PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	RACK1	2	affinity chromatography technology	Lin J (2015)	1
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
TRAF1	0	VAV3	4	affinity chromatography technology	Yu J (2016)	1
TRAF6	0	VAV3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu J (2016), Yu J (2016), Yu J (2016)	3
NXF1	0	SP1	0	affinity chromatography technology	Castello A (2012)	1
TNFRSF11A	2	TRAF5	1	pull down, pull down, pull down, affinity chromatography technology	Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Wong BR (1998)	4
MAP3K7	2	TRAF5	1	affinity chromatography technology	Hong S (2007)	1
TNFRSF11A	2	TRAF6	0	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mizukami J (2002), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998), Lin J (2015), Yu J (2016)	9
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
TRAF3	1	VAV3	4	affinity chromatography technology	Yu J (2016)	1
TNFRSF11A	2	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
TRAF5	1	TRAF2	1	affinity chromatography technology, pull down, pull down	Li S (2011), Li S (2011), Pullen SS (1998)	3
NXF1	0	TNFRSF11A	2	affinity chromatography technology	Castello A (2012)	1
TRAF2	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Li S (2011), He L (2004), He L (2004), Pullen SS (1998)	4
TNFRSF11A	2	TRAF2	1	pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Darnay BG (1998), Darnay BG (1998), Darnay BG (1999), Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	7
TNFRSF11A	2	MAP3K7	2	affinity chromatography technology	Mizukami J (2002)	1
TRAF5	1	TRAF3	1	affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Li S (2011), He L (2004), Chen TC (2014)	3
TRAF6	0	TRAF5	1	two hybrid, two hybrid, two hybrid, pull down	Woodsmith J (2012), Rolland T (2014), Yu H (2011), Middleton AJ (2017)	4
TNFRSF11A	2	TRAF3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Galibert L (1998), Kim HH (1999), Kim HH (1999), Wong BR (1998)	4
TRAF1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Greenfeld H (2015)	2
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
SP1	0	TNFRSF11A	2	affinity chromatography technology	Chuang JY (2012)	1
TRAF3	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang PX (2016), Wang PX (2016), Wang PX (2016)	3
MAP3K7	2	RACK1	2	affinity chromatography technology	Lin J (2015)	1
TNFRSF11A	2	TAB2	5	affinity chromatography technology	Mizukami J (2002)	1
TRAF2	1	RACK1	2	affinity chromatography technology	Lin J (2015)	1
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
TNFRSF11A	2	VAV3	4	affinity chromatography technology	Yu J (2016)	1
TNFRSF11A	2	RACK1	2	affinity chromatography technology	Lin J (2015)	1