PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NANOG	0	EDF1	0	affinity chromatography technology	Oliviero G (2015)	1
MAPK6	1	DPPA4	0	two hybrid	Vinayagam A (2011)	1
HIST1H3A	3	EDF1	0	bioid	Lambert JP (2015)	1
EDF1	0	IDH3G	1	biochemical	Havugimana PC (2012)	1
MAPK6	1	EDF1	0	two hybrid	Vinayagam A (2011)	1
RNASEH2A	0	EDF1	0	biochemical	Wan C (2015)	1
JUN	0	TBP	0	pull down, pull down	Franklin CC (1995), Franklin CC (1995)	2
MOV10	6	EDF1	0	affinity chromatography technology	Castello A (2012)	1
RC3H1	6	EDF1	0	affinity chromatography technology	Murakawa Y (2015)	1
UBE2I	0	NR5A2	4	enzymatic study, enzymatic study	Yang SH (2006), Ogawa H (2009)	2
CEBPA	0	EWSR1	2	affinity chromatography technology	Bararia D (2008)	1
TRIM25	5	RXRA	1	affinity chromatography technology	Choudhury NR (2017)	1
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
MEOX2	2	EDF1	0	two hybrid	Rolland T (2014)	1
EWSR1	2	EDF1	0	bioid	Elzi DJ (2014)	1
EDF1	0	CEBPA	0	pull down	Miotto B (2006)	1
UBE2I	0	EDF1	0	enzymatic study	Jakobs A (2007)	1
JUN	0	EDF1	0	affinity chromatography technology, pull down	Miotto B (2006), Miotto B (2006)	2
IMPDH1	2	EDF1	0	biochemical	Wan C (2015)	1
TRIM25	5	HNRNPF	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CEBPA	0	JUN	0	affinity chromatography technology	Zada AA (2006)	1
EWSR1	2	DNAJB1	1	bioid	Elzi DJ (2014)	1
EDF1	0	NR1H3	1	pull down, two hybrid	Brendel C (2002), Brendel C (2002)	2
UBE2I	0	SOX4	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Pan X (2006), Pan X (2006), Pan X (2006)	3
TBP	0	RXRA	1	pull down, two hybrid	Schulman IG (1995), Schulman IG (1995)	2
EDF1	0	HNRNPF	5	biochemical	Wan C (2015)	1
PPARG	0	JUN	0	unspecified method	Lee G (2002)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
EDF1	0	DNAJB1	1	biochemical	Wan C (2015)	1
UBE2I	0	NR5A1	1	enzymatic study	Ogawa H (2009)	1
EDF1	0	NR5A2	4	pull down	Brendel C (2002)	1
UBE2I	0	PPARG	0	enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology	Ogawa H (2009), Hartig SM (2015), Hartig SM (2015)	3
RXRA	1	NR1H3	1	pull down, two hybrid	Miyata KS (1996), Albers M (2005)	2
MOV10	6	RNASEH2A	0	affinity chromatography technology	Castello A (2012)	1
SOX4	5	EDF1	0	two hybrid	Jang SM (2015)	1
UBE2I	0	TBP	0	enzymatic study	Boyer-Guittaut M (2005)	1
EDF1	0	NRL	0	pull down	Miotto B (2006)	1
DPPA4	0	EDF1	0	affinity chromatography technology	Oliviero G (2015)	1
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
UBE2I	0	NR1H3	1	enzymatic study	Lee JH (2016)	1
DHX29	2	EDF1	0	biochemical	Wan C (2015)	1
EDF1	0	NR5A1	1	affinity chromatography technology	Kabe Y (1999)	1
EDF1	0	RXRA	1	pull down	Brendel C (2002)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
EDF1	0	TBP	0	pull down, affinity chromatography technology, pull down	Brendel C (2002), Mariotti M (2000), Kabe Y (1999)	3
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
EDF1	0	PPARG	0	pull down, two hybrid	Brendel C (2002), Brendel C (2002)	2
TRIM25	5	EDF1	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RNASEH2A	0	affinity chromatography technology	Choudhury NR (2017)	1
JUN	0	NR5A1	1	pull down	Li LA (1999)	1
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1