PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	FAM208B	4	affinity chromatography technology	Fei T (2017)	1
PPP2CA	7	CCNG2	1	affinity chromatography technology, pull down	Bennin DA (2002), Bennin DA (2002)	2
CCNG2	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology	Bennin DA (2002), Huttlin EL (2017)	2
PPP2CA	7	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017)	8
CCNG2	1	FAM208B	4	two hybrid	Rolland T (2014)	1
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
HNRNPL	3	CCNG2	1	affinity chromatography technology	Fei T (2017)	1
CCNG2	1	EFHC2	0	two hybrid	Rolland T (2014)	1
CCNG2	1	PPP2R5E	4	affinity chromatography technology	Huttlin EL (2017)	1
CCNG2	1	SKP2	2	affinity chromatography technology, affinity chromatography technology	Xu G (2008), Xu G (2008)	2
PPP2CA	7	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito A (2000), Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Dozier C (2004), Letourneux C (2006), Wan C (2015), St-Denis N (2016), Shouse GP (2011), Shouse GP (2011), Yadav L (2017)	12
CCNG2	1	NME2	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNG2	1	NRIP2	3	two hybrid	Wang J (2011)	1
CCNG2	1	PPP2R5D	29	affinity chromatography technology	Huttlin EL (2017)	1
CCNG2	1	SKP1	0	affinity chromatography technology	Xu G (2008)	1
PPP2CA	7	PPP2R5B	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Shamay M (2012), Letourneux C (2006), Letourneux C (2006), St-Denis N (2016), Yadav L (2017)	8
PPP2CA	7	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	10
CCNG2	1	PPP2R5B	1	affinity chromatography technology	Bennin DA (2002)	1
PPP2R5E	4	PPP2R5C	3	biochemical	Wan C (2015)	1