM25	5	ZC3HAV1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Li MM (2017), Li MM (2017), Zheng X (2017), Zheng X (2017), Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017)	7
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
406881	0	G3BP2	4	affinity chromatography technology	Treiber T (2017)	1
406881	0	TRIM25	5	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Choudhury NR (2014), Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017)	4
ESR1	0	G3BP1	4	affinity chromatography technology	Tarallo R (2011)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
ESR1	0	G3BP2	4	affinity chromatography technology	Tarallo R (2011)	1
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
TRIM25	5	DDX58	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gack MU (2007), Gack MU (2007), Gack MU (2007), Gack MU (2010), Nistal-Villan E (2010), Nistal-Villan E (2010), Inn KS (2011), Inn KS (2011), Maharaj NP (2011), Oshiumi H (2013), Weng L (2014), Xia ZP (2009), Feng M (2012), Gao D (2009), Gao D (2009), Jiang J (2016), Hu Y (2017), Hu Y (2017)	18
TRIM25	5	TRIM25	5	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Reymond A (2001), Gack MU (2009), Zou W (2007), Marblestone JG (2012), Sanchez JG (2014), Sanchez JG (2014), Sanchez JG (2016), Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017), Choudhury NR (2017)	11
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
UBE2D2	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
ESR1	0	KLF5	4	affinity chromatography technology, affinity chromatography technology, pull down	Guo P (2010), Guo P (2010), Guo P (2010)	3
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
G3BP2	4	TRIM25	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Choudhury NR (2017), Choudhury NR (2017)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
DDX58	3	USP15	4	affinity chromatography technology, pull down	Zhang H (2015), Zhang H (2015)	2
ERG	1	TRIM25	5	pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang S (2016), Wang S (2016), Wang S (2016), Wang S (2016), Wang S (2016)	5
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM25	5	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017), Jain S (2016)	3
G3BP2	4	G3BP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Jain S (2016)	3
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
UBE2D1	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
ESR1	0	DDX5	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ambrosino C (2010), Ambrosino C (2010), Fujita T (2003), Mooney SM (2010), Tarallo R (2011), Mooney SM (2010)	6
G3BP1	4	ZC3HAV1	4	affinity chromatography technology	Jain S (2016)	1
TRIM25	5	KLF5	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao KW (2011), Zhao KW (2011), Dong XY (2012), Choudhury NR (2017)	4
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4