Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CASP1	834	METHOHEXITAL	CHEMBL7413	inhibitor	GuideToPharmacologyInteractions
CASP1	834	ICOSAPENT	CHEMBL460026		DrugBank
CASP1	834	EMRICASAN	CHEMBL197672	inhibitor	ChemblInteractions, DrugBank
CASP1	834	BELNACASAN	CHEMBL2107819		TdgClinicalTrial, DrugBank
CASP1	834	NIVOCASAN	CHEMBL2105721	inhibitor	ChemblInteractions
CASP1	834	PRALNACASAN	CHEMBL437526	inhibitor	GuideToPharmacologyInteractions, DrugBank	17845807

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CASP1	rs557905	T	peginterferon alfa-2b	efficacy	yes	The significance of this association did not reach genome-wide significance. This genotype is associated with sustained virological response (SVR). SVR is defined as negative OCR test for Hepatitis C 6 months after the cessation of therapy. The authors do not indicate polarity of the association. However, decreased polarity can be inferred from Table 2 in the paper.	Allele T is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to allele C.	19749758	1444705674
CASP1	rs568910	A	peginterferon alfa-2b	efficacy	yes	The significance of this association did not reach genome-wide significance. This genotype is associated with sustained virological response (SVR). SVR is defined as negative OCR test for Hepatitis C 6 months after the cessation of therapy. The authors do not indicate polarity of the association. However, decreased polarity can be inferred from Table 2 in the paper.	Allele A is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to allele C.	19749758	1444705683