PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM21	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
EGFR	5	LRSAM1	2	affinity chromatography technology	Amit I (2004)	1
TBK1	1	TRIM9	3	affinity chromatography technology, affinity chromatography technology	Qin Y (2016), Qin Y (2016)	2
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
TRIM23	3	TRAIP	0	two hybrid	Woodsmith J (2012)	1
CARD11	4	CCND1	1	affinity chromatography technology	Wang S (2013)	1
TRADD	0	STAT1	1	affinity chromatography technology, pull down	Wang Y (2000), Wang Y (2000)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
TRIM21	0	TRIM5	4	pull down	Li X (2006)	1
MDM2	2	CCND1	1	affinity chromatography technology	Yang P (2016)	1
USP2	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
EGFR	5	HOOK2	0	affinity chromatography technology	Foerster S (2013)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
USP2	0	PEX5	2	enzymatic study	Reglinski K (2015)	1
EGFR	5	LONP1	9	affinity chromatography technology, affinity chromatography technology	Tong J (2014), Yao Z (2017)	2
NXF1	0	PEX5	2	affinity chromatography technology	Castello A (2012)	1
USP2	0	MNAT1	0	two hybrid	Hayes SD (2012)	1
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
USP2	0	PCNA	0	enzymatic study	Masuda Y (2012)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
TRIM23	3	RAD18	3	two hybrid	Woodsmith J (2012)	1
USP2	0	TRAIP	0	two hybrid	Hayes SD (2012)	1
USP2	0	IKBKG	0	enzymatic study	Zhou H (2004)	1
FASN	15	USP2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Graner E (2004), Graner E (2004), Graner E (2004), Kim J (2012), Graner E (2004), Graner E (2004)	6
USP2	0	LONP1	9	affinity chromatography technology	Sowa ME (2009)	1
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
USP2	0	MTUS2	4	two hybrid	Rolland T (2014)	1
CBLC	1	MDM4	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF11	0	IKBKG	0	two hybrid	Colland F (2004)	1
USP2	0	DTX3	4	two hybrid	Hayes SD (2012)	1
NXF1	0	USP2	0	affinity chromatography technology	Castello A (2012)	1
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
TBK1	1	APP	1	pull down	Olah J (2011)	1
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
USP2	0	CBLC	1	two hybrid	Hayes SD (2012)	1
BEND5	0	APP	1	pull down	Olah J (2011)	1
USP2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
GOLGA2	2	NDEL1	2	two hybrid	Rolland T (2014)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TRIM46	3	MDM4	0	two hybrid	Woodsmith J (2012)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
ZNF598	6	TRIM21	0	affinity chromatography technology	Garzia A (2017)	1
USP2	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM27	2	RIPK1	2	affinity chromatography technology	Zaman MM (2013)	1
KIFC3	3	USP2	0	two hybrid	Rolland T (2014)	1
MNAT1	0	TRIM21	0	two hybrid	Woodsmith J (2012)	1
KRT15	2	NEFL	1	two hybrid	Rolland T (2014)	1
PRKAA1	2	MDM4	0	enzymatic study	He G (2014)	1
USP2	0	CCND1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Shan J (2009), Shan J (2009), Shan J (2009), Shan J (2009)	4
USP2	0	CCDC85B	0	two hybrid	Rual JF (2005)	1
MOV10	6	NFKB2	3	affinity chromatography technology	Castello A (2012)	1
TRIM46	3	BRCA1	7	two hybrid	Woodsmith J (2012)	1
TRIM27	2	TBK1	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
MOV10	6	RNF144B	0	affinity chromatography technology	Castello A (2012)	1
SCNN1A	1	SCNN1G	2	affinity chromatography technology	Buck TM (2017)	1
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
ERBB2	6	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF11	0	USP2	0	affinity chromatography technology	Poulsen SL (2013)	1
USP2	0	VCAM1	2	enzymatic study	Braunstein I (2015)	1
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
HOOK1	0	HOOK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008)	4
PRKAA1	2	KRT40	0	two hybrid	Rolland T (2014)	1
LONRF1	4	TRIM9	3	two hybrid	Woodsmith J (2012)	1
NXF1	0	NFKB2	3	affinity chromatography technology	Castello A (2012)	1
USP2	0	TRIM27	2	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
TRIM63	0	TRIM54	1	two hybrid, pull down	Centner T (2001), Centner T (2001)	2
ZAP70	5	APP	1	pull down	Olah J (2011)	1
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
CBLC	1	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography	Kim M (1999), Keane MM (1999), Keane MM (1999), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012)	6
TRAIP	0	MAP3K7	2	affinity chromatography technology	Kong QZ (2016)	1
USP2	0	SCNN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oberfeld B (2011), Ruffieux-Daidie D (2008), Ruffieux-Daidie D (2008)	3
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
VCAM1	2	LMNA	2	affinity chromatography technology	Humphries JD (2009)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
TRIM63	0	USP2	0	enzymatic study	Loch CM (2012)	1
VPS52	0	TRAF6	0	two hybrid	Rolland T (2014)	1
USP21	2	DTX3	4	two hybrid	Hayes SD (2012)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
TRIM9	3	TRIM27	2	two hybrid	Woodsmith J (2012)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
APP	1	HIST2H2AC	1	pull down	Virok DP (2011)	1
IKBKG	0	TRIM23	3	affinity chromatography technology, affinity chromatography technology	Arimoto K (2010), Arimoto K (2010)	2
TBK1	1	NFKB2	3	affinity chromatography technology	Bouwmeester T (2004)	1
NXF1	0	CCND1	1	affinity chromatography technology	Castello A (2012)	1
BRCA1	7	LONRF1	4	two hybrid	Woodsmith J (2012)	1
CASP8	1	BAP1	4	two hybrid	Arroyo R (2015)	1
MDM2	2	TRIM9	3	two hybrid	Woodsmith J (2012)	1
BRCA1	7	BAP1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jensen DE (1998), Jensen DE (1998), Jensen DE (1998), Jensen DE (1998)	4
TRIM5	4	MAP3K7	2	affinity chromatography technology	Pertel T (2011)	1
MNAT1	0	BRCA1	7	affinity chromatography technology, two hybrid	Moisan A (2004), Woodsmith J (2012)	2
USP21	2	BAP1	4	enzymatic study	Loch CM (2012)	1
TRAIP	0	TBK1	1	affinity chromatography technology	Zhang M (2012)	1
KIFC3	3	CCDC136	1	two hybrid	Rolland T (2014)	1
USP2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
HOMER3	0	APP	1	pull down	Olah J (2011)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
VCAM1	2	UBC	7	affinity chromatography technology	Humphries JD (2009)	1
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
KIFC3	3	NDEL1	2	two hybrid	Rolland T (2014)	1
TRIM63	0	BAP1	4	enzymatic study	Loch CM (2012)	1
PALB2	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang F (2009), Sy SM (2009), Zhang F (2009), Zhang F (2009), Zhang F (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Johnson N (2013), Anantha RW (2013), Hill SJ (2014), Bleuyard JY (2012), Orthwein A (2015), Orthwein A (2015), Loke J (2015), Simhadri S (2014), Ma J (2012), Ma J (2012), Foo TK (2017)	22
AURKA	1	MDM2	2	affinity chromatography technology, enzymatic study	Sehdev V (2013), Sehdev V (2013)	2
USP2	0	HOOK2	0	two hybrid	Rual JF (2005)	1
TRIM21	0	RBCK1	0	two hybrid	Woodsmith J (2012)	1
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CASP8	1	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
PCNA	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang SC (2006), Wang SC (2006), Wang SC (2006)	3
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
TBK1	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bouwmeester T (2004), Bonnard M (2000), Behrends C (2010), Li S (2011), Li S (2011), Shen RR (2012), Zhang W (2010), Huttlin EL (2017), Fang R (2017), Fang R (2017)	10
USP2	0	TRIM9	3	two hybrid	Hayes SD (2012)	1
KIFC3	3	NEFL	1	two hybrid	Rolland T (2014)	1
USP2	0	CCDC136	1	two hybrid	Rolland T (2014)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
USP2	0	PLA2G2A	1	enzymatic study	Altun M (2011)	1
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP2	0	MAP3K2	1	enzymatic study	Takeda AN (2014)	1
NXF1	0	ERBB2	6	affinity chromatography technology	Castello A (2012)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
UBE2S	2	RBCK1	0	two hybrid	Markson G (2009)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
BRCA1	7	PEX5	2	two hybrid	Wang J (2011)	1
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
RNF126	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Smith CJ (2013), Smith CJ (2013), Smith CJ (2013)	3
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
MTUS2	4	NDEL1	2	two hybrid	Rolland T (2014)	1
MDM2	2	USP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007)	4
STAT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology	Ren Y (2016), Ren Y (2016)	2
USP21	2	TRIM23	3	two hybrid	Hayes SD (2012)	1
BRCA1	7	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian F (2013), Tian F (2013), Hill SJ (2014)	3
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
USP2	0	TRIM5	4	two hybrid	Hayes SD (2012)	1
NXF1	0	LNX2	2	affinity chromatography technology	Castello A (2012)	1
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
KCNQ1	5	USP2	0	affinity chromatography technology, imaging technique	Krzystanek K (2011), Krzystanek K (2011)	2
USP2	0	BEGAIN	3	two hybrid	Rual JF (2005)	1
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
MAP3K7	2	PRKAA1	2	enzymatic study, affinity chromatography technology	Scholz R (2010), Chang MY (2010)	2
USP2	0	SCNN1G	2	affinity chromatography technology, affinity chromatography technology	Oberfeld B (2011), Ruffieux-Daidie D (2008)	2
USP2	0	LONRF1	4	two hybrid	Hayes SD (2012)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
LMNA	2	FASN	15	bioid	Roux KJ (2012)	1
USP2	0	HOMER3	0	two hybrid	Rolland T (2014)	1
TRAIP	0	APP	1	pull down	Olah J (2011)	1
USP2	0	CRY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Tong X (2012), Tong X (2012), Tong X (2012)	3
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
BRCA1	7	FASN	15	affinity chromatography technology	Ertych N (2016)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
USP2	0	CCDC57	8	two hybrid	Rolland T (2014)	1
USP2	0	IL1RL2	1	enzymatic study	Saha SS (2017)	1
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
MYC	2	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GOLGA2	2	USP2	0	two hybrid	Rolland T (2014)	1
MDM4	0	APP	1	pull down	Olah J (2011)	1
MALT1	1	USP2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li Y (2013), Li Y (2013), Ginster S (2017)	3
PRKAA1	2	TRIM27	2	two hybrid	Rolland T (2014)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
TRAF6	0	KCNQ1	5	affinity chromatography technology	Bouwmeester T (2004)	1
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
TRIM9	3	TRIM8	6	two hybrid	Woodsmith J (2012)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TRIM27	2	BEGAIN	3	two hybrid	Rual JF (2005)	1
LMNA	2	TRIM39	0	two hybrid	Dittmer TA (2014)	1
SCNN1B	1	SCNN1G	2	protein complementation assay	Faria D (2012)	1
PRKAA1	2	VPS52	0	two hybrid	Rolland T (2014)	1
CRY1	0	FASN	15	affinity chromatography technology	Papp SJ (2015)	1
RNF11	0	APP	1	pull down	Olah J (2011)	1
USP21	2	AURKA	1	enzymatic study	Min M (2015)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
USP2	0	PCGF6	0	two hybrid	Hayes SD (2012)	1
LHX4	1	LONRF1	4	two hybrid	Rolland T (2014)	1
LONRF1	4	CCDC36	1	two hybrid	Rolland T (2014)	1
NFKB2	3	USP2	0	affinity chromatography technology	Bouwmeester T (2004)	1
UBE2S	2	ZNF598	6	biochemical	Havugimana PC (2012)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
TMEM173	0	TRAF2	1	affinity chromatography technology	Yao X (2016)	1
USP2	0	RAD18	3	enzymatic study	Zeman MK (2014)	1
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
SCNN1B	1	USP2	0	affinity chromatography technology	Ruffieux-Daidie D (2008)	1
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
MNAT1	0	TRIM9	3	two hybrid	Woodsmith J (2012)	1
USP21	2	LRSAM1	2	two hybrid	Hayes SD (2012)	1
USP21	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
USP2	0	TMEM173	0	affinity chromatography technology	Zhang M (2016)	1
CARD11	4	USP2	0	affinity chromatography technology, affinity chromatography technology	Li Y (2013), Li Y (2013)	2
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
USP2	0	RNF166	0	two hybrid	Hayes SD (2012)	1
USP2	0	HIST2H2AC	1	enzymatic study	Yu M (2016)	1
TRIM46	3	RNF125	0	two hybrid	Woodsmith J (2012)	1
EGFR	5	UBE2S	2	affinity chromatography technology	Tong J (2014)	1
CCNA1	3	USP2	0	affinity chromatography technology	Kim J (2012)	1
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
RBCK1	0	MAP3K7	2	affinity chromatography technology	Tian Y (2007)	1
USP21	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Xu G (2010), Xu G (2010)	2
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
USP2	0	HOOK1	0	two hybrid	Rolland T (2014)	1
USP21	2	PCGF6	0	two hybrid	Hayes SD (2012)	1
VPS52	0	USP2	0	two hybrid	Rolland T (2014)	1
LNX2	2	TRAF2	1	two hybrid	Yu H (2011)	1
USP2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
LDLR	4	USP2	0	affinity chromatography technology	Nelson JK (2016)	1
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
LMNA	2	USP2	0	two hybrid	Dittmer TA (2014)	1
TRIM5	4	IKBKG	0	affinity chromatography technology	Pertel T (2011)	1
TNFRSF1A	3	STAT1	1	affinity chromatography technology	Wang Y (2000)	1
USP2	0	TRIM74	0	two hybrid	Hayes SD (2012)	1
USP2	0	RRP15	1	affinity chromatography technology	Sowa ME (2009)	1
RAD18	3	PCGF6	0	two hybrid	Woodsmith J (2012)	1
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP21	2	TRIM5	4	two hybrid	Hayes SD (2012)	1
RNF166	0	TRIM9	3	two hybrid	Woodsmith J (2012)	1
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
IKBKG	0	MAP3K2	1	pull down	Fenner BJ (2010)	1
RNF125	0	UBC	7	pull down	Giannini AL (2008)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
USP2	0	ENPP1	4	enzymatic study	Smith N (2016)	1
USP2	0	LHX4	1	two hybrid	Rolland T (2014)	1
NXF1	0	LMNA	2	affinity chromatography technology	Castello A (2012)	1
KIFC3	3	TRIM27	2	two hybrid	Rolland T (2014)	1
TRIM35	1	TRIM5	4	pull down	Li X (2006)	1
RRP15	1	APP	1	pull down	Olah J (2011)	1
NEFL	1	USP2	0	two hybrid	Rolland T (2014)	1
CBLC	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BAP1	4	HIST2H2AC	1	enzymatic study, affinity chromatography technology, enzymatic study	Scheuermann JC (2010), Lee HS (2014), Sahtoe DD (2016)	3
MOV10	6	PALB2	3	affinity chromatography technology	Castello A (2012)	1
ZNF598	6	USP2	0	affinity chromatography technology	Morita M (2012)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
NXF1	0	RNF144B	0	affinity chromatography technology	Castello A (2012)	1
CARD11	4	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2013), Karim ZA (2015), Liu Y (2012)	3
EGFR	5	ZAP70	5	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
USP2	0	UBOX5	4	two hybrid	Hayes SD (2012)	1
EGFR	5	PRKAA1	2	affinity chromatography technology	Tong J (2014)	1
USP2	0	RNF125	0	two hybrid	Hayes SD (2012)	1
ERBB2	6	PIK3R3	0	unspecified method	Jones RB (2006)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
APP	1	TRIM46	3	pull down	Virok DP (2011)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
MYC	2	LONP1	9	affinity chromatography technology	Koch HB (2007)	1
TRIM9	3	TRIM46	3	two hybrid	Woodsmith J (2012)	1
MAP3K7	2	TRIM8	6	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), Li Q (2011), Chen L (2017), Chen L (2017), Yan FJ (2016), Yan FJ (2016)	6
KIFC3	3	APP	1	pull down	Olah J (2011)	1
MNAT1	0	MDM4	0	two hybrid	Woodsmith J (2012)	1
TRIM23	3	RNF126	2	two hybrid	Woodsmith J (2012)	1
LNX2	2	MYLIP	1	two hybrid	Yu H (2011)	1
USP21	2	TRIM8	6	two hybrid	Hayes SD (2012)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
USP2	0	CACNA2D2	5	affinity chromatography technology	Rougier JS (2014)	1
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
RNF125	0	IL1RL2	1	imaging technique, affinity chromatography technology	Saha SS (2017), Saha SS (2017)	2
ZNF598	6	FASN	15	affinity chromatography technology	Garzia A (2017)	1
PIK3R3	0	TRIM54	1	two hybrid	Rolland T (2014)	1
EGFR	5	LMNA	2	affinity chromatography technology	Liccardi G (2014)	1
TRIM21	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
USP21	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TRIM74	0	BRCA1	7	two hybrid	Woodsmith J (2012)	1
IKBKG	0	MYC	2	affinity chromatography technology	Kim BY (2010)	1
TRIM23	3	KIFC3	3	two hybrid	Rolland T (2014)	1
UBC	7	RAD18	3	affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down	Matsumoto M (2005), Fenner BJ (2009), Bish RA (2007), Rizzo AA (2014), Rizzo AA (2014), Shereda RD (2010), Shereda RD (2010), Panier S (2012), Ali AM (2012), Thach TT (2015)	10
NXF1	0	KRT40	0	two hybrid	Rolland T (2014)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
USP2	0	TRIM35	1	two hybrid	Hayes SD (2012)	1
USP2	0	MYC	2	enzymatic study	Gonzalez-Prieto R (2015)	1
TRIM27	2	NDEL1	2	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
MYC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	RNF125	0	affinity chromatography technology	Yao Z (2017)	1
USP2	0	TRIM23	3	two hybrid	Hayes SD (2012)	1
PRKAA1	2	USP2	0	affinity chromatography technology	Al-Hakim AK (2005)	1
USP2	0	LRSAM1	2	two hybrid	Hayes SD (2012)	1
USP21	2	TRIM9	3	two hybrid	Hayes SD (2012)	1
BEGAIN	3	APP	1	pull down	Olah J (2011)	1
KIFC3	3	TRAF2	1	two hybrid	Rolland T (2014)	1
UBE2S	2	APP	1	pull down	Olah J (2011)	1
PCNA	0	TRAIP	0	affinity chromatography technology, pull down, x-ray crystallography	Hoffmann S (2016), Hoffmann S (2016), Hoffmann S (2016)	3
RAD18	3	PCNA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Song IY (2010), Inagaki A (2011), Kobayashi J (2010), Masuda Y (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Notenboom V (2007), Notenboom V (2007), Wong RP (2011), Masuda Y (2012), Unk I (2006), Tomida J (2008), Durando M (2013), Han J (2014), Han J (2014), Han J (2014), Masuda Y (2012), Masuda Y (2015), Guan J (2017)	20
TRIM54	1	USP21	2	enzymatic study	Loch CM (2012)	1
RNF11	0	STAT1	1	affinity chromatography technology	Shembade N (2009)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
TRAIP	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
RNF144B	0	UBC	7	enzymatic study	Michel MA (2017)	1
AURKA	1	USP2	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Shi Y (2011), Shi Y (2011), Shi Y (2011), Shi Y (2011), Shi Y (2011)	5
USP2	0	NDEL1	2	two hybrid	Rolland T (2014)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
NEFL	1	APP	1	imaging technique	Chen TC (2014)	1
USP2	0	LNX2	2	two hybrid	Hayes SD (2012)	1
USP2	0	MYLIP	1	affinity chromatography technology	Nelson JK (2016)	1
ERBB2	6	STAT1	1	unspecified method, imaging technique	Jones RB (2006), Chen TC (2014)	2
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
AURKA	1	ZNF598	6	genetic interference	Horlbeck MA (2018)	1
MDM4	0	USP2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Allende-Vega N (2010), Allende-Vega N (2010), Wang CL (2014), Wang CL (2014), Wang CL (2014)	5
AURKA	1	IKBKG	0	affinity chromatography technology	Irelan JT (2007)	1
LNX2	2	PIK3R3	0	two hybrid	Yu H (2011)	1
TRIM34	1	TRIM5	4	two hybrid, two hybrid	Zhang F (2006), Woodsmith J (2012)	2
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
CBLC	1	ZAP70	5	unspecified method	Takeshita K (2012)	1
MAP3K7	2	USP2	0	affinity chromatography technology	Li Y (2013)	1
MYLIP	1	LDLR	4	enzymatic study, affinity chromatography technology, enzymatic study, unspecified method, affinity chromatography technology, imaging technique	Sorrentino V (2011), Sorrentino V (2011), Zhang L (2011), Calkin AC (2011), Nelson JK (2016), Scotti E (2013)	6
TRIM54	1	USP2	0	enzymatic study	Loch CM (2012)	1
TBK1	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsuchida T (2010), Li S (2011), Zhang J (2012), Zhang J (2012), Chen X (2014), Ni G (2017), Zhang Q (2017)	7
USP2	0	TRIM21	0	two hybrid	Hayes SD (2012)	1
VCAM1	2	FASN	15	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	KCNQ1	5	affinity chromatography technology	Yao Z (2017)	1
LMNA	2	PCNA	0	two hybrid	Dittmer TA (2014)	1
EGFR	5	TRIM23	3	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
TRIM23	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017)	4
MNAT1	0	TRIM34	1	two hybrid	Woodsmith J (2012)	1
KRT15	2	USP2	0	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
CCND1	1	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology	Matsuoka S (1994), Xiong Y (1993), Zhang H (1993)	3
MDM2	2	RNF126	2	two hybrid	Woodsmith J (2012)	1
PCGF6	0	PNMA1	0	two hybrid	Yu H (2011)	1
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
TRIM39	0	APP	1	pull down	Olah J (2011)	1
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
GOLGA2	2	PRKAA1	2	two hybrid	Rolland T (2014)	1
TRIM63	0	USP21	2	enzymatic study	Loch CM (2012)	1
USP2	0	BAP1	4	enzymatic study	Mashtalir N (2014)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
MOV10	6	PEX5	2	affinity chromatography technology	Castello A (2012)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
LRSAM1	2	TRIM74	0	two hybrid	Woodsmith J (2012)	1
USP2	0	TRIM34	1	two hybrid	Hayes SD (2012)	1
AURKA	1	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Ouchi M (2004), Ouchi M (2004), Maxwell CA (2011), Maxwell CA (2011), Ouchi M (2004), Ouchi M (2004), Ertych N (2016)	7
MOV10	6	LMNA	2	affinity chromatography technology	Castello A (2012)	1
TRIM46	3	CBLC	1	two hybrid	Woodsmith J (2012)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
USP2	0	TRIM46	3	two hybrid	Hayes SD (2012)	1
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
TRAIP	0	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Lee SY (1997), Lee SY (1997), Besse A (2007), Park ES (2015)	4
PIK3R3	0	USP2	0	two hybrid	Grossmann A (2015)	1
USP2	0	ERBB2	6	enzymatic study	Liu H (2009)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
LONRF1	4	GOLGA2	2	affinity chromatography technology	Huttlin EL (2017)	1
LRSAM1	2	MDM4	0	two hybrid	Woodsmith J (2012)	1
MNAT1	0	TRIM5	4	two hybrid	Woodsmith J (2012)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
CRY1	0	TRAF2	1	two hybrid	Rual JF (2005)	1
BRCA1	7	HIST2H2AC	1	enzymatic study, enzymatic study	Chen A (2002), Thakar A (2010)	2
MNAT1	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
USP21	2	CBLC	1	two hybrid	Hayes SD (2012)	1
TNFRSF1A	3	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahmad R (2007), Fan YH (2011), Cusson-Hermance N (2005), Blonska M (2005), Mitsuhashi S (2008)	5
USP2	0	RNF144B	0	two hybrid	Hayes SD (2012)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
USP2	0	BEND5	0	two hybrid	Rual JF (2005)	1
USP2	0	LZTS2	4	two hybrid	Rolland T (2014)	1
MALT1	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Oeckinghaus A (2007), Karim ZA (2015)	2
KIFC3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
CBLC	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BRCA1	7	CCND1	1	pull down, enzymatic study	Wang H (1997), Kehn K (2007)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
PCNA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Groehler AL (2010), Banks D (2006)	2
USP2	0	PALB2	3	enzymatic study	Orthwein A (2015)	1
USP2	0	ZAP70	5	enzymatic study	Naik E (2016)	1
NDEL1	2	KRT40	0	two hybrid	Rolland T (2014)	1
NDEL1	2	APP	1	pull down	Olah J (2011)	1
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
PRKAA1	2	MTUS2	4	two hybrid	Rolland T (2014)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
EGFR	5	TBK1	1	affinity chromatography technology	Tong J (2014)	1
RAD18	3	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TBK1	1	RNF11	0	affinity chromatography technology, affinity chromatography technology	Charoenthongtrakul S (2013), Charoenthongtrakul S (2013)	2
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
USP21	2	KRT40	0	two hybrid	Rolland T (2014)	1
EGFR	5	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Olayioye MA (1999), Xia L (2002), Andl CD (2004), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	8
MOV10	6	USP2	0	affinity chromatography technology	Castello A (2012)	1
KIFC3	3	KRT40	0	two hybrid	Rolland T (2014)	1
USP2	0	CCDC36	1	two hybrid	Rolland T (2014)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
NFKB2	3	IKBKG	0	affinity chromatography technology	Bouwmeester T (2004)	1
BRCA1	7	STAT1	1	affinity chromatography technology, pull down, two hybrid	Ouchi T (2000), Ouchi T (2000), Ouchi T (2000)	3
USP2	0	PNMA1	0	two hybrid	Rolland T (2014)	1
USP2	0	TBK1	1	affinity chromatography technology	Zhang L (2014)	1