PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP1	1	PI4KB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOD1	3	NOD2	1	affinity chromatography technology, affinity chromatography technology	Travassos LH (2010), Travassos LH (2010)	2
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
KEAP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Ichikawa T (2009), Lau A (2010), Li Y (2012), Niture SK (2013), Kaspar JW (2012), Kaspar JW (2012), Zhang DD (2004), Lo SC (2006)	9
CASP1	1	IL18	0	enzymatic study	Kumar S (2002)	1
CASP1	1	BCAP31	0	enzymatic study	Ng FW (1997)	1
CASP1	1	NOD2	1	affinity chromatography technology	Damiano JS (2004)	1
CASP1	1	IL1B	0	enzymatic study, enzymatic study	Gu Y (1995), Eldridge MJG (2017)	2
IFI16	1	CASP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
CASP1	1	TRAF2	1	affinity chromatography technology	Labbe K (2011)	1
NLRC4	2	XK	0	affinity chromatography technology	Damiano JS (2004)	1
BCAP31	0	CASP8	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical	Ng FW (1997), Ng FW (1997), Ng FW (1997), Iwasawa R (2011), Chandra D (2004), Breckenridge DG (2002), Breckenridge DG (2002)	7
NOD1	3	CASP1	1	affinity chromatography technology	Inohara N (1999)	1
EGFR	5	CEBPB	2	affinity chromatography technology	Harmon AW (2002)	1
CASP1	1	GAB1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP14	2	CASP10	1	affinity chromatography technology	Hu S (1998)	1
CASP14	2	CASP8	1	affinity chromatography technology	Hu S (1998)	1
CASP1	1	PARP1	3	enzymatic study	Gu Y (1995)	1
NLRC4	2	NOD1	3	affinity chromatography technology	Damiano JS (2004)	1
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
CASP1	1	CASP1	1	affinity chromatography technology	Lee SH (2001)	1
CARD16	0	CASP1	1	affinity chromatography technology, affinity chromatography technology	Lee SH (2001), Lee SH (2001)	2
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
CASP1	1	CUL3	17	affinity chromatography technology	Garstkiewicz M (2017)	1
CASP14	2	CASP1	1	affinity chromatography technology	Hu S (1998)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
EGFR	5	VAC14	5	affinity chromatography technology	Foerster S (2013)	1
KEAP1	0	BRCA1	7	affinity chromatography technology	Ma J (2012)	1
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
CASP1	1	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SERPINB9	0	CASP1	1	pull down	Annand RR (1999)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
CASP1	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
CARD16	0	RIPK2	0	affinity chromatography technology	Lee SH (2001)	1
CASP1	1	VAC14	5	two hybrid	Rolland T (2014)	1
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
BRCA1	7	KIF11	5	affinity chromatography technology	Ertych N (2016)	1
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
CASP10	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
NLRC4	2	PYCARD	1	two hybrid	Geddes BJ (2001)	1
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
CASP1	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001)	2
KEAP1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Huo L (2015), Huo L (2015), Huo L (2015)	3
NOD1	3	RIPK2	0	affinity chromatography technology, affinity chromatography technology, pull down	Inohara N (1999), Hirata Y (2006), Ver Heul AM (2013)	3
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
PYCARD	1	CASP1	1	affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015)	2
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
CASP1	1	PLCL2	4	affinity chromatography technology	Huttlin EL (2017)	1
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
CASP1	1	NFE2L2	1	affinity chromatography technology	Garstkiewicz M (2017)	1
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
SERPINB9	0	CASP10	1	affinity chromatography technology	Kummer JA (2007)	1
CASP1	1	FMN2	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCAP31	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Ng FW (1997), Ng FW (1997), Mund T (2003)	3
BRCA1	7	CEBPB	2	affinity chromatography technology	Hill SJ (2014)	1
NLRC4	2	NOD2	1	affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001)	2
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CASP1	1	RBX1	2	affinity chromatography technology	Garstkiewicz M (2017)	1
CASP1	1	IL37	0	enzymatic study	Kumar S (2002)	1
BRCA1	7	NFE2L2	1	affinity chromatography technology, affinity chromatography technology	Gorrini C (2013), Gorrini C (2013)	2
CASP1	1	KIF3A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SERPINB9	0	CASP8	1	affinity chromatography technology	Kummer JA (2007)	1
CASP8	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
BIRC3	1	CASP1	1	affinity chromatography technology, affinity chromatography technology	Labbe K (2011), Labbe K (2011)	2
CASP8	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Kumar Y (2010), Raghawan AK (2017)	2
CEBPB	2	CASP1	1	affinity chromatography technology, affinity chromatography technology	Buck M (2001), Buck M (2001)	2
EGFR	5	PARP1	3	affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017)	2
KEAP1	0	NFE2L2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cullinan SB (2003), Shibata T (2008), Wang XJ (2008), Nioi P (2007), Tanigawa S (2007), Tanigawa S (2007), Hong F (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2003), McMahon M (2006), Ichikawa T (2009), Niture SK (2009), Niture SK (2009), Wu JH (2010), Wong DP (2010), Wong DP (2010), Yu M (2011), Lau A (2010), Lau A (2010), Kay HY (2010), Sun Z (2011), Sun Z (2011), Li X (2004), Li X (2004), Lo SC (2008), Plafker KS (2010), Plafker KS (2010), Yao JW (2012), Li Y (2012), Lo SC (2006), Lo SC (2006), Lo SC (2006), Eggler AL (2005), Zipper LM (2002), Sekhar KR (2002), Seng S (2009), Hast BE (2013), Hoerer S (2013), Baba K (2013), Wang J (2011), Ichimura Y (2013), Baird L (2013), Baird L (2013), Gorrini C (2013), Schaap M (2013), Jiang ZY (2014), Hast BE (2014), Hast BE (2014), Hast BE (2014), Qin S (2014), Buommino E (2012), Kaspar JW (2012), Kaspar JW (2012), Camp ND (2012), Zhang DD (2004), Furukawa M (2005), Khan H (2015), Huo L (2015), Foygel K (2015), Liu K (2015), Lo SC (2006), Kim WD (2012), Kim WD (2012), Kim WD (2012), Zhang Y (2016), Zhang Y (2016), Wu G (2017), Villeneuve NF (2013), Ma J (2012), Ma J (2012), Ma J (2012), Ge W (2017), Ge W (2017), Yoshizaki Y (2017), Yoshizaki Y (2017), Quinti L (2017), Wang Q (2017), Ha Kim K (2017), Yang C (2016), Mulvaney KM (2016), Lu K (2017)	82
PYCARD	1	BRCA1	7	affinity chromatography technology, imaging technique, affinity chromatography technology	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
CASP1	1	TIRAP	1	enzymatic study	Ulrichts P (2010)	1
CEBPB	2	CASP8	1	affinity chromatography technology, affinity chromatography technology	Buck M (2001), Buck M (2001)	2
BRCA1	7	CASP1	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015), Dutta D (2015)	3
CASP1	1	EGFR	5	enzymatic study	Bae SS (2001)	1
BCL2L1	0	CASP1	1	affinity chromatography technology	Chinnaiyan AM (1997)	1
CASP1	1	KEAP1	0	affinity chromatography technology	Garstkiewicz M (2017)	1
BRCA1	7	IFI16	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Aglipay JA (2003), Dutta D (2015), Dutta D (2015), Dutta D (2015)	4
EGFR	5	GAB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, enzymatic study, affinity chromatography technology	Kameda H (2001), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Lehr S (1999), Mueller KL (2012)	6
IFI16	1	PYCARD	1	imaging technique, affinity chromatography technology	Dutta D (2015), Dutta D (2015)	2
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
CASP1	1	XK	0	affinity chromatography technology	Damiano JS (2004)	1
CASP1	1	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
KIF11	5	ARID4B	1	affinity chromatography technology	Hein MY (2015)	1
CASP1	1	KIF11	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC3	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
CASP1	1	IL33	2	enzymatic study	Schmitz J (2005)	1
CASP8	1	PARP1	3	enzymatic study	Betin VM (2009)	1