Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
EPM2A rs1415744 C chlorpromazine efficacy yes Symptom improvement measured by PANSS score (Positive and Negative Symptom Scale) after 20-40 days of treatment. The CC genotype was associated with an improved response compared to CT, which was also associated with an improved response compared to TT. The CG haplotype of rs1415744 and rs702304 was associated with improvement on the negative symptom scale (p=0.02). Allele C is associated with increased response to chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone or trifluoperazine in people with Schizophrenia as compared to allele T. 27092952 1447987701