PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRPK2	1	PRKAA1	2	enzymatic study	Varjosalo M (2013)	1
PKM	1	EPM2A	1	two hybrid, affinity chromatography technology, two hybrid	Viana R (2015), Viana R (2015), Viana R (2015)	3
EPM2A	1	EPM2A	1	affinity chromatography technology, pull down, two hybrid	Dubey D (2008), Sanchez-Martin P (2013), Viana R (2015)	3
PPP1R3C	3	STBD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STBD1	1	PPP1R3D	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKAA2	1	PRKAB2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Moreno D (2009), Moreno D (2009), Corominas R (2014), Rolland T (2014), Wong KA (2006), Huttlin EL (2017)	8
EPM2A	1	NFU1	0	two hybrid, pull down, affinity chromatography technology	Ganesh S (2003), Ganesh S (2003), Ganesh S (2003)	3
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
PRKAA1	2	EPM2A	1	enzymatic study	Roma-Mateo C (2011)	1
OTUB1	0	EPM2A	1	affinity chromatography technology	Scholz CC (2016)	1
PRKAA2	1	PRKAA1	2	affinity chromatography technology	Behrends C (2010)	1
EPM2A	1	TOPORS	6	two hybrid	Viana R (2015)	1
SRPK2	1	HMGXB4	0	enzymatic study	Lipp JJ (2015)	1
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
PPP1R3C	3	PPP1R3D	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPM2A	1	COX5A	0	two hybrid	Viana R (2015)	1
EPM2A	1	PRKAA2	1	two hybrid, affinity chromatography technology, enzymatic study	Solaz-Fuster MC (2008), Solaz-Fuster MC (2008), Solaz-Fuster MC (2008)	3
EPM2A	1	PSMC3	0	two hybrid	Viana R (2015)	1
STUB1	4	SQSTM1	0	biochemical	Villella VR (2013)	1
EPM2A	1	NHLRC1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology	Lohi H (2005), Lohi H (2005), Lohi H (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Gentry MS (2005), Solaz-Fuster MC (2008), Dubey D (2008), Dubey D (2008), Couarch P (2011), Zeng L (2012), Sanchez-Martin P (2013), Sanchez-Martin P (2013), Zeng L (2012), Mittal S (2015), Mittal S (2015), Sanchez-Martin P (2015)	19
EPM2A	1	EIF2B1	1	two hybrid	Viana R (2015)	1
STUB1	4	NHLRC1	3	affinity chromatography technology, affinity chromatography technology	Rao SN (2010), Sengupta S (2011)	2
UBE2N	1	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
EPM2A	1	HMGXB4	0	two hybrid	Viana R (2015)	1
EPM2A	1	GSK3B	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Lohi H (2005), Lohi H (2005), Lohi H (2005)	3
PPP1R3D	1	EPM2A	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Rubio-Villena C (2013), Rubio-Villena C (2013), Rubio-Villena C (2013)	3
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
SRPK2	1	EPM2A	1	enzymatic study	Lipp JJ (2015)	1
UBE2N	1	EPM2A	1	affinity chromatography technology, affinity chromatography technology	Sanchez-Martin P (2015), Sanchez-Martin P (2015)	2
NHLRC1	3	PPP1R3C	3	enzymatic study, two hybrid	Worby CA (2008), Solaz-Fuster MC (2008)	2
PRKAB2	0	STBD1	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP1R3C	3	EPM2A	1	affinity chromatography technology, two hybrid	Worby CA (2008), Viana R (2015)	2
RPL10	3	EPM2A	1	affinity chromatography technology	Hein MY (2015)	1
STBD1	1	EPM2A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPM2A	1	TDG	0	two hybrid	Viana R (2015)	1
RPL10	3	EIF2B1	1	affinity chromatography technology	Hein MY (2015)	1
STUB1	4	EPM2A	1	affinity chromatography technology	Sengupta S (2011)	1
EPM2A	1	SQSTM1	0	affinity chromatography technology	Sanchez-Martin P (2015)	1
PRKAA1	2	PRKAB2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Al-Hakim AK (2005), Wang J (2011), Varjosalo M (2013), Corominas R (2014), Rolland T (2014), So J (2015), Wan C (2015), Huttlin EL (2017)	10
EPM2A	1	PRKAB2	0	two hybrid, affinity chromatography technology	Solaz-Fuster MC (2008), Huttlin EL (2017)	2
UBE2N	1	NHLRC1	3	affinity chromatography technology	Sanchez-Martin P (2015)	1