Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
DOT1L	84444	CHEMBL3087499	CHEMBL3087499	inhibitor	GuideToPharmacologyInteractions
DOT1L	84444	CHEMBL2349526	CHEMBL2349526	inhibitor	GuideToPharmacologyInteractions
DOT1L	84444	CHEMBL3087498	CHEMBL3087498	inhibitor	GuideToPharmacologyInteractions
DOT1L	84444	CHEMBL2169919	CHEMBL2169919	inhibitor	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
DOT1L	rs2269879	CT + TT	hydrochlorothiazide	efficacy	yes	In the PEAR cohort, in Whites: 5.5 mmHg greater mean systolic bp response(p = 0.0002 uncorrected) and a 3.5 mmHg greater mean diastolic bp response (p = 0.0016 uncorrected). [stat_test:linear regression]. More than 90% of participants were receiving 25 mg/day HCTZ (the rest received 12.5 mg/day). This did not replicate significantly in a second cohort(GERA) and authors concluded that there could possibly be an association between this SNP and blood pressure response to HCTZ in Caucasians, but that it requires further investigation. Significance for this segment of the study was set at p < 0.01 for a partially corrected p, and in Whites, this level was met when a partial correction for multiple testing was done. But for a compound, corrected p predetermined by the authors to be the significance point for both segments of the study, the significance test failed.	Genotypes CT + TT are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype CC.	22440088	981238979
DOT1L	rs2269879	CT + TT	hydrochlorothiazide	efficacy	no	More than 90% of participants were receiving 25 mg/day HCTZ (the rest received 12.5 mg/day). The direction of association in GERA Whites was the same as in PEAR Whites, but in GERA, the association was not significant. [stat_test:linear regression].	Genotypes CT + TT are not associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype CC.	22440088	981239001