PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAF4	4	CDC16	2	biochemical	Wan C (2015)	1
TAF3	0	TAF4	4	biochemical	Havugimana PC (2012)	1
TAF8	2	TAF7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	4
TAF4	4	TAF6	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
NPM1	0	HIST3H3	0	far western blotting	Okuwaki M (2001)	1
TBP	0	TAF7L	1	affinity chromatography technology	Pointud JC (2003)	1
TAF6	4	TAF12	0	two hybrid	Bando M (1997)	1
HIST3H3	0	TAF6	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Vermeulen M (2007), Varier RA (2010), Vermeulen M (2010)	3
HIST3H3	0	TAF8	2	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF8	2	TAF5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Demeny MA (2007), Demeny MA (2007), Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017)	5
TAF5	1	TAF12	0	affinity chromatography technology	Tao Y (1997)	1
TAF8	2	TAF12	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST3H3	0	TBP	0	unspecified method	Vermeulen M (2010)	1
TAF10	0	TAF1	9	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Gupta K (2017)	2
TAF4	4	TAF12	0	far western blotting, x-ray crystallography, pull down	Guermah M (2001), Werten S (2002), Shao H (2005)	3
TAF8	2	KPNA2	0	pull down	Soutoglou E (2005)	1
HIST3H3	0	TAF7	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF11	0	TAF3	0	affinity chromatography technology	Gupta K (2017)	1
TAF3	0	KAT2A	1	affinity chromatography technology	Gangloff YG (2001)	1
TAF4	4	TAF10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Brand M (2001), Jeronimo C (2007), Cavusoglu N (2003), Havugimana PC (2012), Wan C (2015)	5
TBP	0	TAF3	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Knuesel MT (2009), Gangloff YG (2001), Gangloff YG (2001), Liu Z (2011)	4
TAF11	0	TAF6	4	affinity chromatography technology	Gupta K (2017)	1
TAF3	0	TAF12	0	affinity chromatography technology	Gangloff YG (2001)	1
TAF7L	1	TAF10	0	affinity chromatography technology	Huttlin EL (2017)	1
TAF10	0	TAF6	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical	Kouskouti A (2004), Demeny MA (2007), Cavusoglu N (2003), Havugimana PC (2012), Wan C (2015)	5
TAF5	1	TAF7	0	affinity chromatography technology, biochemical, affinity chromatography technology	Tao Y (1997), Havugimana PC (2012), Gupta K (2017)	3
CDC16	2	NAP1L4	3	biochemical	Wan C (2015)	1
KAT2A	1	HIST3H3	0	enzymatic study, affinity chromatography technology, unspecified method	Yang XJ (1996), Vermeulen M (2010), Vermeulen M (2010)	3
TAF10	0	SAP130	2	biochemical, biochemical	Demeny MA (2007), Havugimana PC (2012)	2
TAF3	0	KPNA2	0	pull down	Soutoglou E (2005)	1
TAF1	9	TAF4	4	pull down, biochemical, biochemical, affinity chromatography technology	Guermah M (2001), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	4
TBP	0	TAF12	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Knuesel MT (2009), Liu X (2008), Denissov S (2007), Wieczorek E (1998), Hoffmann A (1996), Hoffmann A (1996)	6
MED26	2	TAF7	0	affinity chromatography technology	Takahashi H (2011)	1
TBP	0	TAF4	4	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Liu X (2008), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Ogryzko VV (1998)	10
MED26	2	TAF8	2	affinity chromatography technology	Takahashi H (2011)	1
TAF4	4	NAP1L4	3	biochemical	Wan C (2015)	1
MED26	2	TAF3	0	affinity chromatography technology	Takahashi H (2011)	1
TAF10	0	KPNA2	0	pull down, affinity chromatography technology	Soutoglou E (2005), Soutoglou E (2005)	2
CDC23	3	TAF4	4	biochemical	Wan C (2015)	1
TAF3	0	HIST2H4A	0	affinity chromatography technology	Vermeulen M (2007)	1
NPM1	0	TAF3	0	affinity chromatography technology	Chen R (2013)	1
TAF13	2	TAF6	4	affinity chromatography technology	Jeronimo C (2007)	1
TAF3	0	SAP130	2	affinity chromatography technology	Gangloff YG (2001)	1
TAF4	4	TAF8	2	far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2001), Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017)	4
TAF11	0	TAF10	0	affinity chromatography technology	Gupta K (2017)	1
CDC16	2	CDC23	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
HIST3H3	0	TAF12	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF11	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
TAF1	9	TAF7	0	two hybrid, pull down, biochemical, affinity chromatography technology	Gegonne A (2001), Gegonne A (2001), Havugimana PC (2012), Gupta K (2017)	4
TAF5	1	CDC16	2	biochemical	Wan C (2015)	1
HIST3H3	0	TAF11	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF7L	1	TAF5	1	affinity chromatography technology	Huttlin EL (2017)	1
TAF1	9	TAF3	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Gupta K (2017)	3
TAF7L	1	TAF3	0	affinity chromatography technology	Huttlin EL (2017)	1
TAF11	0	TAF13	2	pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology	Mengus G (1995), Birck C (1998), Gupta K (2017), Gupta K (2017), Gupta K (2017)	5
TAF5	1	TAF11	0	affinity chromatography technology, affinity chromatography technology	Tao Y (1997), Gupta K (2017)	2
TAF7L	1	TAF4	4	affinity chromatography technology	Huttlin EL (2017)	1
TAF10	0	KPNB1	3	pull down, affinity chromatography technology	Soutoglou E (2005), Soutoglou E (2005)	2
CTCF	15	KPNA2	0	affinity chromatography technology	Yusufzai TM (2004)	1
TAF11	0	TAF4	4	affinity chromatography technology	Gupta K (2017)	1
HIST3H3	0	TAF3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Vermeulen M (2007), Vermeulen M (2007), Varier RA (2010), Varier RA (2010), Vermeulen M (2010)	5
TAF7L	1	TAF1	9	two hybrid, affinity chromatography technology	Pointud JC (2003), Huttlin EL (2017)	2
TAF6	4	TAF7	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Gupta K (2017)	2
TBP	0	TAF11	0	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology	Bellorini M (1997), Mengus G (1995), May M (1996), Knuesel MT (2009), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Brand M (1999), Gupta K (2017), Gupta K (2017)	10
TAF11	0	TAF7	0	affinity chromatography technology, affinity chromatography technology	Gupta K (2017), Gupta K (2017)	2
TAF8	2	TAF1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017), Gupta K (2017)	4
TAF3	0	TAF6	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TAF3	0	CDC23	3	biochemical	Wan C (2015)	1
TAF8	2	KPNB1	3	pull down	Soutoglou E (2005)	1
TAF3	0	TAF7	0	affinity chromatography technology, affinity chromatography technology	Gangloff YG (2001), Gupta K (2017)	2
MED26	2	TAF5	1	affinity chromatography technology	Takahashi H (2011)	1
CDC23	3	NAP1L4	3	biochemical	Wan C (2015)	1
KHDRBS2	1	TAF3	0	affinity chromatography technology	Jeronimo C (2007)	1
TAF7	0	TAF13	2	affinity chromatography technology	Gupta K (2017)	1
KPNB1	3	KPNA2	0	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nagoshi E (2001), Koehler M (1999), Kutay U (1997), Hein MY (2015), Huttlin EL (2017)	5
TAF13	2	TAF1	9	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Gupta K (2017)	2
TAF3	0	TBPL2	1	affinity chromatography technology, biochemical	Deato MD (2007), Deato MD (2007)	2
HIST3H3	0	TAF5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Vermeulen M (2007), Varier RA (2010), Vermeulen M (2010)	3
TAF13	2	TAF5	1	affinity chromatography technology, biochemical	Jeronimo C (2007), Havugimana PC (2012)	2
NAP1L4	3	HIST2H4A	0	pull down	Rodriguez P (1997)	1
ANAPC10	0	TAF3	0	biochemical	Wan C (2015)	1
TBP	0	TAF5	1	affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Bellorini M (1997), Tao Y (1997), Ruppert S (1993), Knuesel MT (2009), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Soutoglou E (2005), Ogryzko VV (1998), Le Douarin B (1995), Wan C (2015)	15
TAF13	2	TAF10	0	two hybrid, pull down, biochemical	Mengus G (1995), Mengus G (1995), Havugimana PC (2012)	3
TAF8	2	TAF13	2	pull down, affinity chromatography technology	Demeny MA (2007), Huttlin EL (2017)	2
TAF3	0	CTCF	15	affinity chromatography technology	Liu Z (2011)	1
TAF13	2	TAF7L	1	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
TAF10	0	TAF5	1	biochemical, biochemical, affinity chromatography technology, biochemical	Demeny MA (2007), Wieczorek E (1998), Cavusoglu N (2003), Havugimana PC (2012)	4
KAT2A	1	HIST2H4A	0	enzymatic study	Cereseto A (2005)	1
TAF4	4	TAF5	1	affinity chromatography technology, biochemical	Brand M (2001), Wan C (2015)	2
MED26	2	TAF13	2	affinity chromatography technology	Takahashi H (2011)	1
ANAPC10	0	CDC16	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Kurasawa Y (1999), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	4
TAF3	0	KPNB1	3	pull down	Soutoglou E (2005)	1
TAF7	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
HIST3H3	0	TAF1	9	affinity chromatography technology, affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2007), Vermeulen M (2010)	3
TAF8	2	TAF3	0	affinity chromatography technology	Huttlin EL (2017)	1
TBP	0	TAF6	4	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Nakamura T (2002), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Soutoglou E (2005), Ogryzko VV (1998)	14
MED26	2	TAF11	0	affinity chromatography technology	Takahashi H (2011)	1
CDC16	2	TAF3	0	biochemical	Wan C (2015)	1
TAF10	0	TAF3	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Jeronimo C (2007), Gangloff YG (2001), Soutoglou E (2005), Soutoglou E (2005)	4
TBP	0	TAF10	0	biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Kouskouti A (2004), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Wieczorek E (1998), Kamileri I (2012), Havugimana PC (2012), Le Douarin B (1995)	11
TAF6	4	TAF5	1	pull down, affinity chromatography technology, biochemical, biochemical	Hsieh YJ (1999), Tao Y (1997), Havugimana PC (2012), Wan C (2015)	4
KAT2A	1	TAF6	4	affinity chromatography technology	Kim J (2010)	1
TAF5	1	ANAPC10	0	biochemical	Wan C (2015)	1
TAF10	0	KAT2A	1	affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Demeny MA (2007), Cavusoglu N (2003)	3
CTCF	15	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yusufzai TM (2004), Yusufzai TM (2004), Yusufzai TM (2004), Witcher M (2009)	4
MZT1	1	TAF3	0	affinity chromatography technology	Hein MY (2015)	1
TAF7L	1	TAF6	4	affinity chromatography technology	Huttlin EL (2017)	1
TAF7L	1	TAF12	0	affinity chromatography technology	Huttlin EL (2017)	1
TAF10	0	TAF7	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Jeronimo C (2007), Kouskouti A (2004), Wieczorek E (1998), Havugimana PC (2012), Gupta K (2017)	5
TAF4	4	TAF7	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Gupta K (2017)	3
TAF10	0	TAF8	2	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Demeny MA (2007), Demeny MA (2007), Demeny MA (2007), Guermah M (2003), Guermah M (2003), Soutoglou E (2005), Soutoglou E (2005), Huttlin EL (2015), Huttlin EL (2017)	9
TAF8	2	TAF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guermah M (2003), Huttlin EL (2017), Gupta K (2017)	3
NAP1L4	3	HIST3H3	0	pull down	Rodriguez P (1997)	1
TBP	0	TAF7	0	affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Wieczorek E (1998), Dantonel JC (1997), Dantonel JC (1997), Kamileri I (2012), Gupta K (2017)	8
TAF3	0	TAF13	2	affinity chromatography technology	Gangloff YG (2001)	1
ANAPC10	0	CDC23	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
HIST3H3	0	TAF13	2	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF7L	1	TAF11	0	affinity chromatography technology	Huttlin EL (2017)	1
TAF3	0	TAF5	1	biochemical	Havugimana PC (2012)	1
MED26	2	TAF4	4	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
HIST3H3	0	TAF4	4	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF4	4	KAT2A	1	affinity chromatography technology	Brand M (2001)	1
MED26	2	TBP	0	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
TBP	0	TAF8	2	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Liu X (2008), Demeny MA (2007), Demeny MA (2007), Guermah M (2003), Bhatnagar A (2013)	5
TAF5	1	TAF1	9	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tao Y (1997), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	4
KPNB1	3	TAF11	0	affinity chromatography technology	Hein MY (2015)	1
TAF1	9	TBP	0	pull down, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Siegert JL (1999), Bellorini M (1997), Ruppert S (1993), OBrien T (1998), Knuesel MT (2009), Hilton TL (2005), Liu X (2008), Demeny MA (2007), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Klemm RD (1995), Dallas PB (1997), Ogryzko VV (1998), Gupta K (2017)	15
TAF6	4	TAF1	9	pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hisatake K (1995), Nakamura T (2002), Havugimana PC (2012), Wan C (2015), Gupta K (2017)	5
MED26	2	TAF6	4	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
TAF10	0	TAF12	0	affinity chromatography technology	Cavusoglu N (2003)	1
NAP1L4	3	NPM1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
TAF11	0	TAF1	9	affinity chromatography technology, affinity chromatography technology	Gupta K (2017), Gupta K (2017)	2
ANAPC10	0	NAP1L4	3	biochemical	Wan C (2015)	1
TAF7L	1	TAF8	2	affinity chromatography technology	Huttlin EL (2017)	1
MED26	2	TAF1	9	affinity chromatography technology, affinity chromatography technology	Takahashi H (2011), Takahashi H (2011)	2
TBPL2	1	KPNA2	0	two hybrid, pull down, pull down	Nishinaka Y (2004), Nishinaka Y (2004), Nishinaka Y (2004)	3
TAF8	2	TAF6	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Demeny MA (2007), Demeny MA (2007), Guermah M (2003), Huttlin EL (2015), Huttlin EL (2017)	5
MED26	2	TAF10	0	affinity chromatography technology	Takahashi H (2011)	1
TAF3	0	NAP1L4	3	biochemical	Wan C (2015)	1
HIST3H3	0	TAF10	0	affinity chromatography technology, unspecified method	Vermeulen M (2007), Vermeulen M (2010)	2
TAF13	2	TBP	0	two hybrid, pull down, pull down, biochemical, pull down	Mengus G (1995), Mengus G (1995), Knuesel MT (2009), Havugimana PC (2012), Gupta K (2017)	5
TAF13	2	TAF4	4	affinity chromatography technology, biochemical	Jeronimo C (2007), Havugimana PC (2012)	2