PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
TNFSF10	2	CASP3	0	enzymatic study	Gillissen B (2013)	1
TNFSF10	2	RBM48	1	two hybrid	Stelzl U (2005)	1
CASP8	1	PPP2CA	7	affinity chromatography technology	Xu J (2015)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
TNFSF10	2	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
TNFRSF10A	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Gonzalvez F (2012), Jeong M (2017)	4
CUL3	17	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
SOCS3	0	TNFSF10	2	affinity chromatography technology	Horndasch M (2011)	1
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
TNFSF10	2	PPP2CA	7	affinity chromatography technology	Xu J (2015)	1
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
TNFRSF10B	1	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
ZDHHC17	1	TNFSF10	2	two hybrid	Butland SL (2014)	1
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
CFLAR	1	CASP3	0	affinity chromatography technology, pull down, two hybrid	Shu HB (1997), Han DK (1997), Han DK (1997)	3
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
TNFRSF10A	0	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
TNFSF10	2	ACP5	1	two hybrid	Stelzl U (2005)	1
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
TNFSF10	2	CUL3	17	affinity chromatography technology	Xu J (2015)	1
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
TNFSF10	2	TNFRSF10D	0	pull down	Degli-Esposti MA (1997)	1
CUL3	17	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
TNFSF10	2	TNFSF10	2	x-ray crystallography	Hymowitz SG (2000)	1
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
TNFRSF10A	0	TNFSF10	2	affinity chromatography technology	Pan G (1997)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6