PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAP1GDS1	0	RHOA	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Vikis HG (2002), Vikis HG (2002), Berg TJ (2010), Huttlin EL (2017)	4
DIRAS3	0	DCAF10	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DIRAS3	0	FEZ2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DIRAS3	0	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
DIRAS3	0	MDM2	2	affinity chromatography technology	Huttlin EL (2015)	1
TGFB1	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
KRAS	1	PTPN1	2	genetic interference	Luo J (2009)	1
PPM1D	11	DIRAS3	0	two hybrid	Arroyo R (2015)	1
CHEK2	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
KRAS	1	FEZ2	0	genetic interference	Luo J (2009)	1
KRAS	1	DIRAS3	0	genetic interference, two hybrid	Vizeacoumar FJ (2013), Arroyo R (2015)	2
DIRAS3	0	HECTD1	16	affinity chromatography technology	Huttlin EL (2015)	1
FGFR4	6	DIRAS3	0	two hybrid	Arroyo R (2015)	1
APC	5	HECTD1	16	affinity chromatography technology	Tran H (2012)	1
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
APC	5	DIRAS3	0	two hybrid	Arroyo R (2015)	1
BAG4	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
WT1	1	DIRAS3	0	two hybrid	Arroyo R (2015)	1
PALB2	3	DIRAS3	0	two hybrid	Arroyo R (2015)	1
DIRAS3	0	SLC30A1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHEK2	2	PPM1D	11	pull down, pull down, enzymatic study, affinity chromatography technology	Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006)	4
PTPN1	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
PPM1D	11	MDM2	2	affinity chromatography technology, affinity chromatography technology	Lu X (2007), Lu X (2007)	2
DIRAS3	0	MTIF2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DIRAS3	0	RNF19B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRMS1	1	DIRAS3	0	two hybrid	Arroyo R (2015)	1
DIRAS3	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2015)	1
KRAS	1	RHOA	0	two hybrid	Daakour S (2016)	1
RAP1GDS1	0	KRAS	1	two hybrid, affinity chromatography technology	Vikis HG (2002), Berg TJ (2010)	2
RHOA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Ma J (2012), Ma J (2012)	2
MDM2	2	WT1	1	two hybrid	Wang J (2011)	1