PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	DOT1L	7	genetic interference	Xie L (2013)	1
NPM1	0	HIST1H1C	2	affinity chromatography technology, affinity chromatography technology	Park G (2010), Hein MY (2015)	2
NPM1	0	HIST3H3	0	far western blotting	Okuwaki M (2001)	1
BAG6	2	HIST2H3C	0	affinity chromatography technology, affinity chromatography technology	Wakeman TP (2012), Wakeman TP (2012)	2
NPM1	0	GNL3	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	EBNA1BP2	0	affinity chromatography technology	Fogeron ML (2013)	1
MLLT6	2	MLLT10	3	affinity chromatography technology	Huttlin EL (2017)	1
NPM1	0	HIST1H1A	0	affinity chromatography technology	Park G (2010)	1
BAG6	2	DOT1L	7	affinity chromatography technology, affinity chromatography technology	Wakeman TP (2012), Wakeman TP (2012)	2
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
DOT1L	7	HIST1H1C	2	affinity chromatography technology	Park G (2010)	1
HNRNPU	12	DDX21	0	affinity chromatography technology	Hein MY (2015)	1
EBNA1BP2	0	DDX21	0	affinity chromatography technology	Huttlin EL (2015)	1
NPM1	0	DDX21	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Park G (2010), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	4
NPM1	0	H1FX	0	affinity chromatography technology, affinity chromatography technology	Park G (2010), Hein MY (2015)	2
DOT1L	7	HIST2H3C	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wu L (2011), Wakeman TP (2012), Wakeman TP (2012)	3
YBX3	0	HNRNPU	12	biochemical	Kristensen AR (2012)	1
DOT1L	7	MLLT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), He N (2011), He N (2011)	7
NPM1	0	HNRNPM	1	affinity chromatography technology	Park G (2010)	1
SIRT1	3	DOT1L	7	affinity chromatography technology, affinity chromatography technology	Zhang D (2009), Park G (2010)	2
MLLT1	1	HIST3H3	0	pull down	Zeisig DT (2005)	1
AFF1	1	DOT1L	7	affinity chromatography technology, affinity chromatography technology	Benedikt A (2011), Benedikt A (2011)	2
MLLT1	1	AFF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller D (2009), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Benedikt A (2011), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Lu H (2014), Ui A (2015)	12
NPM1	0	GRWD1	3	affinity chromatography technology	Chen R (2013)	1
NIN	4	TP53	0	bioid	Gupta GD (2015)	1
HIST1H2AA	1	HIST1H2BB	3	biochemical	Havugimana PC (2012)	1
YEATS4	0	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	MAPK7	1	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	PARP16	1	affinity chromatography technology	Hein MY (2015)	1
MLLT10	3	DOT1L	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada Y (2005), Park G (2010), Hein MY (2015)	3
SYNCRIP	6	DDX21	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM45	1	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	STAT1	1	affinity chromatography technology, pull down	Shah S (2011), Shah S (2011)	2
HNRNPM	1	SYNCRIP	6	biochemical	Havugimana PC (2012)	1
MLLT3	0	AFF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Benedikt A (2011), Biswas D (2011), Takahashi H (2011)	5
KMT2A	58	AFF1	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Yokoyama A (2010), Benedikt A (2011), Benedikt A (2011), Benedikt A (2011)	4
YEATS4	0	MLLT6	2	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	BRINP1	5	affinity chromatography technology	Hein MY (2015)	1
MLLT1	1	MLLT10	3	affinity chromatography technology, two hybrid	Park G (2010), Zeisig DT (2005)	2
TP53	0	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
DOT1L	7	DDX21	0	affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010)	2
DOT1L	7	H1FX	0	affinity chromatography technology	Park G (2010)	1
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
EBNA1BP2	0	GNL3	3	biochemical	Havugimana PC (2012)	1
MLLT6	2	MLLT3	0	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
BRINP1	5	TP53	0	affinity chromatography technology	Qin B (2015)	1
DOT1L	7	GRWD1	3	affinity chromatography technology	Park G (2010)	1
LIN28A	1	DOT1L	7	genetic interference	Onder TT (2012)	1
DOT1L	7	HNRNPM	1	affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010)	2
HNRNPU	12	SYNCRIP	6	two hybrid, two hybrid, biochemical, biochemical, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
DOT1L	7	MLLT3	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang W (2006), Zhang W (2006), Zhang W (2006), Zhang W (2006), Zhang W (2007), Park G (2010), Park G (2010), Monroe SC (2011), Biswas D (2011), He N (2011), Hein MY (2015), Li Y (2014)	12
YEATS4	0	HIST3H3	0	affinity chromatography technology	Wang Y (2018)	1
DOT1L	7	HIST3H3	0	enzymatic study	Whitcomb SJ (2012)	1
DOT1L	7	GNL3	3	affinity chromatography technology	Park G (2010)	1
MLLT1	1	SIRT1	3	affinity chromatography technology	Park G (2010)	1
MLLT10	3	YEATS4	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Debernardi S (2002), Debernardi S (2002), Debernardi S (2002), Debernardi S (2002)	4
AFF1	1	HIST3H3	0	enzymatic study	Benedikt A (2011)	1
NANOG	0	ALYREF	0	affinity chromatography technology	Oliviero G (2015)	1
IBTK	3	DDX21	0	affinity chromatography technology	Hein MY (2015)	1
CKAP5	2	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
HIST2H3C	0	STAT1	1	affinity chromatography technology	Noon-Song EN (2011)	1
SYNCRIP	6	EBNA1BP2	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPU	12	EBNA1BP2	0	affinity chromatography technology	Hein MY (2015)	1
KMT2A	58	DOT1L	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Monroe SC (2011), Tan J (2011), Tan J (2011)	3
HNRNPM	1	ALYREF	0	biochemical	Havugimana PC (2012)	1
SIRT1	3	BRINP1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Zhao W (2008), Chini CC (2010), Close P (2012), Armour SM (2013), Kim JE (2008), Kim JE (2008), Kim JE (2008)	8
TP53	0	KMT2A	58	pull down, affinity chromatography technology	Dou Y (2005), Fogeron ML (2013)	2
TP53	0	ALYREF	0	affinity chromatography technology	Horikawa I (2014)	1
DOT1L	7	MLLT6	2	two hybrid, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Reisenauer MR (2009), Reisenauer MR (2009), Reisenauer MR (2009), Reisenauer MR (2009), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
INTS14	5	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	NIN	4	affinity chromatography technology	Hein MY (2015)	1
TP53	0	HNRNPU	12	affinity chromatography technology	Fogeron ML (2013)	1
MAPK7	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yang Q (2013), Yang Q (2013)	2
KMT2A	58	HIST3H3	0	enzymatic study, unspecified method, enzymatic study, enzymatic study, enzymatic study	Cao F (2010), Avdic V (2011), Benedikt A (2011), Shinsky SA (2015), Weirich S (2017)	5
DOT1L	7	HIST1H2BB	3	affinity chromatography technology	Park G (2010)	1
KMT2A	58	HIST2H3C	0	enzymatic study	Wu L (2011)	1
DOT1L	7	EBNA1BP2	0	affinity chromatography technology	Hein MY (2015)	1
MLLT3	0	SIRT1	3	affinity chromatography technology	Park G (2010)	1
KIF24	11	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	HNRNPU	12	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Park G (2010), Havugimana PC (2012), Hein MY (2015), Hein MY (2015)	4
HNRNPU	12	H1FX	0	affinity chromatography technology	Hein MY (2015)	1
GNL3	3	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Tsai RY (2002), Tsai RY (2002), Tsai RY (2002), Meng L (2008), Meng L (2008)	5
MLLT1	1	MLLT6	2	affinity chromatography technology	Park G (2010)	1
AFF1	1	NPM1	0	affinity chromatography technology	Benedikt A (2011)	1
HIST1H1C	2	H1FX	0	biochemical	Havugimana PC (2012)	1
DOT1L	7	HIST1H2AA	1	affinity chromatography technology	Park G (2010)	1
HNRNPU	12	GNL3	3	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	YBX3	0	affinity chromatography technology	Park G (2010)	1
KMT2A	58	MLLT1	1	affinity chromatography technology, imaging technique	Yokoyama A (2010), Yokoyama A (2010)	2
DOT1L	7	IBTK	3	affinity chromatography technology	Hein MY (2015)	1
DOT1L	7	ALYREF	0	affinity chromatography technology	Park G (2010)	1
MLLT3	0	MLLT10	3	affinity chromatography technology	Monroe SC (2011)	1
MLLT3	0	MLLT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), He N (2011), Takahashi H (2011)	4
NANOG	0	DOT1L	7	genetic interference	Onder TT (2012)	1
DOT1L	7	HNRNPU	12	affinity chromatography technology	Park G (2010)	1
NANOG	0	IBTK	3	affinity chromatography technology	Oliviero G (2015)	1
DOT1L	7	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010), Hein MY (2015)	3
KMT2A	58	MLLT3	0	affinity chromatography technology, affinity chromatography technology	Monroe SC (2011), Biswas D (2011)	2
DOT1L	7	HIST1H1A	0	affinity chromatography technology	Park G (2010)	1
EBNA1BP2	0	NPM1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOT1L	7	SYNCRIP	6	affinity chromatography technology	Park G (2010)	1
HNRNPU	12	ALYREF	0	affinity chromatography technology	Hein MY (2015)	1
EBNA1BP2	0	HIST1H1A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ORC1	3	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
NANOG	0	HIST2H3C	0	affinity chromatography technology	Oliviero G (2015)	1
NPM1	0	YBX3	0	affinity chromatography technology	Park G (2010)	1
LIN28A	1	EBNA1BP2	0	affinity chromatography technology	Li S (2014)	1
AFF1	1	MLLT10	3	affinity chromatography technology	Benedikt A (2011)	1
NPM1	0	SIRT1	3	affinity chromatography technology	Park G (2010)	1