PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXO7	1	CAMK1	4	enzymatic study	Teixeira FR (2016)	1
FBXO7	1	MARK2	6	enzymatic study	Teixeira FR (2016)	1
ST6GALNAC3	1	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHF19	3	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CER1	0	CAMK1	4	affinity chromatography technology	Huttlin EL (2015)	1
CAMKK2	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CAMK1	4	BLK	4	affinity chromatography technology	Huttlin EL (2015)	1
GCM1	2	HDAC5	4	affinity chromatography technology, affinity chromatography technology	Chuang HC (2006), Chuang HC (2006)	2
CCDC106	1	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CGB2	0	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CAMK1D	4	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC4	10	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CAMK1	4	PPME1	0	enzymatic study	Lee CW (2014)	1
CAMK1D	4	APP	1	pull down	Olah J (2011)	1
CDO1	2	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
HDAC5	4	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Martin M (2008), Greco TM (2011)	2
FBXO7	1	CDK14	4	enzymatic study	Teixeira FR (2016)	1
CAMK1	4	MARK2	6	two hybrid, unspecified method, pull down, affinity chromatography technology, enzymatic study	Uboha NV (2007), Uboha NV (2007), Uboha NV (2007), Uboha NV (2007), Uboha NV (2007)	5
PNKD	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HSPB1	2	CAMK1	4	two hybrid	Katsogiannou M (2014)	1
FBXO7	1	BLK	4	enzymatic study	Teixeira FR (2016)	1
PNKD	2	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM19A3	0	PPP2CA	7	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1B	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Guidoboni M (2005), Vlach J (1996), Vlach J (1997), Tsai CH (2009), Ciarallo S (2002), Bindra RS (2002), Kossatz U (2006), Grimmler M (2007), Rolland T (2014), Hein MY (2015), Barbash O (2009), Huttlin EL (2017)	13
CAMK1	4	GCM1	2	enzymatic study	Chang CW (2011)	1
FAM153B	0	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
IL16	2	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CAMK1	4	CAMKK2	3	enzymatic study	Matsushita M (1999)	1
HDAC4	10	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Martin M (2008), Li J (2012)	2
HDAC5	4	CAMK1	4	affinity chromatography technology	Backs J (2006)	1
CAMK1	4	CDK4	2	enzymatic study	Mallampalli RK (2013)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
PIK3R3	0	CAMK1	4	two hybrid	Grossmann A (2015)	1
CDK4	2	APP	1	pull down	Olah J (2011)	1
GCM1	2	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Chuang HC (2006), Chuang HC (2006)	2
EPHA1	5	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CCDC106	1	APP	1	pull down	Olah J (2011)	1
CDKN1B	1	CDK4	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Cariou S (2000), Guidoboni M (2005), Bustany S (2011), Hsu SP (2008), Radu M (2008), Mori S (1999), Kokontis JM (1998), Orend G (1998), Vlach J (1996), Vlach J (1997), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Mandal M (1998), Larrea MD (2009), Seo DW (2006), Kossatz U (2006), Kossatz U (2006), Mallampalli RK (2013), Varjosalo M (2013), Huttlin EL (2015), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	25
PPP2CA	7	PPME1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Glatter T (2009), Huttlin EL (2015), Lee CW (2014), Lee CW (2014), Pokharel YR (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017)	10
HDAC9	7	CAMK1	4	affinity chromatography technology	Li X (2004)	1
CDK14	4	CAMK1	4	affinity chromatography technology	Varjosalo M (2013)	1
CDK4	2	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Sugimoto M (1999), Serrano M (1993), Lin J (2001), Taules M (1998), Cariou S (2000), Coleman KG (1997), Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Diehl JA (1997), Okabe H (2007), Bustany S (2011), Gladden AB (2003), Sweeney KJ (1997), Musgrove EA (1996), Vlach J (1996), Garcia-Morales P (2006), Bindra RS (2002), Ruas M (2007), Poon RY (1996), Ramachandran N (2004), Larrea MD (2009), Waaijers S (2013), Mallampalli RK (2013), Rolland T (2014), Chen TC (2014), Barbash O (2009), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Ghiani C (2001), Ito H (2016), Huttlin EL (2017), Roessig L (2001), Qie S (2017)	35
FAM19A3	0	CAMK1	4	affinity chromatography technology	Huttlin EL (2017)	1
CAMK1	4	CDKN1B	1	affinity chromatography technology, enzymatic study	Mallampalli RK (2013), Mallampalli RK (2013)	2
HDAC4	10	CAMK1	4	affinity chromatography technology	Backs J (2006)	1
PPP2CA	7	CAMK1	4	enzymatic study	Lee CW (2014)	1
CAMK1	4	APP	1	pull down	Olah J (2011)	1
CAMK1	4	CCND1	1	enzymatic study	Mallampalli RK (2013)	1
HDAC9	7	HDAC4	10	pull down	Petrie K (2003)	1