PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KEAP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Ichikawa T (2009), Lau A (2010), Li Y (2012), Niture SK (2013), Kaspar JW (2012), Kaspar JW (2012), Zhang DD (2004), Lo SC (2006)	9
CUL3	17	ACTB	8	affinity chromatography technology	Bennett EJ (2010)	1
RB1	2	ENC1	0	affinity chromatography technology, pull down, affinity chromatography technology	Kim TA (1998), Kim TA (1998), Kim TA (2005)	3
KEAP1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Niture SK (2013), Prince TL (2015), Prince TL (2015)	3
SNCA	0	ENC1	0	unspecified method	Woods WS (2007)	1
NACC1	9	ENC1	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
ENC1	0	KLHL25	6	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	SNCA	0	pull down	Falsone SF (2009)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
SNCA	0	ACTB	8	affinity chromatography technology, affinity chromatography technology	Jeannotte AM (2008), Jeannotte AM (2008)	2
ENC1	0	RBX1	2	affinity chromatography technology	Zhang DD (2005)	1
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
HNRNPL	3	NUDCD3	0	affinity chromatography technology	Fei T (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
HSP90AA1	7	NUDCD3	0	affinity chromatography technology	Gano JJ (2010)	1
CUL3	17	KLHL25	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yanagiya A (2012), Bennett EJ (2010), Huttlin EL (2017), Zhang C (2016)	4
KEAP1	0	ENC1	0	affinity chromatography technology	Wang XJ (2009)	1
NFE2L2	1	ENC1	0	affinity chromatography technology, pull down, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seng S (2007), Seng S (2007), Seng S (2009), Seng S (2009), Seng S (2009), Seng S (2010), Seng S (2010)	7
ENC1	0	ACTB	8	far western blotting, affinity chromatography technology	Liang XQ (2004), Liang XQ (2004)	2
ENC1	0	PLIN5	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	ENC1	0	affinity chromatography technology	Fei T (2017)	1
SQSTM1	0	SNCA	0	imaging technique	Schwarz L (2012)	1
ENC1	0	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	KLHL25	6	affinity chromatography technology	Taipale M (2012)	1
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CUL3	17	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
KEAP1	0	NFE2L2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cullinan SB (2003), Shibata T (2008), Wang XJ (2008), Nioi P (2007), Tanigawa S (2007), Tanigawa S (2007), Hong F (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2003), McMahon M (2006), Ichikawa T (2009), Niture SK (2009), Niture SK (2009), Wu JH (2010), Wong DP (2010), Wong DP (2010), Yu M (2011), Lau A (2010), Lau A (2010), Kay HY (2010), Sun Z (2011), Sun Z (2011), Li X (2004), Li X (2004), Lo SC (2008), Plafker KS (2010), Plafker KS (2010), Yao JW (2012), Li Y (2012), Lo SC (2006), Lo SC (2006), Lo SC (2006), Eggler AL (2005), Zipper LM (2002), Sekhar KR (2002), Seng S (2009), Hast BE (2013), Hoerer S (2013), Baba K (2013), Wang J (2011), Ichimura Y (2013), Baird L (2013), Baird L (2013), Gorrini C (2013), Schaap M (2013), Jiang ZY (2014), Hast BE (2014), Hast BE (2014), Hast BE (2014), Qin S (2014), Buommino E (2012), Kaspar JW (2012), Kaspar JW (2012), Camp ND (2012), Zhang DD (2004), Furukawa M (2005), Khan H (2015), Huo L (2015), Foygel K (2015), Liu K (2015), Lo SC (2006), Kim WD (2012), Kim WD (2012), Kim WD (2012), Zhang Y (2016), Zhang Y (2016), Wu G (2017), Villeneuve NF (2013), Ma J (2012), Ma J (2012), Ma J (2012), Ge W (2017), Ge W (2017), Yoshizaki Y (2017), Yoshizaki Y (2017), Quinti L (2017), Wang Q (2017), Ha Kim K (2017), Yang C (2016), Mulvaney KM (2016), Lu K (2017)	82
ENC1	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Lee H (2015), Lee H (2015)	2
ENC1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010), Huttlin EL (2017)	3
HSP90AA1	7	ENC1	0	affinity chromatography technology	Taipale M (2012)	1
ENC1	0	ENC1	0	pull down, enzymatic study	Kim TA (2005), Zhang DD (2005)	2
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
SQSTM1	0	NFE2L2	1	imaging technique	Lau A (2010)	1
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
NACC1	9	CUL3	17	affinity chromatography technology, affinity chromatography technology	Shen H (2007), Shen H (2007)	2