PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZC3H12A	1	USP10	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
SMAD3	1	TANK	1	two hybrid	Wang J (2011)	1
TRAF6	0	ZC3H12A	1	affinity chromatography technology	Wang W (2015)	1
USP10	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Niu J (2013), Wang W (2015)	4
KPNA2	0	ZC3H12A	1	two hybrid	Wang J (2011)	1
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
TANK	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang W (2015), Wang W (2015), Wang W (2015)	3
TANK	1	USP10	2	affinity chromatography technology, affinity chromatography technology	Wang W (2015), Wang W (2015)	2
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
TANK	1	ZC3H12A	1	two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Wang W (2015), Wang W (2015), Wang W (2015)	4
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
CYFIP2	7	ZC3H12A	1	two hybrid	Wang J (2011)	1
AIMP2	0	ZC3H12A	1	two hybrid	Vinayagam A (2011)	1
ZC3H12A	1	ZC3H12A	1	affinity chromatography technology, affinity chromatography technology	Lin RJ (2013), Mizgalska D (2009)	2
CEBPB	2	ZC3H12A	1	unspecified method, affinity chromatography technology	Lipert B (2017), Lipert B (2017)	2
EP300	36	KPNA2	0	enzymatic study	Bannister AJ (2000)	1
CEBPB	2	EP300	36	genetic interference, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology	Mink S (1997), Mink S (1997), Mink S (1997), Mink S (1997), Mink S (1997), Deng WG (2004), Deng WG (2004), Deng WG (2003)	8
HIF1A	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016), Nowicka AM (2016)	4
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
SMAD3	1	ZC3H12A	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRAF6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Sun H (2013), Sun H (2013), Sun H (2013), Rezaeian AH (2017), Rezaeian AH (2017)	5
ZC3H12A	1	UBC	7	enzymatic study, pull down, affinity chromatography technology	Liang J (2010), Niu J (2013), Liang J (2010)	3
AIMP2	0	TRAF6	0	affinity chromatography technology	Kim DG (2016)	1
KPNA2	0	TANK	1	two hybrid	Wang J (2011)	1
BTRC	1	ZC3H12A	1	two hybrid, two hybrid	Vinayagam A (2011), Wang J (2011)	2
SMAD3	1	CEBPB	2	pull down	Choy L (2003)	1
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
XPO1	8	ZC3H12A	1	affinity chromatography technology	Kirli K (2015)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
HIF1A	1	SMAD3	1	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2002)	5
EP300	36	ZC3H12A	1	two hybrid	Wang J (2011)	1
IKBKG	0	TANK	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chariot A (2002), Chariot A (2002), Chariot A (2002), Zhang W (2010), Zhang W (2010), Zhao T (2007), Wang J (2011), Wang W (2015), Huttlin EL (2017)	9
AIMP2	0	TANK	1	two hybrid	Wang J (2011)	1
IRAK2	3	ZC3H12A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZC3H12A	1	ZC3H12D	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Huang S (2015), Huang S (2015), Huang S (2015), Huang S (2015), Huang S (2015)	5
AHSP	0	ZC3H12A	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
IKBKG	0	BTRC	1	affinity chromatography technology	Orel L (2010)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
ZC3H12A	1	IL1B	0	affinity chromatography technology	Mizgalska D (2009)	1
ZC3H12A	1	P4HA3	3	two hybrid	Rolland T (2014)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
ZC3H12A	1	HIF1A	1	enzymatic study	Roy A (2013)	1
TRAF6	0	USP10	2	affinity chromatography technology	Wang W (2015)	1
EP300	36	HIF1A	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Lando D (2002), Freedman SJ (2002), Lewis MD (2004), Matt T (2004), Sang N (2002), Luo W (2010), Freedman SJ (2003), Bodily JM (2011), Lee YM (2009), Lee YM (2009), Lee YM (2009), Kung AL (2004), Kung AL (2004), Kung AL (2004), Land SC (2007), Zhang Y (2010), Zhang Y (2010), Fath DM (2006), Fath DM (2006), Lee SJ (2013), Wang D (2014), Kaluz S (2006), Kaluz S (2006), Kaluz S (2006), Shin DH (2008), Shin DH (2008), Wang Y (2012), Huang C (2009), Hewitson KS (2002), Cook KM (2009), Cook KM (2009), Hubbi ME (2012), Kim SY (2014), Sang N (2003), Sang N (2003), Sang N (2003), Yasinska IM (2003), Na YR (2013), Na YR (2013), Mendonca DB (2011), Arany Z (1996), Arany Z (1996), Chen R (2012), Li SH (2008), Galbraith MD (2013), Chen Z (2014), Li Q (2012), Geng H (2012), Geng H (2012), Kato H (2004), Lim JH (2010), Kyle HF (2015), Kyle HF (2015), Rath S (2016), Kimura M (2008), Dubey R (2013)	56
IKBKG	0	ZC3H12A	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Niu J (2013), Niu J (2013), Wang W (2015)	3